Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"phospholipase D (PLD)"”.
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Phospholipase D Signaling in T Cells
… of T lymphocytes induces the activation of phospholipase D (PLD) signaling. Phospholipase D (PLD) is a phosphodiesterase that catalyzes the conversion of phosphatidyl choline (PC) to phosphatidic acid (PA). PA is an important lipid second messenger and is known to mediate a variety of …
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D2R Dopamine Receptor Mediates Changes in Dual Specificity Phosphatase Expression in a Small Cell Lung Cancer Cell Line
… suggesting phosphatidic acid (PA) produced from Phospholipase D (PLD) is involved in this induction.</p>
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Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference
… studies have demonstrated a link between phospholipase D (PLD) and metabotropic glutamate receptors (mGluRs), while other studies show an interaction between dopamine receptors (DRs) and PLD. Therefore, we investigated the mechanisms of the dopamine agonist-induced synaptic plasticity that …
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Novel interactions of the 5-HT₂ₐ and related receptors with intracellular signalling proteins
… GPCRs. The receptor is known to activate phospholipase C (PLC) via the heterotrimeric G proteins Gaq/n, but has been shown to also signal through the phospholipase D (PLD) pathway in an ADP-ribosylation factor (ARF)-dependent manner, that appears to be independent of Gq/n. The M3 …
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Molecular and biochemical characterization of phospholipase D in cotton (Gossypium hirsutum L) seedlings.
… (NAPE) via the action of phospholipase D (PLD). In an effort to identify a functional NAPE-PLD in cotton seeds and seedlings, we have screened a cotton seedling cDNA (cotyledon mRNA from 48 h dark grown seedlings) library with a 1.2 kb tobacco partial cDNA fragment encoding …
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Novel anitbody-based assays for disease and food contaminant detection
… based on the detection of antibodies to a phospholipase D (PLD) exotoxin of Corynebacterium pseudotuberculosis, the causative agent of caseous lymphadenitis (CLA), were investigated. A previously cloned recombinant form of PLD (Menzies et al., 1994) was expressed in E. coli, purified and …
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The role of phospholipase D1 in trafficking and processing of amyloid precursor protein
… is produced by a variety of enzymes, including phospholipase D (PLD). We previously demonstrated that a PLD isoform, PLD2, is required for the synaptotoxic and memory-impairing actions of amyloid beta in an AD mouse model. The role that the other PLD isoform, PLD1, plays in AD is unclear, …
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Beteiligung der Phospholipase D an der Regulation der Synthese von Phosphatidylinositol-4,5-bisphosphat durch Arf- und Rho-GTPasen
The reaction product of phospholipase D (PLD), phosphatidic acid (PA), was found to stimulate phosphatidylinositol-4-phosphate-5-kinase (PIP-5-kinase) activity in vitro. In the present study, we have examined wether PLD affects the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) by …
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DEVELOPMENT AND APPLICATION OF CHEMOENZYMATIC TOOLS TO VISUALIZE MAMMALIAN PHOSPHOLIPASE D SIGNALING
… regulation of signal transduction pathways. Phospholipase D (PLD) enzymes are a critical signaling node responsible for production of the pleiotropic lipid second messenger phosphatidic acid via hydrolysis of phosphatidylcholine. It remains a mystery how this one lipid signal can cause such …
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Neuropathological significance of PLD1 in Alzheimer's disease and behavioral variant frontotemporal dementia
Aberrantly elevated levels of Phospholipase D (PLD) activity is well documented in neurodysfunctional disorders including Alzheimer’s disease (AD). Our lab established, for the first time, an elevated PLD1 expression in crude synaptosomes from AD post-mortem brains and further demonstrated the …
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Attenuation of Corynebacterium pseudotuberculosis by targeted mutagenesis of the phospholipase D gene.
A toxic phospholipase D (PLD), is thought to be an essential virulence determinant of Corynebacterium pseudotuberculosis, an animal pathogen which causes chronic, suppurative infections. In this study, PLD was purified from C. pseudotuberculosis biovar equi isolate 155 and the gene encoding PLD …
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Use of Bioinformatics to Investigate Abiotic Stress in Arabidopsis and to Design Primers for Pathogen Detection
… analysis was used to study the role of PLDα1 in drought stress in Arabidopsis. Second, a tool for designing and in-silico testing of primers for PCR-based pathogen detection will be discussed. Phospholipase D (PLD) has been implicated in a variety of stresses including osmotic stress and …
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Small gtp-binding proteins in insulin secretion
… regulatory roles for Arf6/ARNO in promoting phospholipase D [PLD], extracellular-regulated kinases [ERK 1/2], Rac1/Cdc42, NADPH oxidase [Nox], reactive oxygen species [ROS], dynamin-1 and cofilin [actin-severing protein] signaling steps in isolated beta-cells. </p> <p>Lastly, this work …
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Signal transduction by the 5-HT2A receptor and its H452Y polymorphic variant
… signalling pathways, including the activation of phospholipase C (PLC) and phospholipase D (PLD) via recruitment of the small G-protein ADP-Ribosylation Factor (ARF). This thesis focusses on protein:protein interactions and signalling mechanisms of the 5-HT2AR and H452Y-5-HT2AR receptor variant. …
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Structural and Inhibitor Binding Studies of Tyrosyl-DNA Phosphodiesterase 1
… humans. TDP1 is a monomeric protein from the phospholipase D (PLD) superfamily. TDP1 is involved in the repair of topoisomerase-mediated DNA damage during DNA replication and transcription. TDP1 is current inhibition target for improving the efficacy of cancer chemotherapy, as TDP1 also repair …
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The role of a monomer/dimer equilibrium and the C-terminal tail in regulating translocation of sphingosine kinase 1 to the plasma membrane of breast cancer cells
… to filopodia. Treatment of cells with either the phospholipase D (PLD) inhibitor, 5-Fluoro-2-Indolyl des-chlorohalopemide (FIPI), or the Gq inhibitor, YM254890 reduced translocation in response to phorbol myristate acetate (PMA), carbachol or S1P, suggesting that phosphatidic acid (PA) formation …
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Regulation of mTORC1 by phosphatidic acid: mechanism and structural insight
… inhibition or depletion of the mTORC1 regulator, phospholipase D (PLD), and is recapitulated with the addition of the PLD product phosphatidic acid (PA). Parallel mass spectrometry analysis independently identified DEPTOR as an mTOR binding partner dissociated by PA. Interestingly, I found that …