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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 139 for “"phosphodiesterase"”.
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Potential Natural Product Phosphodiesterase Inhibitors
… studies set forth to investigate the role of phosphodiesterase (PDE) enzyme inhibitors in sexual dysfunction and mood regulation. First, naturalproducts were screened by computer modeling of PDE5A1. Second, compounds were isolated from a plant traditionally used as an aphrodisiac. Third, a new …
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Hormonal regulation of phosphodiesterase 3B in adipocytes
… induced activation of the cAMP degrading enzyme phosphodiesterase (PDE) 3B in adipocytes is important for insulin mediated inhibition of lipolysis. The aim of this thesis was to contribute with knowledge on the acute activation of PDE3B in response to insulin and catecholamines in adipocytes. The …
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An investigation of phosphodiesterase activities in plant sources
Thesis (M.S.)--Michigan State University. Dept. of Biochemistry, 1968
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Action of Spleen Phosphodiesterase Upon Soluble Ribonucleic Acid
Made available in DSpace on 2014-12-09T17:35:32Z (GMT). No. of bitstreams: 1 6612338.pdf: 3133505 bytes, checksum: a07d5447085a9fb1d4be79483da474c9 (MD5) Previous issue date: 1966
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Functional characterization of Phosphodiesterase-4A in behavior and obesity
… has been reached with therapeutics for AD. Phosphodiesterases (PDEs) may be a potential novel target for future therapeutics aimed at combatting these psychiatric illnesses and neurodegenerative diseases. PDEs are a "super family" of 11 smaller enzyme families expressed throughout the body …
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Characterization of the Escherichia Coli Acyl Carrier Protein Phosphodiesterase
The activity of AcpH was also examined in relation to the toxicity of N-pentylpantothenamide, an analog of the CoA precursor pantothenic acid. This analog is known to be a substrate for three CoA synthetic enzymes, resulting in a CoA analog with a metabolically inactive prosthetic group …
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Type-5 Phosphodiesterase Inhibition in the Prevention of Doxorubicin Cardiomyopathy
… are designed to determine if sildenafil, a phosphodiesterase-5 inhibitor and known mitochondrial KATP channel opener, would protect against chronic doxorubicin cardiomyopathy both in vivo and in vitro.Male ICR mice were randomized to 1 of 4 treatments: saline, sildenafil (0.7 mg/kg IP), …
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Trace phosphodiesterase contamination of commercially prepared E. coli alkaline phosphatase
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Putative phosphodiesterase inhibitors as potential new chemotherapies against African Trypanosomiasis
… chemotherapies is compelling and urgent. Phosphodiesterase (PDE) enzymes degrade the secondary signalling molecule cyclic adenosine monophosphate (cAMP) to AMP by hydrolysis, thereby modulating and regulating the signal transduction to the effector proteins. The phosphodiesterase enzymes …
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Structural and Inhibitor Binding Studies of Tyrosyl-DNA Phosphodiesterase 1
… in this thesis has focused on human tyrosyl-DNA phosphodiesterase 1 (TDP1), which is a DNA repair enzyme that is present in eukaryotes including humans. TDP1 is a monomeric protein from the phospholipase D (PLD) superfamily. TDP1 is involved in the repair of topoisomerase-mediated DNA damage …
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Role of second generation phosphodiesterase inhibitors on mammalian sperm mobility
… this condition. Over 20 years ago, non-selective phosphodiesterase inhibitors (PDEi), such as pentoxifylline, were shown to enhance motility of human spermatozoa; however, contradictory results and stimulation of premature acrosome reaction has precluded their clinical use. Advancement in our …
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Action of Tyrosyl DNA Phosphodiesterase on 3'-Phosphoglycolate Terminated DNA Strand Breaks
… induced DSBs. Human and yeast tyrosyl DNA-phosphodiesterase (Tdpl) efficiently processed substrates with 3'-PGs, in either the presence or absence of magnesium, to give a 3'-phosphate. Gel filtration chromatography and western blotting codmed that the putative enzyme in human extracts that …
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PATHOGENIC ROLE OF PHOSPHODIESTERASE TYPE 5 UPREGULATION IN CARDIAC ISCHEMIA/REPERFUSION INJURY
Phosphodiesterase Type 5 (PDE5) inhibitors are cardioprotective against ischemia/reperfusion (I/R) injury. However, it remains uncertain if I/R affects PDE5. We hypothesized that generation of reactive oxygen species (ROS) during I/R leads to upregulation of PDE5, which contributes to pathological …
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THE ROLE OF PHOSPHODIESTERASE 3B IN CAMP-MEDIATED REGULATION OF INSULIN SECRETION
… to investigate the role of ?-cell cAMP-degrading phosphodiesterase 3B (PDE3B) in the regulation of insulin secretion and whole body energy homeostasis. The specific aims were (i) to study the physiological importance of well-regulated ?-cell-cAMP levels for insulin release and whole body energy …
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Phosphodiesterase 4 inhibitors for the treatment of inflammation associated with respiratory disease
… 1998 and 2002 focuses on the selection of novel phosphodiesterase 4 (PDE4) inhibitors for the treatment of inflammation associated with respiratory diseases such as asthma and chronic obstructive pulmonary disease. A number of issues, relevant at the time, have been considered including: a) in …
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Investigating the effect of phosphodiesterase inhibitors on human sperm motility and function
Assisted reproductive technologies (ART) have rapidly progressed through the years and it is becoming increasingly apparent that the main cause of infertility is male factor. Today, ICSI represents most treatment which itself demonstrates the severity of male infertility. This may include problems …
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Characterization of a glycerophosphodiester phosphodiesterase in the human malaria parasite Plasmodium falciparum
… in P. falciparum, a glycerophosphodiester phosphodiesterase (PfGDPD), involved in the downstream pathway of phosphatidylcholine degradation. PfGDPD hydrolyzes deacylated phospholipids, glycerophosphodiesters to glycerol-3-phosphate and choline. In this study, we have characterized PfGDPD …
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Investigating the Role of Phosphodiesterase 1C in Vascular Smooth Muscle Cell Migration and Invasion
… the critical role of cyclic nucleotide phosphodiesterase 1C (PDE1C) in HASMC migration, proliferation, and extracellular matrix adhesion. Here, we directly tested the hypothesis that cAMP signaling, and specifically PDE1C, influences the ability of activated/synthetic HASMCs to invade …
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PHOSPHODIESTERASE-5 INHIBITION: A NOVEL STRATEGY TO IMPROVE STEM CELL THERAPY IN THE HEART
… Recent studies have shown that inhibition of phosphodiesterase-5 (PDE-5) is a powerful strategy to precondition the heart and cardiomyocytes against ischemia/reperfusion injury. We therefore tested the hypothesis that inhibition of PDE-5 with sildenafil (Viagra®) or selective knockdown with a …
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