Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"phosphatidylinositol 4-phosphate"”.
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Regulatory role of phosphatidylinositol 4-phosphate 5-kinases in brain inflammation
Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], mainly produced by the type I phosphatidylinositol 4-phosphate 5-kinase (PIP5KI) family members, PIP5KIα, PIP5KIβ and PIP5KIγ, is an important regulator of diverse cellular processes at the cell surface, such as cell survival, cell proliferation, …
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Phosphatidylinositol 4-phosphate 5-kinase Involved in Neuroglial Toll-like Receptor Signaling
… studied. It was previously demonstrated that phosphatidylinositol 4,5-bisphosphate (PIP2), a membrane lipid produced mainly by the type I phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family members, was necessary for TLR4 signaling. However, details of the PIP5K-mediated PIP2 production …
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Functions of Phosphatidylinositol 4-Phosphate 5 Kinases in Actin Cytoskeletal Regulation During Phagocytosis
Phosphatidylinositol (4,5)-bisphosphate (PIP2) is a crucial signaling phosphoinositide at the plasma membrane (PM) which mediates a variety of biochemical activities and cellular functions. It is primarily synthesized by type I phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) through the …
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Differential Regulation of Phosphatidylinositol 4-Phosphate 5 Kinase Beta during Hypertonic and Oxidative Stress
… role in regulating cellular homeostasis. The phosphatidylinositol derivative, PI(4,5)P2 (PIP2)is an essential mediator of cellular processes such as signal transduction, membrane traffic, actin cytoskeleton, ion homeostasis, growth and apoptosis. Despite the importance of this signaling …
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The localisation and regulation of phosphatidylinositol-4-phosphate 5-Kinase gamma splice variants and the discovery of a new mammalian splice variant, PIP5KIγ_v6
Type I PIP kinases (phosphatidylinositol 4-phosphate 5-kinases, PIP5Ks) catalyse the majority of cellular synthesis of PI(4,5)P2. To date, three mammalian isoforms (r1, r2, r3) have been found. PIP5KIr is subject to complex C-terminal splice variation, enhancing its transcriptional diversity …
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The Role of ER-Golgi Membrane Contact Sites and of FAPP1 in Phosphoinositide Homeostasis at the Golgi Complex
… to be a precursor for highly phosphorylated phosphatidylinositol species, phosphatidylinositol 4-phosphate (PI4P) turned out to be “active” in its own right as a pivotal regulator of multiple cellular functions including membrane trafficking, sphingolipid metabolism, autophagy, and cell …
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A study on PIP5Kalpha degradation by Nedd4-1-mediated ubiquitination
Phosphatidylinositol 4,5-bisphosphate (PIP2) is a critical lipid mediator of diverse membrane processes including vesicle trafficking, actin cytoskeleton dynamics and cell signaling at the cell surface, indicating significance of spatiotemporal regulation and underlying mechanism of PIP2 …
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Type I PIP5Kα negatively regulates NGF-induced neurite outgrowth in PC12 cells
"Type I phosphatidylinositol 4-phosphate 5-kinase (PIP5KI) is responsible for the production of a membrane lipid, phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5]P2). Here, I have examined whether PIP5KIα, an isoform of PIP5Kα, plays a role in neurite outgrowth. For this, I generated a stable …
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Targeting Plasma Membrane Phosphatidylserine Content to Inhibit Oncogenic Kras Function
… ORP8 exchange PtdSer synthesized in the ER for phosphatidylinositol-4-phosphate (PI4P) synthesized in the PM. We show that depletion of ORP5 or ORP8 reduced PM PtdSer levels, resulting in extensive mislocalization of KRAS from the PM. Concordantly, ORP5 or ORP8 depletion significantly reduced …
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Molecular mechanisms of exosome secretion
… secretion. We found that the conversion of phosphatidylinositol-3-phosphate (PI(3)P) to phosphatidylinositol-4-phosphate (PI(4)P) catalyzed by Myotubularin 1 (MTM1) and phosphatidylinositol 4-kinase type IIα (PI4KIIα) on the surface of MVEs mediates the recruitment of the exocyst complex. …
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Illuminating Organellar and Molecular Organization of the Endomembrane System
… for different membrane compartments. I show that phosphatidylinositol 3-phosphate is presnt on late endosomes while phosphatidylinositol 4-phosphate is presnt on some endolysosomes and lysosomes. This yields clues about how phosphoinositides regulate membrane sorting and biogenesis of different …
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PI(4)P-Dependent Recruitment of Clathrin Adaptors to the Trans-Golgi Network
… found that the Golgi is particularly enriched in phosphatidylinositol 4 phosphate [PI(4)P] and that the clathrin adaptor AP-1 binds PI(4)P directly, suggesting that PI(4)P binding may specify the TGN-specific recruitment in conjunction with Arf1. My studies showed that another monomeric clathrin …
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Beteiligung der Phospholipase D an der Regulation der Synthese von Phosphatidylinositol-4,5-bisphosphat durch Arf- und Rho-GTPasen
… phosphatidic acid (PA), was found to stimulate phosphatidylinositol-4-phosphate-5-kinase (PIP-5-kinase) activity in vitro. In the present study, we have examined wether PLD affects the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) by PIP-5-kinase. Overexpression of PLD isoforms in …
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The Role of FAM21 in the Regulation of Mitochondrial Dynamics
… work has also highlighted the contribution of phosphatidylinositol 4-phosphate (PI4P) trafficking, from trans-Golgi network vesicles (TGNv) and lysosomes, at the mitochondrial fission site during the last steps of the process. However, how the actin machinery is recruited and how PI4P could …
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Role Of Type Ii Phosphatidylinositol 4-Kinases In Endosomal Tubule Dynamics During Melanosome Biogenesis
… entirely known, but several studies suggest that phosphatidylinositol-4-phosphate (PtdIns4P) and the type II PtdIns-4-kinases, PI4KIIα and PI4KIIβ, may play a role. Moreover, PI4KIIα and PI4KIIβ interact respectively with AP-3 and AP-1, both of which control BLOC-1-dependent cargo sorting. We …
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PIP5-Kinase Dependent PIP2 Generation Impairs T Cell Activation by Rigidifying the Actin Cortex
… are spatially and temporally regulated by phosphatidylinositol 4,5-bisphosphate (PIP2) (Sechi et al, 2000; Yin et al., 2003; Logan et al., 2006). How actin dynamics is regulated by PIP2 in T cell activation is unclear. Generation of PIP2 at the plasma membrane can be accomplished by the …
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Novel Insights into the Role of the Smoothened Cysteine Rich Domain in Hedgehog Signalling
… to regulate intracellular signalling. Phosphatidylinositol-4-phosphate (PI(4)P) has been shown to regulate Smo activation. We determined that the fatty-acid side chains of the phosphatidylinositols interact with Smo CRD, and PI(4)P specifically enhances activator induced Hh signalling. …
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Novel regulators of trafficking in the yeast Golgi-endosomal system
… poorly understood. It has been demonstrated that phosphatidylinositol 4-phosphate (PI(4)P) generated by the PI(4)-kinase Pik1p plays an essential role in maintenance of Golgi secretory function and morphology. Up to now relatively few targets of Pik1/PI(4)P signaling at the Golgi have been …
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Role of trans-Golgi network vesicles in mitochondrial fusion
… fusion site. A screen examining the set of phosphatidylinositol phosphate (PIP) species as potential regulators of mitochondrial morphology uncovered the localization of phosphatidylinositol (3,4)-bisphosphate [PI(3,4)P2] in close proximity to the mitochondrial network. PI(3,4)P2 is produced …
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The Arf GTPase exchange factor Sec7p interaction network:
… from yeast to mammals. Both Arf regulation and phosphatidylinositol 4-phosphate (PI4P) metabolism are important factors for Golgi function. Here, we show that the yeast PI4-kinase, Pik1p binds specifically to Sec7p but not Gea1p or Gea2p. Taken together, the physical interaction, the …
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