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Showing 1 to 5 of 5 for “"photocaging"”.
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Towards Photoredox-Cleavable Prodrugs
… release approach employing a chromophore as the photocaging group, which absorbs light and followingly undergoes cleavage. While this approach operationally simple, it requires complex photocaging groups, which have the inherent drawback of being unstable towards light. Photouncaging can also be …
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Synthesis And Biological Evaluation Of Nitrile-Based Inhibitors Of Cysteine Proteases Caged With Ruthenium Complexes
… the applicability of ruthenium complexes in photocaging cathepsin inhibitors for gaining spatiotemporal control over enzyme inhibition. Later we reported that ruthenium (II) tri(2-pyridylmethyl)amine, a polypyridyl ligand distinct from the established Ru(bpy)2 class, is an effective caging …
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Semi-Synthesis of the Transcription Factor SMAD2 Containing Caging Groups and Phosphoaminoacid Analogues
… of the appropriate wavelength to remove the photocaging group. This approach can be employed to generate caged analogues of any phosphorylated protein. A parallel caging approach was developed that relies upon indirect blockade of Smad2 phospho-dependent activity through the installation of a …
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SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOACTIVE MOLECULES LINKED TO PHOTOREMOVABLE PROTECTING GROUPS FOR SPATIO-TEMPORAL CONTROL OF THEIR ACTIVITY THROUGH PHOTOACTIVATION
… also pursued. The first project involved the photocaging of ivabradine in order to achieve selective antagonism of different subtypes of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Ivabradine is a clinically used bradycardic agent indicated for the treatment of stable …
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Engineering a Photo-Control Mechanism for RNA Interference
… targeting. One potential targeting strategy uses photocaging techniques, which involves the covalent attachment of photolabile compounds to the effector NA species that blocks bioactivity until exposed to near UV-light. This work demonstrates that fully-2’-fluorinated nucleic acids (FNAs) can …