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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 50 for “"phosphoinositide 3-kinase"”.

  1. Investigating the isoform-specific role of phosphoinositide 3- kinase p110delta

    Nock, G.UCL (University College London)2008

    Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that regulate a diverse array of biological functions in every cell type by generating lipid second messengers. The PI3K family is comprised of multiple isoforms that are divided into three main classes; class I, II and III. All class I …

    ucl Repository record

  2. Interactome Analysis Identifies Novel Targets of Phosphoinositide 3-kinase (PI3K) that Mediate Astrocyte Neuroprotection

    Alqawlaq, Samih Ahmad2019

    … Here, a chemical genetics screen revealed phosphoinositide 3-kinase (PI3K) as a central player transducing ACM-mediated neuroprotection. To identify additional proteins contributing to the protective activity, endogenous neuronal PI3K was immunoprecipitated from astrocytes exposed to ACM or …

    toronto-retro Repository record

  3. The Effect of Manipulation of the Phosphoinositide 3-kinase Pathway on Axon Regeneration in vivo

    Evans, Rachel ShaneUniversity of Cambridge2020

    … has demonstrated that manipulation of the phosphoinositide 3-kinase (PI3K) pathway by transgenic knockout of phosphatase and tensin homolog (PTEN) promotes survival and regeneration of murine RGC axons in an optic nerve crush (ONC) model. However, translation issues are yet to be addressed. …

    cambridge Repository record

  4. A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids

    Sadiq, Barzan A.University of Cambridge2018

    … are a family (α, β, δ and γ) of ubiquitous lipid kinases that can be activated by cell surface receptors to 3-phosphorylate PI(4,5)P2 (phosphatidylinositol(4,5)-bisphosphate) and generate the signalling lipid PI(3,4,5)P3. The PI(3,4,5)P3 signal then activates a diverse collection of effector …

    cambridge Repository record

  5. The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling

    Kielkowska, Anna JadwigaUniversity of Cambridge2018

    … PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling Abstract Class I phosphoinositide 3-kinases (Class I PI3Ks) are essential players involved in the signalling events in the cell and are critical promoters of cellular growth, survival and metabolism. Once …

    cambridge Repository record

  6. The role of the class III phosphoinositide 3-kinase VPS34 in regulatory T cells and activated CD8+ T cells

    Courreges, ChristinaUniversity of Cambridge2020

    The class III PI3-kinase VPS34 is a mediator of endocytosis, trafficking of intracellular membranes and vesicles, and autophagy in various cell types. Given its central role in key cellbiological processes, we explored whether VPS34 is critical for immune cells by generating conditional knockout …

    cambridge Repository record

  7. B-Cell Adapter for Phosphoinositide 3-Kinase Is a Signaling Adapter in the Toll-Like Receptor/Interleukin-1 Receptor Superfamily

    Troutman, Ty Dale2016

    … obligate role in linking TLRs to activation of phosphoinositide 3-kinase (PI3K) through recruitment of PI3K to the signaling complex and relief of inhibitory influences on PI3K activity. Importantly, BCAP selectively mediates TLR signaling towards the PI3K branch without affecting signaling to …

    utswmed Repository record

  8. Systematic Analysis of Crosstalk in the PDGF Receptor Signal Transduction Network

    Wang, Chun-Chao2009

    … (PDGF) receptor signaling network, in which phosphoinositide 3-kinase (PI3K) and Ras/extracellular signal-regulated kinase (Erk) pathways are prominently activated. We show that, while PI3K signaling is insulated from crosstalk, PI3K enhances Erk activation in multiple ways. Whereas …

    ncsu Repository record

  9. Dual Inhibition of the PI3K/Akt and MEK5/ERK5 Pathways for the Treatment of Breast Cancer

    Wright, Thomas Douglas2020

    … frontiers. In particular, aberrations in the Phosphoinositide-3-kinase (PI3K) and Mitogen Activated Protein Kinase (MAPK) pathways have been linked to increased breast cancer proliferation and survival. It has been proposed that these survival characteristics are enhanced through compensatory …

    duquesne Repository record

  10. VOLUMETRIC GROWTH MODEL OF HUMAN MEDULLOBLASTOMA IN THE NUDE MOUSE CEREBELLUM

    Gavigan, Thomas2020

    … agent that inhibits Akt activation in the phosphoinositide 3-kinase (PI3K) pathway. In the orthotopic intracerebellar tumor model, perifosine significantly increased the survival of treated mice while qualitatively reducing leptomeningeal dissemination. In the flank model, perifosine …

    vcu Repository record

  11. Clinical Applications of Genomic Analyses in Prostate Cancer

    Crumbaker, MeganUNSW, Sydney2021

    … targetable pathways, androgen receptor and phosphoinositide 3-kinase, in prostate cancer and assesses their therapeutic implications. The fourth chapter of this thesis examines the real-world potential for whole genome sequencing and optical mapping data to inform treatment selection. …

    unsw Repository record

  12. Observing the effects of acetylcholinesterase and brain-derived neurotrophic factor on the levels of soluble amyloid precusor protein α in lung cancer cell media

    Coleman, Kai-ling Elle2023

    … were also found to be regulated by protein kinase C (PKC), extracellular signal-regulated kinase (ERK) 1/2, phosphoinositide 3 kinase (PI3K), but not protein kinase A (PKA).</p>

    emich Repository record

  13. Regulatory role of phosphatidylinositol 4-phosphate 5-kinases in brain inflammation

    김, 보경2011

    … by the type I phosphatidylinositol 4-phosphate 5-kinase (PIP5KI) family members, PIP5KIα, PIP5KIβ and PIP5KIγ, is an important regulator of diverse cellular processes at the cell surface, such as cell survival, cell proliferation, phagocytosis, macropinocytosis membraned ruffles, ion channels …

    ajou Repository record

  14. A lentiviral screen for novel regulators of IL-7R[alpha] in a pre-B cell line

    Trajman, Lily ChristineMassachusetts Institute of Technology2009

    … lentivirus-based shRNA library targeting murine kinases and phosphatases has allowed large scale screening for modulators of IL-7R[alpha][alpha] surface expression. This library provides shRNAs in the pLKO. 1 lentiviral vector targeting 1278 known kinases and phosphatases. Analysis of the …

    mit Repository record

  15. T Cell Intrinsic BCAP Links IL1R to the PI3K-mTOR Pathway and Regulates Pathogenic Th17 Differentiation

    Deason, Krystin LeighUT Southwestern Medical Center2018

    … a TIR domain in the protein B cell adaptor for phosphoinositide 3-kinase (BCAP) and determined a role for BCAP in the TLR signaling pathway in myeloid cells. Due to the shared use of TIR domains by TLR and IL1R signaling pathways, I hypothesized that BCAP would also be involved in signaling …

    utswmed Repository record

  16. The role of Serum- and Glucocorticoid kinase in the hormonal control of sodium transport in pulmonary epithelia

    Watt, Gordon B.University of Dundee2011

    … a central role for serum- and glucocorticoid-kinase(SGK1). The activity of this kinase is dependent upon phosphorylation of two distinct residues by the target of rapamycin complex 2 (TORC2) and phosphoinositidedependent Kinase 1 (PDK1), both of which are dependent upon …

    dundee Repository record

  17. Synthetic Studies on Small Molecule Modulators of Src Homology 2 (SH2) Domain-Containing Inositol 5’-Phosphatase (SHIP)

    Dungan, Otto Milhous

    … as a new method to directly influence the phosphoinositide 3-kinase (PI3K) cell signaling pathway. Modulation of this pathway may be utilized in the development of interesting new therapeutics. A better understanding of the role that SHIP phosphatase activity plays in a number of disease …

    syracuse-diss Repository record

  18. The role of VIP family members in diabetic retinopathy

    MAUGERI, GRAZIAUniversità degli studi di Catania2018

    … the integrity of BRB through the activation of phosphoinositide 3 kinase (PI3K)/Akt and mammalian mitogen activated protein kinase/Erk kinase (MAPK/ERK) survival signaling pathways. Overall, these data indicate that these peptides, both in vivo and in vitro, perform a beneficial effect to …

    catania Repository record

  19. Regulation of LFA-1 on T cells by phosphoinositide signalling

    Johansen, KristofferUniversity of Cambridge2021

    … of T cells. LFA-1 activation is mediated by phosphoinositide 3-kinase (PI3K) and the downstream phosphoinositide PtdIns(3,4,5)P3 (PIP3). To investigate how PI3K regulates LFA-1, I optimised CRISPR/Cas9-mediated mutagenesis in T cells, and designed a retroviral library of CRISPR/single guide …

    cambridge Repository record

  20. Methods to Improve Virtual Screening of Potential Drug Leads for Specific Pharmacodynamic and Toxicological Properties

    LIEW CHIN YEE2011

    … such as lymphocyte-specific protein tyrosine kinase inhibitors (Lck) and phosphoinositide 3-kinase inhibitors (PI3K). Further investigated were toxicological data sets such as eye and skin irritation, compounds that produce reactive metabolites, and hepatotoxicity. To the best of our …

    nus Repository record

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