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Showing 1 to 20 of 46 for “"phosphoinositides"”.
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Protein Regulators of Phosphoinositides as Promoters of Cancer Metastasis
… require the actions of a family of lipids called phosphoinositides (PIs). Although structurally small molecules and minor components of the cellular lipidome, PIs are critical mediators of many cellular processes through their localization, abundance, and recruitment of effector proteins. The …
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Escherichia Coli as a New Platform for the Study of Phosphoinositides
<p>Phosphoinositides are membrane phospholipids involved in a wide variety of processes across the tree of life. In eukaryotic cells they function though their role as integral membrane components, anchors for proteins, membrane identity markers, and signaling molecules. Phosphoinositides are …
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Ca²⁺ and phosphoinositides regulations in α-actinin -4 F-actin binding.
… F-actin binding activity would be regulated by phosphoinositides. Five mutations of α-actinin-4, K122N, an alternative splice variant, K255E, T259I and S263P, have been reported to be involved in three human diseases, non-small lung cancer (NSCLC), small cell lung cancer (SCLC) and focal …
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Investigation of Phosphatidylinositols and Phosphoinositides Using Matrix- Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
… (PIs) and their phosphorylated forms, phosphoinositides (PIPs), which are critical regulators of cellular signaling, membrane dynamics, and cytoskeletal organization. Dysregulation of PIs and PIPs are implicated in various diseases, including atypical hemolytic uremic syndrome (aHUS), …
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FREQUENCY AND AMPLITUDE CONTROL OF CORTICAL OSCILLATIONS BY LIPID METABOLISM
… remains unclear. In my study, I report phosphoinositides traveling waves on the plasma membrane of rat basophilic leukemia (RBL) mast cells (Xiong et al. 2016). Sequential waves of phosphoinositides are generated by two phase-shifted phosphoinositide phosphatases namely synaptojanin 2 …
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Ubiquitin Modulates Tollip's PtdIns(3)P Binding and Dissociates the Dimeric State of C-Terminal Cue Domain
… domain of Tollip preferentially interacts with phosphoinositides with moderate affinity. Remarkably, we found that ubiquitin modulates Tollip's lipid binding. We have observed an ubiquitin dose-dependent inhibition of binding of Tollip to phosphoinositides and it does so specifically by blocking …
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Regulation of lipid signaling at the Golgi by the lipid phosphatases hSAC1 and OCRL1
Phosphoinositides are key lipid signaling molecules present in membranes of all eukaryotes. Different species of phosphoinositides serve as membrane signposts at distinct cellular compartments. This assymetric distribution of phosphoinositides is achieved by the presence of an elaborate set of …
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alpha-Actinin-4 and the podocyte: Implications for focal segmental glomerulosclerosis
… to filamentous actin is regulated by calcium and phosphoinositides. Binding of calcium decreases the association of alpha-actinin-4 with actin, while binding of PIP2 and PIP3 enhances this interaction. High-affinity variants of alpha-actinin-4 are very static compared to the wildtype protein, and …
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Illuminating Organellar and Molecular Organization of the Endomembrane System
… of mammalian late endocytic compartments. Phosphoinositides perform the pivotal role as identifiers for different membrane compartments. I show that phosphatidylinositol 3-phosphate is presnt on late endosomes while phosphatidylinositol 4-phosphate is presnt on some endolysosomes and …
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Interaction between DVAP, the orthologue of human VAPB, and Drosophila Sac1
… a role in regulating PI4P turnover in yeast and phosphoinositides are implicated in some neurodegenerative processes. In this PhD thesis, Sac1-DVAP interaction is used as the starting point to identify the mechanism that is altered when DVAP function is impaired. Thus, the possibility that the …
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Molecular Characterization and Loss-of-Function Analysis of an Arabidopsis thaliana Gene Encoding a Phospholipid-Specific Inositol Polyphosphate 5-Phosphatase
… signaling events. The enzymes that metabolize phosphoinositides can in some cases serve to terminate the signaling actions of phosphoinositides. The inositol polyphosphate 5-phosphatases (5PTases) comprise a large protein family that hydrolyzes 5-phosphates from a variety of inositol phosphate …
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A study on PIP5Kalpha degradation by Nedd4-1-mediated ubiquitination
… link of Nedd4 family to modulation of membrane phosphoinositides such as PIP2.
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Synaptojanin1 is involved in endolysosomal trafficking in cone photoreceptors
… pathways. We analyzed the distribution of the phosphoinositides PI(3)P, PI(4)P, PI(3,5)P2 and PI(4,5)P2 in wild type and nrca14 photoreceptors. We found that the distribution of these lipids in wild type photoreceptors is the same as in non-neuronal cell types; PI(3)P on endosomes, PI(4)P on …
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Structural and Functional Aspects of Dystroglycan During Agrin -Mediated Acetylcholine Receptor Clustering at the Mammalian Neuromuscular Junction
… the juxtamembrane region has an affinity for phosphoinositides.
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Molecular Determinants of TRP Channel Gating
… due to its involvement in temperature sensing. Phosphoinositides, a component of the plasma membrane that modulate the activity of various ion channels (including TRPV1), are cleaved in response to inflammatory signals. Their role in regulating TRPV1 activity is controversial. To address this …
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The Function of Phosphatidylinositol 4-Kinase III-Beta in Trypanosoma Brucei
… events result in a group of molecules known as phosphoinositides. These molecules are important in signal transduction, endocytosis, exocytosis, and protein trafficking. Two phosphatidylinositol 4-kinases are found in Trypanosoma Brucei. We have cloned the gene encoding the Type III …
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The 5' inositol phosphatase SHIP2 regulates EGF-elicited protrusion in MTLn3 cells
… 2). PI(3,4,5)P 3 and P][(4,5)P 2 are two major phosphoinositides at the plasma membrane and regulate a variety of cellular functions, including receptor signaling, membrane-cytoskeleton interactions and clathrin-mediated endocytosis. Here I have looked at the effects of knocking down SHIP2 in …
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Activation of lipid kinase VPS34 by Rab GTPases
… negative charge, lipid unsaturation and specific phosphoinositides activate both VPS34 complexes. While the autophagic complex I relies on an amphipathic helix in ATG14L for membrane association, the endocytic complex II uses mainly three aromatic loops in the Beclin 1 subunit to engage with …
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Structural basis for interactions of the Phytophthora sojae RxLR effector Avh5 with phosphatidylinositol 3-phosphate and for host cell entry
… by conserved RxLR motifs in the effectors and phosphoinositides (PIPs) resident in the host plasma membrane such as phosphatidylinositol 3-phosphate (PtdIns(3)P). Recent reports differ regarding the regions on RxLR effector proteins involved in PIP recognition. To clarify these differences, I …
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Probing the regulatory mechanisms of the actomyosin system in motile cells
… (PBP10) that binds preferentially to PIP2. Phosphoinositides can recruit actin-binding proteins to defined subcellular sites and alter their activity. Neutrophils, as well as developed Dictyostelium cells produce PIP3 in the plasma membrane at their leading edge in response to an external …
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