Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"photoreceptor degeneration"”.
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Apoptosis in retinal photoreceptor degeneration.
Apoptosis in retinal photoreceptor degeneration.
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Role of oxidative stress in photoreceptor degeneration
… retinal dystrophies associated with progressive degeneration of photoreceptor cells. Mutations in numerous genes have been implicated in RP, which have distinct pathophysiological mechanisms and lead to retinal degeneration at different rates. The aim of this thesis was to investigate the role of …
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rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration
The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) …
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Inflammasome upregulation and activation in photoreceptors of type 2 diabetes and N-methyl-N-nitrosourea models is attenuated by Wedelolactone
… (DR) and some aspects of retinal neurodegeneration although the precise underlying mechanisms linking these pathologies are not fully understood. Inflammation and oxidative damage are linked pathogenic processes that are enhanced during obesity and type 2 diabetes mellitus (T2DM). …
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The role of Interleukin-33 in retinal degenerative diseases
… cell function with emphasis on retinal neuronal degeneration and inflammation, using murine models of experimentally induced retinal detachment (RD) and chemical-induced diabetes.<br/><br/>Firstly, immunohistochemistry showed that IL-33 was localised to the nuclei of Müller cells in normal …
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The Neurogenic Capacity of Müller Glia and Synaptic Remodeling in the Mammalian Retina: Implications for Regenerative Therapies
… mouse model of retinitis pigmentosa. Following photoreceptor degeneration, second order neurons (horizontal, and bipolar cells) showed dendrite retraction, cellular migration, and a loss of post-synaptic elements that increased with disease progression. Surprisingly, the inner retina remained …
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Influence of retinal states on the development and maintenance of retinofugal projections
… of mice with retinal remodeling after photoreceptor degeneration (PD). ΔCT mice, with mild remodeling, and TG9N mice, with aggressive remodeling, retain gross anatomical and physiological connectivity in the presence of attenuated visual activity compounded by organic remodeling. …
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Einfluss funktionsloser Photorezeptoren auf die Anatomie der Retina - Eine licht- und elektronenmikroskopische Studie anhand der CNGA3-/-Rho-/- Maus
… diese Erkrankung, die durch eine fortschreitende Degeneration von Photorezeptoren verursacht wird, zur vollständigen Erblindung. Bisher beschrieb man den pathologischen Prozess vor allem an rd-Mäusen. Allerdings setzt bei diesen die Degeneration sehr früh ein. Somit ist die Übertragbarkeit auf den …
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Understanding The Visual And Auditory Defect In Ush2a Mouse Model
… USH patients. Usherin has been detected in the photoreceptors of the retina and in the developing inner ear cell stereocilia. The USH2A gene is very large and attempting gene therapy with conventional viral delivery is not easily attainable due to limited payload capacity of commonly used …
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Analyse verschiedener Netzhautkulturmodelle an der Netzhaut vom adulten Hausschwein
… of in vivo retina, except for an early degeneration of photoreceptor outer segments and a minor reduction of ganglion cell bodies. Astrocytes in control retina could be visualized reproducibly by both GFAP antibodies in immunohistology, whereas variable expression patterns of GFAP and …