Global ETD Search
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Showing 1 to 20 of 54 for “"photoacoustic imaging"”.
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Dual-modality thermoacoustic and photoacoustic imaging
… The combined contrasts from thermoacoustic and photoacoustic tomography: TAT and PAT) can potentially predict early stage breast cancer. We have designed and engineered a breast imaging system integrating both thermoacoustic and photoacoustic imaging techniques to achieve dual-contrast: …
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Clinical applications of quantitative photoacoustic imaging
Photoacoustic imaging is a medical imaging tool increasingly used in clinical research. It enables the imaging of molecules, including melanin, haemoglobin, lipids, collagen and water deep inside the body, with high resolution and high sensitivity. This molecular information has made it an …
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Multi-spectral Deep Tissue Quantitative Photoacoustic Imaging
<p>Photoacoustic tomography (PAT) detects the acoustic signals generated by optical absorption from chromophores. Using oxy- and deoxy-hemoglobin, multi-spectral PAT can image vasculature structure, and provide functional information. Most of the current PAT imaging studies face four challenges: …
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Validation of photoacoustic imaging biomarkers in cancer biology
… not yet been fully understood. Harnessing the photoacoustic effect, photoacoustic imaging (PAI) holds significant potential to elucidate these dynamics, but to fulfil this potential, a need for a thorough technical and biological validation arises. This thesis presents technical validation of …
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A Low-cost Microvascular Phantom for Photoacoustic Imaging Using Loofah
<p>Existing photoacoustic phantoms are inadequate for mimicking the complex microvascular structures found in human tissue due to their inability to replicate varying sizes and distri- butions of vasculature. This limitation underscores the need for a new material capable of replicating intricate …
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Development of Quantitative Molecular Photoacoustic Imaging For Noninvasive Cancer Diagnostics
<p>Traditional diagnostic imaging provides clinicians with anatomical information that guides both diagnosis and treatment planning; however, once a tumor has progressed enough to be visible, it has often reached an advanced stage. Molecular imaging techniques allow for real-time visualization of …
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Ultrasound and photoacoustic imaging to guide and monitor photothermal therapy
… relevant, there is a need to develop an imaging technique to identify tissue composition and to detect the presence of photoabsorbers in the tumor volume before therapy; to monitor the temperature rise during therapy; and to assess the tumor damage after therapy. In this study, a combined …
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Deep Photoacoustic Imaging and Acoustic Cavitation Mapping in Shockwave Lithotripsy
… may result in renal vascular injury. Current imaging modalities used in SWL (e.g., C-arm fluoroscopy and B-mode ultrasound) are not sensitive to vascular injuries. To better understand the mechanism of tissue injury and improve treatment safety and efficiency, it is highly desirable to …
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Development of small-molecule probes for photoacoustic imaging of hypoxia
… and increased metastatic potential; thus, imaging tumor hypoxia has important implications in treatment planning and predicting patient prognosis. Herein we discuss our approach for hypoxia detection using photoacoustic (PA) imaging. This method combines the resolution of optical imaging …
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Photoacoustic imaging system for fluid flow visualization and biological tissues characterization
Photoacoustic (PA) imaging is a biomedical imaging modality, which work is based on the photoacoustic effect, to provide illumination of biological tissues with strong optical absorption contrast and high spatial resolution at a short scanning time. The drawbacks of some existing PA fluid imaging …
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Rational design of chemical tools for in vivo applications via photoacoustic imaging
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-15 without embargo terms
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Development of High-speed Photoacoustic Imaging technology and Its Applications in Biomedical Research
Photoacoustic (PA) tomography (PAT) is a novel imaging modality that combines the fine lateral resolution from optical imaging and the deep penetration from ultrasonic imaging, and provides rich optical-absorption–based images. PAT has been widely used in extracting structural and functional …
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Photoacoustic imaging: development of near infrared platforms for non-invasive deep-tissue imaging
"Fluorescence imaging has been employed as the gold-standard in molecular imaging. However, despite its ubiquitous usage, this technique is only viable for studying molecular interactions within a cellular system. Fluorescence imaging is limited by optical diffusion, at depths greater than 1 mm, …
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Advancing Photoacoustic Imaging Technology with Compact Source, Fluorescence Co-registration, Spectral Encoding, Matrix Detection and FRET
<p>Photoacoustic tomography, which detects non-radiative decay, is an emerging biomedical imaging modality that can provide 3D ultrasonically scalable images of biological tissue ranging from organelles to organs. Pure optical imaging modalities (e.g., optical coherence tomography and diffuse …
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High-Performance CMOS Front-End ASICs for SiPM Detectors and High-Frequency Ultrasound and Photoacoustic Imaging
… energy physics, positron emission tomography imaging, and light detection and ranging applications. The slow-rising edge of standard SiPM signal, however, makes the timing measurement sensitive to noise and leads to poor timing resolution. Besides, the SiPM energy measurement utilizing …
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Development of chemical tools for studying biology with light: Photoactivatable donors and photoacoustic probes
… towards activatable contrast agents for photoacoustic imaging, an emerging deep-tissue imaging modality. To address a lack of modular activatable probes for this imaging technique, we combined the analyte specificity of DNA aptamers with commercially available fluorophores to show the …
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Multi-modal molecular imaging of radiation therapy response in the tumour vascular microenvironment
… with systemic chemotherapy. Recent advances in imaging have enabled precise targeting of solid lesions, yet substantial intratumoural heterogeneity means that treatment planning and monitoring remains a clinical challenge as changes in tumour size can take weeks to manifest and may be …
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