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Showing 1 to 20 of 97 for “"phosphonate"”.
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Mechanistic investigations of enzymes in phosphonate metabolism
Synthetic and naturally-occurring phosphonates have found widespread use in both agriculture and medicine. A program at the Institute for Genomic Biology at the University of Illinois at Urbana-Champaign was established to discover novel phosphonate natural products. In addition to this effort, the …
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Molecular characterization of phosphonate biosynthesis in nature
Phosphonates, compounds characterized by direct C-P bonds, comprise a structurally diverse class of natural products demonstrating an impressive range of biological activities. Although the first biologically produced phosphonate was described more than 50 years ago, the range and diversity of …
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Phosphonate natural products from host-associated enterobacteria
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Oxygen-dependent enzymes involved in phosphonate biosynthesis
… the rapid discovery and characterization of new phosphonate natural products. The work in this thesis focuses on the characterization of the enzymes needed for formation and functionalization of many different phosphonic acid biosynthetic pathways. Non-heme iron-dependent oxygenases are important …
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Diverse enzyme reactions in phosphonate natural product biosynthesis
… of new biosynthetic gene clusters encoding phosphonate natural products have been characterized by mining of microbial genomes. Phosphonates, which are characterized by their hydrolytically stable carbon-phosphorus bond, are prevalent in everyday life, such as in commercially available …
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Block and Graft Copolymers Containing Carboxylate or Phosphonate Anions
… and block copolymers containing carboxylate or phosphonate anions that are potential candidates for biomedical applications such as drug delivery and dental adhesives. Ammonium bisdiethylphosphonate (meth)acrylate and acrylamide phosphonate monomers were synthesized based on aza-Michael addition …
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Structural studies of enzymes involved in antibiotic resistance and phosphonate degradation
… linkage. Second examples are the phosphonate molecules which replace the high energy phosphoryl and carboxyl ester moieties of various enzyme intermediates by stable phosphonate linkages. These compounds in addition to possessing bioinhibitory activities are also thought to be …
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Investigation of the biosynthesis of the phosphonate antibiotics bialaphos and dehydrophos
Phosphonate and phosphinate natural products possess a range of biological activities as a result of their ability to mimic phosphate esters or tetrahedral intermediates formed in enzymatic reactions involved in carboxyl group metabolism. The widespread use in medicine and agriculture of these …
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Synthesis and Structural Studies of Calcium and Magnesium Phosphinate and Phosphonate Compounds
… of magnesium and calcium based phosphinate and phosphonates with possible applications as bone scaffolding materials or additives to bone cements. The challenge to the chemistry of the alkaline earth phosphonate target compounds includes poor solubility of compounds, and poorly understood …
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Synthesis and structural analysis of [alpha]-aminophosphonic acids and their phosphonate ester derivatives
… of novel [alpha]-aminophosphonic acids and their phosphonate ester derivatives. Compounds of these types are of interest because of their potential for biological activity, particularly in the area of agricultural chemistry. The second objective was to investigate the conformation of selected …
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Investigations into the biosynthesis and mode of action of the phosphonate antibiotic dehydrophos
Dehydrophos is a vinyl phosphonate tripeptide produced by Streptomyces luridus with demonstrated broad spectrum antibiotic activity. Dehydrophos antibiotic activity was determined to be dependent on uptake into the cell via non-specific oligopeptide permeases, followed by aminopeptidase catalyzed …
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Investigation of phosphonate biosynthesis: I. Structure of dehydrophos II. Mechanism of hydroxyethylphosphonate dioxygenase
Natural product phosphonates are used extensively in the clinic as antibacterials and in commercial agriculture as herbicides. In an effort to efficiently discover new natural product phosphonates, a multidisciplinary, collaborative program has been established at the Institute for Genomic Biology …
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Synthesis and Functionalization of Poly(ethylene oxide-b-ethyloxazoline) Diblock Copolymers with Phosphonate Ions
… based on the moles of acid. Diethyl vinyl phosphonate was attached to the nitrogen of PEI units via Michael addition where the phosphorylation left <1% of PEI units unattached. The ethyl groups on the phosphonates were further hydrolyzed off phosphonate with HCl acid leaving phosphonic …
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Phosphonate biogeochemical cycling in the marine environment: from an ocean scale to a molecular scale
… (P) redox cycle was recently confirmed when phosphonates, organophosphorus compounds with P in the (III) oxidation state, were found in high molecular weight dissolved organic matter. Although some features of the P redox cycle have come to light since the discovery of phosphonates, many …
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Phosphonate biogeochemical cycling in the marine environment: from an ocean scale to a molecular scale
… (P) redox cycle was recently confirmed when phosphonates, organophosphorus compounds with P in the (III) oxidation state, were found in high molecular weight dissolved organic matter. Although some features of the P redox cycle have come to light since the discovery of phosphonates, many …
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Structural analysis via X-ray crystallography of an engineered carbon methyltransferase, a phytoxic phosphonate and its modifying enzyme, and a chimeric tyrosinase
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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Functional Metal Phosphonates
… the incorporation of functionality into metal phosphonates. This was done in one of several ways. The first involved using phosphonate ligands that had covalently attached organic functional groups. In some cases, these ligands undergo reactions during the solvothermal syntheses which can …
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Non-Covalent Interactions in Polymeric Materials: From Ionomers to Polymer Blends
… multivalent pendant ions, such as divalent phosphonate. In this dissertation, poly(ethylene terephthalate) (PET) and polystyrene ionomers with divalent phosphonate pendant ions have been synthesized, and the influence of divalent phosphonate pendant ions on the structure-morphology-property …
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