Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"photoactivated"”.
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Second Generation Photoactivated Insulins
The photoactivated depot (PAD) is a minimally invasive approach developed for a continuously variable light stimulated release of insulin. In this approach, a protein depot that can last for days is injected under the skin. A light source placed on the skin above the site of injection can trigger …
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Photoactivated Fixation of Cartilage Tissue
Cartilage repair and/or replacement is necessary for many orthopaedic conditions including fissures from blunt trauma, autograft or allograft transplantation, and replacement of focal defects with biological or synthetic constructs. In cartilage repair, initial integration between the host tissue …
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Statistical image analysis of photoactivated localization microscopy
… lateral resolution and 30-50 axial resolution. Photoactivated localization microscopy is one super resolution technique that is based on photoswitchable fluorescent proteins and 2D guassian fitting. By randomly photoactivating a small percentage of molecules back to fluorescent state, the …
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Synthesis and characterization of metallic nanoparticles with photoactivated surface chemistries
During recent decades metallic nanoparticles have been found very interesting due to their unique characteristics which make them suitable for different applications. In this research, for the very first time, we tried to perform selective surface photo activation chemistry on the targeted facets …
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Structural Features of Bacteriophytochromes. Photoactivated Proteins studied by Serial Femtosecond Crystallography
The key to life on earth is sunlight, which reaches the planet as an energy source. Nature has evolved different types of photoreceptor proteins to detect optimal light conditions for biochemical processes. A type of red light detecting photoreceptor proteins are called phytochromes and are present …
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The dynamics and regulation of actin filaments in vascular endothelial cells and in a reconstituted purified protein system
… photoactivation. By increasing the width of the photoactivated band, actin filament turnover (t ~ 8 hours) can be distinguished from actin filament diffusion. Proteins believed to stabilize actin filaments against depolymerization markedly slow actin filament turnover in wide photoactivated bands …
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Broadening the scope of reactivity for neutral organic electron donors
… was investigated for their reactivity with the photoactivated donor A*. The results of these experiments were the high-yielding carbon nitrogen bond scissions, the details of which are reported herein including a mechanistic discussion and supporting evidence. Likewise, aryl methyl sulfides F …
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Analysis of sequence-selective guanine oxidation by biological agents
… oxidation induced within the same guanines by photoactivated riboflavin, a one-electron reagent. We found that, in agreement with previous studies, photoactivated riboflavin was selective for guanines of lowest IPs located within 5'-GG-3' sequences. In contrast, ONOOCO2" preferentially reacted …
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Fabrication of microfluidic devices for artificial respiration
… will be achieved by the interaction between the photoactivated metal oxide film and blood in the setting of a molded microfluidic conduit, providing a stable and implantable oxygenation platform. As a basic, scalable building block, we developed a noble "network" design which was structurally …
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Engineering artificial cell membranes by Ting F. Zhu.
… locally releasing the encapsulated contents. The photoactivated release of substances from exploding vesicles in a highly spatio-temporally controlled manner suggests potential applications of this phenomenon in many areas across disciplines.
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Investigating antimicrobial resistance mechanisms in Neisseria gonorrhoeae using peptide probes
… binding site in MtrR was elucidated via a photoactivated peptide binding study. Electrophoresis mobility shift assays indicated that the peptides do not induce derepression of the genes controlled by MtrR, although the peptide derivatives of LL-37 were shown to be substrates for the MtrCDE …
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2D and 3D patterning of molecules and cells
… to build CAD designed porous 3D hydrogels out of photoactivated poly (ethylene glycol). Hydrogels are built on glass slides that have been microcontact printed with lines of acrylic-fibronectin: during polymerization, fibronectin patterns cross-link to the surface of hydrogels forming cell …
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Novel applications of a 4-DMAP-derived organic electron donor under photoactivation
… under thermal activation of 1. In contrast, photoactivated donor 1 has now provided the reduction of 2 and 3 in good yields, while activated sulfonamides e.g. 4 were reduced in excellent yields with lower loadings of 1 at room temperature compared with the thermal activation. Chapter Three …
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Exploring new reactions with Organic Electron Donors and the complexities of the Birch reduction
… mild conditions have recently been achieved with photoactivated super-electron donor (SED). These include (but are not limited to) C-O bonds of benzylic ethers and esters, C-N bonds of benzylic sulfonamides and aromatic amides. This work has successfully widened the substrate scope of reduction by …
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Optimized Microbial Recombinant Production of HIV-1 Anti-Envelope Antibody Fragments with Applications to Single Particle Tracking of Virus Assembly
… total internal reflection microscopy (TIRF) and Photoactivated Localization Microscopy (PALM) to depict sites of molecular assembly via Env and Gag colocalization as well as measure and track other means of Env such as diffusion rates and host cell restriction factor interactions.</p> <p>Overall, …
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EXTRATO E ÓLEO DE CAFÉ VERDE: FITOQUÍMICA, DESENVOLVIMENTO DE SISTEMAS NANOESTRUTURADOS E AVALIAÇÃO IN VITRO DO POTENCIAL ANTIMICROBIANO ASSOCIADO À TERAPIA FOTODINÂMICA
… of green coffee extract of 250 µg.ml−1 and when photoactivated, acting at 125 µg.ml−1, in addition to also showing activity without the incorporated extract. This study reveals a product that structures the use of plant-derived substances in the pharmaceutical industry, stimulating the bioeconomy …
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Computational Insights Into The Oxygen Evolving Complex Of Photosystem ΙΙ
… is a unique Mn4O5Ca2+ cluster that catalyzes the photoactivated water splitting reaction. The OEC is a model system for bio-inspired artificial systems to use solar energy to pull electrons from water to produce fuel. The OEC goes through a cycle of 5 S states storing 4 holes, via electron …
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Photodynamically Activated Multifunctional Chitosan Nanoparticles to Disinfect and Improve Structural Stability of Dentin
… i.e., to generate singlet oxygen when photoactivated; and the nano-form further potentiate these specific properties. These photodynamically activable chitosan nanoparticles showed the distinct characteristics of chitosan and rose bengal. The synergistic effect of the chitosan …
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Chemical strategies for improving anti-diabetic glucagon therapy
… the construction and the design principles of a photoactivated trimeric glucagon are discussed in Chapter 2. This material is a pro-glucagon engineered to have two properties: a) low solubility such that it can be injected under the skin as an inert depot, and b) the ability to regenerate native …
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Fabrication of DNA microarrays on Poly (methylmethacrylate) substrates for biomolecular reporting
… microchannels that are reversibly sealed to the photoactivated PMMA substrates. Parallel sample processing minimizes contamination effects that can give rise to false positives which can be a significant issue especially for diagnostic applications. We demonstrate use of these protocols with …
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