Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 24 for “"phosphorylated tau"”.
-
Association between CSF Biomarkers and Performance on Neuropsychological Test in Patients with Mild Cognitive Impairment
… usually have decreased Aβ42 but increased total-tau (T-tau) and phosphorylated tau (P-Tau) in cerebrospinal fluid (CSF). To increase prognostic specificity of MCI to AD, studies have linked findings in CSF to neuropsychological profiles in MCI. The aim of this research was to find out if there is …
-
Studies of hyperphosphorylated tau aggregation and cytotoxicity
… aggregates of the microtubule-associated protein tau have been challenging to assemble and characterize, despite their important role in the development of tauopathies. We found that sequential hyperphosphorylation by protein kinase A in conjugation with either glycogen synthase kinase 3b or …
-
Proteomic-based Signature of Brain-related Proteins as Novel Candidate Biomarkers for Alzheimer’s Disease Diagnosis
… where core biomarkers amyloid beta 1-42, total tau, and phosphorylated tau protein levels are changed relative to cognitively normal elderly. There is a need for novel disease-specific biomarkers that will capture disease more accurately and at an earlier stage, predict disease severity, and be …
-
Characterization of the Dunkin Hartley guinea pig as a non-transgenic and multimorbid model of brain aging
… presence of an age related neuroinflammatory and phosphorylated tau phenotype. Findings from this study contribute to the overarching hypothesis that AD/ADRD is a whole-body disease, and ultimately support the goal of closing the existing translational gap between preclinical and clinical …
-
Multi-sensory gamma stimulation ameliorates Alzheimer's-associated pathology and improves cognition
… Additionally, auditory GENUS reduced phosphorylated tau in the tau P301S model. Finally, I demonstrate that combined auditory and visual GENUS, but not either alone, decreases amyloid and produces a microglial-clustering response in the medial prefrontal cortex. Whole brain analysis …
-
Investigating alterations in autophagy in Alzheimer’s disease using human brain tissue and skin-derived fibroblasts
… characterised by the accumulation of abnormally phosphorylated tau protein within neurofibrillary tangles and plaques containing amyloid-β (Aβ). Autophagy is a normal intracellular mechanism that functions to degrade damaged cellular proteins. Studies have shown that there is an association …
-
The functional role of the retromer complex in the pathogenesis of Alzheimer's disease in Down syndrome
… with DS develop amyloid beta (Aβ) plaques and tau neurofibrillary tangles, the pathological hallmarks of Alzheimer’s disease (AD). This increased susceptibility to Alzheimer’s Disease in Down syndrome (AD-DS) has primarily been attributed to an over-dosage of the amyloid precursor protein …
-
Investigating the Use of [18-F] tau-PET Imaging as a Biomarker of tau Pathology in Retired Athletes at Risk of Neurodegeneration
… is characterized by abnormal accumulation of tau protein in the brains of affected athletes in a pattern distinct from other neurodegenerative diseases. There is currently no in vivo biomarker of tau pathology of chronic traumatic encephalopathy, and the diagnosis is made post-mortem. [18-F] …
-
The Manipulation Of Apical Dendritic Plasticity And The Consequences For The Effects of Chronic Stress
… following chronic stress by multiple measures. Phosphorylated-Tau is present in the hippocampus of severely damages brains, such as during Alzheimer's disease. Tau binds to microtubules and helps support the backbone structure making up dendrites and axons. Tau phosphorylates in response to …
-
Neuropathological significance of PLD1 in Alzheimer's disease and behavioral variant frontotemporal dementia
… of amyloidogenic insults amyloid-β (Aβ) and tau in wildtype mice, implicating a role for PLD1 in synaptic deficits. Given this background, I implemented a 12-month-old 3xTg-AD mouse model; to corroborate a pathological role for PLD1 in AD where neuropathological hallmarks such as the Aβ and …
-
Glutamate Imaging of Mouse Models of Neurodegeneration
… diseases such as Alzheimer’s disease (AD), tauopathies, and Parkinson’s disease (PD). A non-invasive measurement of glutamate would enhance our understanding of neurodegenerative processes and potentially facilitate early diagnosis. The current method for measuring glutamate in vivo is …
-
Converging Pathways: Neuroimmunology of Tauopathy and Mild Traumatic Brain Injury
… set out to map the immune responses of a primary tauopathy and repeat head injury. Using high parameter flow cytometry and RNA sequencing of spinal cords from late stage P301S tauopathy mice, I found that primary tauopathy drives a microglial transition toward an antigen-presenting phenotype as …
-
Bioastronautics: Biological Modeling of the Neural Response to Space Radiation and its interaction with Alzheimer's Disease Risk Genes
… which captures the beta-amyloid (Aβ) and phosphorylated tau protein aggregation characteristic of the disease, for use with the particle accelerator facility at the NASA Space Radiation Laboratory (NSRL). We show consistent changes in Alzheimer’s protein pathology and marked differences in …
-
Novel roles of microtubule-associated tau in radiation-induced brain injury
… largely elusive. However, microtubule-associated tau, an important partner of cytoskeletal structural stability emerges as a pivotal player in the radiation-induced neuronal injury response, demonstrating compartmentalized functions such as repair-centric mechanisms and synaptic homeostasis. This …
-
Cognitive, Psychiatric, And Neuropathological Manifestations Of Repetitive Mild Traumatic Brain Injury
… progressive brain atrophy, accumulation of hyper-phosphorylated tau and aggregates of TDP-43, myelinated axonopathy, neuroinflammation and degeneration of white matter tracts. The relationship between head impact parameters (force, number, frequency) and the manifestations of rmTBI is not well …
-
Pathophysiological Mechanisms and Diagnostic Markers in Alzheimer’s Disease
… the course of disease, we analyzed CSF levels of phosphorylated tau (P-tau) and assessed WMLs on brain scans in healthy controls and patients with mild cognitive impairment. We found that a pathological level of P-tau and WMLs in the parietal lobes independently increased the risk of developing AD …
-
Cofilin-actin rods: quantification and comparison to tau pathology in a human longitudinal aging study and developing probes to measure localization and activity of NADPH oxidase 2, a component of the prion-dependent rod inducing pathway
… neurofibrillary tangles composed mainly of hyperphosphorylated tau protein, are used for post-mortem confirmation of the diagnosis of Alzheimer's disease (AD). However, a shift in disease hypothesis has changed over the years. It is now generally accepted that soluble forms of Aβ oligomers and …
-
The effects of physical function and genetics on cognition and blood biomarkers in individuals at-risk for Alzheimer’s disease and related dementias
… benefits with exercise. Additionally, plasma phosphorylated tau 217 (p-tau217) has been identified as a novel diagnostic ADRD biomarker which needs further research to examine associations with risk factors. Therefore, the aims of this investigation were (1) Understand if higher physical …
-
Clusterin: A Regulator of Glial Biology and Alzheimer’s Disease Pathogenesis
… β-amyloid (Aβ) plaques and intracellular hyper-phosphorylated tau (p-τ) in neurofibrillary tangles. Therapeutic efforts targeting Aβ and tau have yielded poor clinical results, raising questions about the suitability of these pathological features as drug targets. Microglia and astrocyte …
-
Apolipoprotein E and propagation of pathological tau in Alzheimer’s Disease
… of amyloid-b (Ab) in plaques and hyperphosphorylated tau in neurofibrillary tangles. This occurs alongside neuroinflammation and neurodegeneration. Clinically, AD is typified by cognitive decline. Pathological tau propagates through the AD brain in a defined manner, with indications …
Page 1 of 2