Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"phospholipases"”.
-
Interaction of sPLA2 phospholipases with assemblies of natural and synthetic amphiphiles and the development of a drug delivery system for the treatment of breast cancer
Phospholipases hydrolyze the phosphodiester bonds of phospholipid substrates releasing fatty acids and lysophospholipids. Phospholipases can be classified into five superfamily enzymes based on their differences in hydrolyzing the substrate. One of them, phospholipase A2 (PLA2) cleaves the ester …
-
La redistribution de l'acide arachidonique dans les glycérophospholipides des lymphocytes T humains
… l'expression de certaines acyltransférases et phospholipases A2 chez les cellules T au repos et en prolifération."
-
Lipid catabolism in Treponema
… α-glycerophosphate was utilized by four species. Phospholipases A, C, and D, α-glycero-phosphate dehydrogenase, and alkaline phosphatase activities were not found in five species of Treponema. Based on the specific enzymes demonstrated in this study, two pathways of phospholipid catabolism are …
-
AVALIAÇÃO DA ATIVIDADE ANTILEISHMANIA DA PLA2 Lys49 MjTX-I, ISOLADA DA PEÇONHA DE Bothrops moojeni
… with therapeutic potential, among these, phospholipases A2 (PLA2) stand out. Thus, the objective of the present study was to evaluate the effect of PLA2 MjTX -I, isolated from Bothrops moojeni venom on the growth and viability of promastigote forms of Leishmania Leishmania amazonensis. In …
-
Phospholipase A2 Induced Monocyte Chemotaxis to Apoptotic Cells
… Products of the reaction catalyzed by the phospholipases A2 (PLA2) have been shown to induce monocyte chemotaxis either directly or indirectly. Some investigators have implicated a cytosolic calcium-independent PLA2 (iPLA2) in the production of these products during apoptosis. However, a …
-
L' effet polymorphisme d'un seul nucléotide (SNP) de la PLA2 de groupe IVC (cPLA2y) sur son activité enzymatique
"Les phospholipases présentent un rôle important dans l'hydrolyse de glycérophospholipides membranaires, contribuant à la diversité d'espèces moléculaires ainsi qu'au relâchement de molécules bioactives. Une phospholipase moins étudiée, la phospholipase de groupe IVC (cPLA2γ), fut …
-
Studies on the Molecular Biology of Naegleru Fowleri and Identification of N. Fowleri in the Environment
… resistance to complement lysis and production of phospholipases may account for pathogenicity of this ameba. Studies were performed to determine the gene encoding a complement regulatory protein, CD59, found in membrane fractions of N. fowleri. The genome of this organism has not been sequenced, …
-
Near Infrared Fluorescent Choline Kinase Inhibitors for Cancer Imaging and Therapy
… of competing catabolic contributions from the phospholipases, the relative role of ChoKa is not absolutely discernable in a clinical setting. The goal of this work was to develop ChoKa-specific imaging probes to assist in the development of ChoKa as a diagnostic biomarker and therapeutic …
-
Mouse modifiers of intestinal tumorigenesis
… the remaining resistance. To further probe how phospholipases impinge on intestinal cancers, we have studied tumorigen-sis in mice lacking group IV cytosolic phospholipase a2 (cPLA2). Crossing ApcMin into this background produces an 83% reduction in tumor number in ApcMin, cPLA2 -/- homozygotes, …
-
Prophylaxis of disease caused by bacterial pathogens of man
… into the structures and functions of related phospholipases C (the zincmetallophospholipases C) from other bacterial pathogens. This pioneering work with α-toxin is recognised by invitations to write reviews and book chapters on this subject and on bacterial phospholipases C. C. perfringens …
-
Laying the Genetic and Molecular Foundation for the Study of Fusobacterium Nucleatum in Relation to Human Health and Disease
… F. nucleatum outer membrane phospholipase, FplA. Phospholipases are important virulence factors in a number of well-studied human pathogens including Pseudomonas aeruginosa and Legionella pneumophila, where they interfere with host cellular signaling processes to increase intracellular bacterial …
-
Erwinia carotovora extracellular proteases: characterization and role in soft rot
… roles in pathogenesis, including cellulases, phospholipases, and protease(s). The objectives of this research were to (1) characterize Ecc extracellular protease (Prt) and (2) elucidate its role in potato soft rot. A gene encoding a Prt, <u>prt</u>1, was cloned from cosmid pCA7 containing Ecc …
-
The role of cytosolic phospholipase A2 in microglial signaling pathways during neuroinflammation
… phospholipase A2 (cPLA2) belongs to a family of phospholipases that act as the principle producers of arachidonic acid (AA) in cells. During the process of inflammation, AA released from phospholipids is metabolized by cyclooxygenase-1[slash]2 (COX1[slash]2) and lipoxygenases, and in turn can be …
-
The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism
… (PLA2G2A) is a member of a family of secretory phospholipases previously implicated in inflammation, atherogenesis, and antibacterial actions. These enzymes hydrolyze glycerophospholipids at the sn-2 position releasing lysophospholipids and fatty acids. Though studies have shown PLA2G2A is …
-
Defining genomic drivers of evolution in the entomopathogenic Serratia spp. A thesis submitted in partial fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… located accessory virulence determinants such as phospholipases, chitinases, and extracellular proteases in S. entomophila and S. proteamaculans are yet to be described. Bioinformatics and both in vitro (plate assays) and in vivo bioassays were used to assess accessory virulence factors …
-
Proteasome-Mediated Degradation of PNPLA3
Pages 33-49 are misnumbered as pages 34-50, pages 50-75 are misnumbered as pages 52-77, and pages 76-133 are misnumbered as pages 75-132.
-
Tobacco Phospholipase D β1: Molecular Cloning and Biochemical Characterization
Transgenic tobacco plants were developed containing a partial PLD clone in antisense orientation. The PLD isoform targeted by the insertion was identified. A PLD clone was isolated from a cDNA library using the partial PLD as a probe: Nt10B1 shares 92% identity with PLDβ1 from tomato but lacks the …
-
Identification of the Pla2 Responsible For Prostanoid Synthesis in Response to Inflammatory Cytokines
Preliminary studies from our laboratory showed that cPLA2α may be responsible for approximately 50-60% of the PGE2 production in response to inflammatory cytokines. Thus, we hypothesized that a closely-related PLA2 is responsible for 40-50% of the PGE2 produced in response to inflammatory …
Page 1 of 2