Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"photodynamic therapy (PDT)"”.
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EGFR-Targeted Polymeric Micelles For Targeted Pc 4-PDT Of Oropharyngeal Tumors
Photodynamic Therapy (PDT) holds great promise for the treatment of head and neck (H&N) carcinomas where repeated loco-regional therapy often becomes necessary due to the highly aggressive and recurrent nature of the cancers. Conventional surgery, chemotherapy and radiotherapy approaches cause …
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Synthesis of Phenothiazinium Derivatives
<p>Photodynamic Therapy (PDT) of cancer involves radiating photosensitizing drugs with light in tumors, which results in generating active singlet oxygen that kills cancer cells. Photosensitizers currently used in PDT are of low quantum yield and require high energy radiation, normally laser. …
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LS301 Fluorescence-guided Photodynamic Therapy of brain cancer using PpIX photosensitizer
… and as well as acts as a photosensitizer for photodynamic therapy (PDT). However, the accurate tumor delineation using PpIX is limited by autofluorescence and superficial penetration depth. LS301 is a tumor-targeted near-infrared (NIR) contrast agent developed in our lab which allows deeper …
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Molecular Design and Photophysical Characterization of Synthetic Bacteriochlorins for Solar Energy Conversion and Photodynamic Therapy
… of bacteriochlorins as photosensitizers for photodynamic therapy: PDT). The factors studied and correlated include photostability, redox potentials, photophysical properties, electrochemical and molecular-orbital characteristics, reactive-oxygen-species production, photosensitizer cellular …
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METAL NANOSTRUCTURES-ENHANCED AIE-BASED PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY
Photodynamic therapy (PDT) is a non-invasive technique, based on photosensitizer molecules, that has been extensively used for therapy of different non-oncological diseases and various cancers. However, traditional photosensitizers are suffering from aggregation-caused quenching (ACQ) effect, due …
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EXPLORING HETEROSTRUCTURED UPCONVERSION NANOPARTICLES: FROM RATIONAL PARTICLE ENGINEERING TO BIOMEDICAL APPLICATIONS
Upconversion nanoparticle (UCNP)-based photodynamic therapy (PDT) with unique anti-stokes luminescence features are of great interest. UCNP-based PDT affords greater tissue penetration depths than that of visible lights and serves as suitable nanoplatforms carrying photosensitizers as well. …
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Effects of combination therapies on age-related macular degeneration
… endothelial growth factor (VEGF) drugs, photodynamic therapy (PDT) and steroids. All three require invasive eye procedures that carry their own risks. The possibility of more effective treatments by combining these therapies is being tested through clinical trials. Studies of combined PDT …
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Treatment of oral fungal infections using antimicrobial photodynamic therapy: A systematic review and meta-analysis
… This section contains the definitions used for “photodynamic therapy”, “conventional antifungal medication” and “oral fungal infections”. It also provides details of quantitative and qualitative methods used to analyse the effectiveness of photodynamic therapy (PDT) and conventional antifungal …
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A Multifunctional Solution Composed Of TMPyP, 1,5-DHN, And Fe(III) Ions That Produces Reactive Oxygen Species (ROS) In Aerobic, Anaerobic, And H2O2 Environments
<p>Photodynamic therapy (PDT) has become a widely popular therapeutic approach for treating various types of cancer over the past several decades. PDT utilizes a photosensitizer, visible light, and oxygen, to produce reactive oxygen species (ROS) which can be used to treat cancer and inhibit growth …
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Synthesis and electrochemistry of photoantimicrobial agents based on the azine chromophore
Photodynamic Therapy (PDT) is a ôancer treatment involving selective retention of a photoactive drug in tumour cells and tissue. Subsequent illumination with light of the correct wavelength can result in tumour destruction, generally assumed to be mediated by singlet oxygen ( 102) generated by the …
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Investigating the by-stander effect of Hypericin induced photodynamic therapy on human skin cells
… incidence rate in South Africa is increasing. Photodynamic therapy (PDT) has been shown to be an effective treatment modality, through topical administration, for treatment of non-melanoma skin cancers. Our group investigates hypericin-induced PDT (HYP-PDT) for the treatment of both …
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A feasibility evaluation of x-ray fluorescence emission tomography and x-ray luminescence tomography for real-time assessment of photodynamic therapy
Photodynamic Therapy (PDT) has found use in a wide-array of clinical applications such as in cancer and acne treatment. Photodynamic therapy, uses a photosensitive compound activated by a specific wavelength photon to produce cytotoxic oxygen species (either in free radical form or in singlet …
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Avaliação do uso de nano carreadores de ramnolipídeos associados ao fotossensibilizador azul de Taylor na terapia fotodinâmica antimicrobiana contra Staphylococcus aureus: estudo in vitro
… for alternative therapies, such as Antimicrobial Photodynamic Therapy (PDT). With the advancement of science, nanotechnology techniques are increasingly present, promoting the enhancement of existing techniques. This study evaluated, in vitro, the efficacy of PDT coupled with carrier …
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From the Making to the Tuning to the Use of Chlorins for Biomedical Applications
… dyes that display drug-like attributes such as photodynamic therapy (PDT) agents. More recently, it was demonstrated that chlorins can serve both as a PDT agent and as a modality for fluorescence or PET imaging. Thus, multifunctional chlorins eliminate the differences that may occur in …
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Photorejuvenation Induced by 5-Aminolevulinic Acid Photodynamic Therapy in the Patients with Actinic Keratosis: A Histological Analysis
… of abnormal elastotic material in the dermis. Photodynamic therapy (PDT) is one of many treatment options available for photoaging; it has been shown to be effective, whereas the data on most other studies is based on clinical observation. Objectives: I investigated whether 5-aminolevulinic …
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Method For Determination Of Singlet Oxygen Quantum Yields For New Fluorene-based Photosensitizers In Aqueous Media For The Advancement Of Photodynamic Therapy
Photodynamic therapy (PDT) has been investigated over the past three decades and is currently an approved therapeutic modality for skin cancer, the treatment of superficial bladder, early lung and advanced esophageal cancers, and age-related macular degeneration in a number of countries. In PDT, …
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Photodynamic Therapy utilizing Interstitial Light Delivery Combined with Spectroscopic Methods
… development of modalities for both diagnosis and therapy. Most of the currently available methods suffer from serious disadvantages. The treatments, e.g. ionising radiation, chemotherapy, surgery, may themselves induce malignancies or the patient may be physically impaired for a longer period of …
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Synthesis and functionalizations of tetrapyrrole derivatives
… to have attractive potential applications in photodynamic therapy of tumors. The second part of Chapter 5 concerns the improved syntheses of 2,2'-bipyrrole, which is an important part of our effort to improve the synthesis of porphycene and related tetrapyrrole derivatives. The potential …
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Nanoscale Enhancement of Photosensitized Radionuclide Stimulated Therapy
<p>Photodynamic therapy (PDT) provides efficient tumor killing through the generation of reactive oxygen species (ROS) from the optical excitation of a photosensitizer (PS). Furthermore, this mechanism is highly immune stimulating, providing systemic tumor immunity with a reduction in metastasis. …
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Trigger-responsive nanomedicines through controlled chemistry
… further developed and was co-encapsulated with photodynamic sensitizer, chlorin e6, in one NP for combination therapy to combat tumor resistance to photodynamic therapy (PDT) caused by a hypoxic environment. The ultra-high drug loading nanoparticles with controllable release and defined …
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