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Showing 1 to 5 of 5 for “"phosphoester"”.
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Synthesis of Chemical Models of Hydrolase Enzymes for Intramolecular Catalysis.
<p>Most nuclease enzymes can hydrolyze phosphoester bonds (in DNA and RNA) by using metal ions cofactors that coordinate and activate water molecules in the enzymes' active sites. However, there are some hydrolase enzymes (including nucleases) that can function without the aid of metal ions. …
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Synthetic coenzymes for in vitro selection of DNA enzymes.
… deoxyribozymes in the hydrolysis of a target RNA phosphoester. It was hoped that careful design would provide these molecules with a balance of solubility, binding, and catalytic power. These synthetic coenzymes were included in combinatorial selection experiments aimed at isolating …
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Design of new tripodal ligands to advance the biomimetic Zinc chemistry
… species. The ability of L3Zn-OH to cleave phosphoester bonds has been demonstrated by its reaction with tris(p-nitrophenyl)phosphate. L3Zn-OH did not promote the hydrolytic cleavage of amide bonds. The structure determination of a TpZn-acetamide complex has demonstrated the ability of the …
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Coordination Geometries in Metallobundles Enforcing Oxidative and Hydrolytic Catalysis and Designing Biomaterials for Use As Antimicrobials
… hydrolase bridging a heteronuclear metallosite. Phosphoester substrates were introduced to DFsc and UFsc to characterize hydrolase features. Defining the structural and functional properties of hydrolases in DF proteins would facilitate creation of catalysts for bioremediation purposes. We …
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Mechanisms of polyphosphate degradation
The goal of my research has been to investigate the mechanisms by which inorganic polyphosphate (polyP) is degraded in vivo. PolyP is a linear chain of phosphate moieties linked through high-energy phosphoanhydride bonds and can range in size from three-phosphates-long to thousands. Naturally, …