Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"photoacoustic probes"”.
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Development of chemical tools for studying biology with light: Photoactivatable donors and photoacoustic probes
… towards activatable contrast agents for photoacoustic imaging, an emerging deep-tissue imaging modality. To address a lack of modular activatable probes for this imaging technique, we combined the analyte specificity of DNA aptamers with commercially available fluorophores to show the …
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Chemical probes for studying cyclooxygenase-2 and nitric oxide in living systems
… of binding-based and activity-based sensing probes to contextualize the following chapters. Chapter 2 discusses the design and validation of a fluorescent probe for detecting cyclooxygenase-2 activity with live cells, as well as the discovery of oxygen-dependent regulation that is not …
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Development of small molecule probes for fluorescence and photoacoustic molecular imaging
… use of reaction-based small-molecule fluorescent probes, a class of probes that exhibit differential fluorescence signals upon reacting with their intended target, has further rendered fluorescence imaging with good selectivity and higher sensitivity. Such reaction-based small-molecule fluorescent …
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Activatable photoacoustic contrast agents for sensing and delivering nitric oxide, and development of small molecule photoacoustic platforms with improved properties for in vivo imaging
… in cell culture; other methods, including photoacoustic imaging (PAI), ultrasound (US), magnetic resonance imaging (MRI), and positron emission tomography (PET), each provide unique capabilities and can be used effectively at diverse length scales. In the Chan group, we are particularly …
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Development of small-molecule probes for photoacoustic imaging of hypoxia
… discuss our approach for hypoxia detection using photoacoustic (PA) imaging. This method combines the resolution of optical imaging with the tissue penetration of ultrasound to enable high-resolution image acquisition at clinically relevant depths. While PA imaging can detect endogenous absorbers, …