Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 126 for “"photodynamic therapy"”.
-
New photosensitisers for photodynamic therapy
The Photodynamic Therapy (PDT) of cancer is a relatively new area of cancer research. It involves the use of tumour specific drugs that are non-toxic in the absence of light but, when irradiated, react either with oxygen to give the cytotoxic singlet oxygen or directly with biomolecules and so …
-
Polyacrylamide nanoparticle delivery systems in photodynamic therapy
… which may prove to be particularly attractive is Photodynamic Therapy (PDT). Reactive oxygen species (ROS) which cause damage to tumour tissue are not generated until the drug is activated by light, minimising generalised toxicity and giving a high degree of spatial control over the clinical …
-
A Role For Reactive Oxygen Species In Photodynamic Therapy
<p>Photodynamic therapy (PDT) is based on the ability of certain photosensitizing agents to selectively localize in neoplastic cells and their vasculature. Subsequent irradiation at a wavelength corresponding to a photosensitizer absorbance band excites the photosensitizer molecules, leading to …
-
METAL NANOSTRUCTURES-ENHANCED AIE-BASED PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY
Photodynamic therapy (PDT) is a non-invasive technique, based on photosensitizer molecules, that has been extensively used for therapy of different non-oncological diseases and various cancers. However, traditional photosensitizers are suffering from aggregation-caused quenching (ACQ) effect, due …
-
Development of porphyrin-antiangiogenic antibody immunoconjugates for photodynamic therapy
Photodynamic therapy is a novel cancer treatment, involving the combination of light, photosensitiser and molecular oxygen to produce cytotoxic species. Currently, commercially available photosensitisers, including Photofrin and Foscan, only exhibit a passive selectively towards cancerous tissue. …
-
Targeted nanoparticle platforms for selective photodynamic therapy of cancer
… demonstrated the substantial improvement in the photodynamic therapy (PDT) of cancer using multifunctional nanoparticles. The tumour-selectivity of nanoparticles carrying PDT agents can be achieved through conjugation to cancer-specific biomolecules that provide the particles with an improved …
-
Photodynamic Therapy utilizing Interstitial Light Delivery Combined with Spectroscopic Methods
… development of modalities for both diagnosis and therapy. Most of the currently available methods suffer from serious disadvantages. The treatments, e.g. ionising radiation, chemotherapy, surgery, may themselves induce malignancies or the patient may be physically impaired for a longer period of …
-
Photodynamic therapy against multidrug-resistant oral strains of Candida spp
… safe for systemic health. Within this framework, photodynamic therapy (PDT) may be a viable option for treating yeast infections. In this context, the purpose of this work is to evaluate and compare, through a clinical-laboratory multidisciplinary approach, commercially available protocols and new …
-
Investigation on the Molecular Mechanism of Photorejuvenation in Photodynamic Therapy
… due to the effects of long-term UV exposure. Photodynamic therapy (PDT) is a therapeutic modality for cutaneous malignant and premalignant condition. Recently, several clinical studies reported that the PDT has photorejuvenation effects on the aged skin. In the previous report, which is …
-
LS301 Fluorescence-guided Photodynamic Therapy of brain cancer using PpIX photosensitizer
… and as well as acts as a photosensitizer for photodynamic therapy (PDT). However, the accurate tumor delineation using PpIX is limited by autofluorescence and superficial penetration depth. LS301 is a tumor-targeted near-infrared (NIR) contrast agent developed in our lab which allows deeper …
-
Photophysics of Organic Probes and their Applications in Bioimaging & Photodynamic Therapy
… oxygen generation quantum yield. In vitro photodynamic studies demonstrated that photosensitization of the agent can induce cellular damage, subsequently leading to cell death by a necrotic cell death mechanism, supporting the therapeutic potential of using the agent for photodynamic …
-
Synthesis of Phthalocyanines and Porphyrazines for Photodynamic Therapy and Bioalytical Purposes
A series of novel symmetric and asymmetric phthalocyanines (Pcs) and porphyrazines (Pzs) bearing solubilizing groups and peripheral functionalities such as nitro, amine, acid, aminooxy, and azide, some of which can be used for conjugation or labeling reactions were synthesized in good yields. …
-
Discovering the Potential of Photoluminescent Ruthenium(II) Complexes as Photodynamic Therapy Agents
… ruthenium complexes that demonstrate promise as photodynamic therapy (PDT) agents. [(AnthbpyMe)(bpy)Ru(dpp)]2+ (1) and [(AnthbpyMe)2Ru(dpp)]2+ (2) absorb visible light with metal-to-ligand charge transfer (MLCT) transitions at 459 nm (16,000 M-1 cm-1 ) and 461 nm (21,000 M-1 cm-1 ), respectively. …
-
Antimicrobial Photodynamic Therapy in Clinical Dentistry: Unravelling the Mechanisms and Exploring Hidden Benefits
Antibiotic efficacy, as a mainstay of therapy support in addressing bacterial infection, has witnessed a decrease due to the extensive and inappropriate use of these drugs; consequent efforts to find new methods to eradicate bacteria and combat multidrug resistance are intensifying. Antimicrobial …
-
Investigation of different light delivery schemes in photodynamic therapy of human glioma spheroids
… of human glioma spheroids to ALA-mediated photodynamic therapy subjected to various optical dose delivery schemes is investigated. In particular, the effects of fluence, fluence rate, light dose fractionation and long-term repeat PDT is considered. Improved PDT response was found for low …
-
NANOCOMPOSITES CONTAINING GOLD NANORODS FOR TWO-PHOTON IMAGING, PHOTODYNAMIC THERAPY AND DRUG DELIVERY
… this nanocomposite in two-photon imaging, photodynamic therapy and drug delivery for simultaneous diagnosis and therapy in vitro.
Page 1 of 7