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Showing 1 to 8 of 8 for “"phosphatidylinositol-4-phosphate 5-kinase"”.
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Phosphatidylinositol 4-phosphate 5-kinase Involved in Neuroglial Toll-like Receptor Signaling
… studied. It was previously demonstrated that phosphatidylinositol 4,5-bisphosphate (PIP2), a membrane lipid produced mainly by the type I phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family members, was necessary for TLR4 signaling. However, details of the PIP5K-mediated PIP2 production …
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Differential Regulation of Phosphatidylinositol 4-Phosphate 5 Kinase Beta during Hypertonic and Oxidative Stress
… role in regulating cellular homeostasis. The phosphatidylinositol derivative, PI(4,5)P2 (PIP2)is an essential mediator of cellular processes such as signal transduction, membrane traffic, actin cytoskeleton, ion homeostasis, growth and apoptosis. Despite the importance of this signaling …
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The localisation and regulation of phosphatidylinositol-4-phosphate 5-Kinase gamma splice variants and the discovery of a new mammalian splice variant, PIP5KIγ_v6
Type I PIP kinases (phosphatidylinositol 4-phosphate 5-kinases, PIP5Ks) catalyse the majority of cellular synthesis of PI(4,5)P2. To date, three mammalian isoforms (r1, r2, r3) have been found. PIP5KIr is subject to complex C-terminal splice variation, enhancing its transcriptional diversity …
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A study on PIP5Kalpha degradation by Nedd4-1-mediated ubiquitination
Phosphatidylinositol 4,5-bisphosphate (PIP2) is a critical lipid mediator of diverse membrane processes including vesicle trafficking, actin cytoskeleton dynamics and cell signaling at the cell surface, indicating significance of spatiotemporal regulation and underlying mechanism of PIP2 …
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Type I PIP5Kα negatively regulates NGF-induced neurite outgrowth in PC12 cells
"Type I phosphatidylinositol 4-phosphate 5-kinase (PIP5KI) is responsible for the production of a membrane lipid, phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5]P2). Here, I have examined whether PIP5KIα, an isoform of PIP5Kα, plays a role in neurite outgrowth. For this, I generated a stable …
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Regulatory role of phosphatidylinositol 4-phosphate 5-kinases in brain inflammation
Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], mainly produced by the type I phosphatidylinositol 4-phosphate 5-kinase (PIP5KI) family members, PIP5KIα, PIP5KIβ and PIP5KIγ, is an important regulator of diverse cellular processes at the cell surface, such as cell survival, cell proliferation, …
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Beteiligung der Phospholipase D an der Regulation der Synthese von Phosphatidylinositol-4,5-bisphosphat durch Arf- und Rho-GTPasen
… phosphatidic acid (PA), was found to stimulate phosphatidylinositol-4-phosphate-5-kinase (PIP-5-kinase) activity in vitro. In the present study, we have examined wether PLD affects the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) by PIP-5-kinase. Overexpression of PLD isoforms in …
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Distinct roles of PI4P 5-kinase isoforms in polar tip growth of pollen tubes
Das Phospholipid Phosphatidylinositol-4,5-bisphosphat (PI(4,5)P2) kommt in wachsenden Pollenschläuchen vorwiegend in der apikalen Plasmamembran der Spitze vor. Welche Enzyme PI(4,5)P2 an dieser Stelle synthetisieren und welche Funktionen dieses Signallipid hat, war bislang unbekannt. Daher wurden …