Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 71 for “"phosphatidylinositol 3-kinase"”.
-
Designing Compounds that Probe the Phosphatidylinositol 3-Kinase Signalosome
Phosphoinositide 3-kinases (PI3K) are major regulators of many cellular functions, and its hyperactivation is a major target for anticancer drug discovery. PI3Kα is the isoform most implicated in cancer, and this thesis is dedicated to investigating how specific protein-ligand interactions in the …
-
EPIGENETIC REGULATION OF MICROGLIAL PHOSPHATIDYLINOSITOL 3-KINASE PATHWAY INVOLVED IN SYNAPTIC PLASTICITY IN RODENTS
… central nervous system (CNS). Microglia express phosphatidylinositol 3-kinase (PI3K), shown to play a significant role in synaptic plasticity in neurons. This study shows that the microglial PI3K/AKT pathway is epigenetically regulated through miRNA targeting by miR-21-5p and histone …
-
ER Stress is Linked to the Regulation of Hepatic Gluconeogenesis and Phosphatidylinositol 3-kinase/Akt Signaling Post Burn Injury
Burn injury is a severe form of trauma that causes changes in glucose metabolism. Glucose metabolism is controlled during early burn injury but later results in stress induced diabetes. We have shown that this is due to differential regulation of the insulin signaling pathway in the liver.
-
Insulin Receptor Substrate-1 Serine Phosphorylation by a Novel Phosphatidylinositol-3'-Kinase-Associated Serine Kinase Regulates Insulin and Interferon Receptor Signaling
The data in this thesis demonstrate that phosphatidylinositol 3 '-kinase (PI 3- kinase) associates with a novel serine kinase that can phosphorylate IRS-1 and reduce its ability to act as a substrate for insulin and interferon alpha (IFNalpha) receptors. PI 3-kinase is shown to associate with a …
-
Design, Synthesis, and Screening of Novel Phosphatidylinositol 3-Kinase (PI3K) Inhibitors Activated by Prostate Specific Antigen (PSA): Prodrug Treatment for Androgen-Independent Prostate Cancer
The PI3K/Akt pathway is one of the most frequently dysregulated signaling pathways in cancer and remains a crucial target in drug development. Current therapeutic drugs are potent, but often lack the cellular specificity needed to lower toxicity effects. Here we show the design and synthesis of two …
-
Age-Related Effects on the Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways in Breast Cancer and the Characterization of Novel MEK5 Inhibitors
… changes in the extracellular signal-regulated kinases, ERK1/2 and ERK5, of the mitogen-activated protein kinase (MAPK) pathway, and in the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway. Further, the role of the MEK5-ERK5 cascade in breast cancer cell proliferation, migration, and …
-
Biochemische Analysen zur Funktion und Regulation von Cytohesin-1 in humanen T-Zellen
… und vermittelt die Membranrekrutierung über Phosphatidylinositol- (3,4,5)-trisphosphat, dem Produkt der Phosphatidylinositol-3-Kinase. Die Phosphoinositidvermittelte Membranbindung wird primär von der PH-Domäne bewirkt, jedoch wird diese Funktion von der carboxyterminalen polybasischen …
-
Cell cycle checkpoints and checkpoint kinases in the apicomplexan parasites Plasmodium and Toxoplasma
… mechanisms and identifying potential checkpoint kinases is, therefore, essential to understanding how *P. falciparum* resists this frontline drug. Checkpoints are essential to maintaining growth and genetic stability in many other eukaryotic cells. Whether these checkpoints are as essential in …
-
Molecular Mechanism of Tetraspanin CD9 Mediated Cell Motility
… cell migration. Our findings show that the phosphatidylinositol-3 kinase (PI-3K) inhibitors, wortamannin and LY294002 inhibited CD9 promoted cell motility in Chinese hamster ovary (CHO) cells. In contrast, inhibitors targeting protein kinase C or mitogen-activated protein kinase had no …
-
Role of Laminins in the Development of the Peripheral Nervous System
… laminin-null Schwann cells exhibit reduced phosphatidylinositol 3-kinase activity and activation of caspase cascades, leading to apoptosis. Injection of a laminin peptide into mutant sciatic nerves partially restores PI 3-kinase activity and reduces apoptotic signals. In a Schwann …
-
PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy
… and regeneration of the remnant liver. Phosphatidylinositol 3-kinase (PI3K), composed of a p85ƒÑ regulatory and a p110ƒÑ catalytic subunit, participates in multiple cellular processes, including cell growth and survival; however, the role of PI3K in liver regeneration has not been …
-
The Effects of PTEN Deletion on Cell Size and Plasticity in the Hippocampus
… (PTEN) is the central negative regulator of the phosphatidylinositol 3-kinase (PI3K) -signaling pathway, which mediates diverse processes in various tissues. In the nervous system, the PI3K pathway modulates proliferation, migration, cellular size and synaptic transmission and plasticity. …
-
Effects of Rosemary Extract and Rosemary Extract Polyphenols on Skeletal Muscle Insulin Resistance
… transporters to the plasma membrane through the phosphatidylinositol-3 kinase (PI3K)/Akt signaling pathway. Impaired PI3K/Akt signaling is associated with skeletal muscle insulin resistance (IR), leading to chronically elevated blood glucose levels followed by a compensatory rise in insulin …
-
Molecular Basis of HDL-Mediated Endothelial Cell Migration and Reendothelialization
… and it is dependent on the activation of Src kinases, phosphatidylinositol 3-kinase, and p44/42 mitogen-activated protein kinases. Rapid initial stimulation of lamellipodia formation by HDL via SR-BI, Src kinases and Rac is also demonstrable. Paralleling the in vitro findings, carotid artery …
-
Mechanismen der Urocortin-II-induzierten Stimulation der NO-Produktion in isolierten Kaninchen-Ventrikelmyozyten
… Diese Wirkungen wurden durch Inhibitoren der Phosphatidylinositol 3-Kinase (PI3K), Wortmannin (0,3 µM) und LY294002 (10µM) nahezu vollständig aufgehoben. Konfokale Bildgebung der zellulären NO-Produktion und der fraktionellen Verkürzung zeigen einen Anstieg des [NO]i und der fraktionellen …
-
Regulation of Cell Migration by WNK1
… of cell motility by a serine/threonine protein kinase, WNK1 (With No lysine (K)1), so named because of the absence of a conserved lysine within the catalytic domain. Although WNK1 has been most thoroughly characterized for its role in controlling ion flux in the kidney, emerging evidence points …
-
Glycogen Synthase Kinase 3 Is Required For Optimal Akt Activation
<p>The phosphatidylinositol 3-kinase (PI3K) pathway, through its major effector node AKT, is critical for the promotion of cell growth, division, motility and apoptosis evasion. This signaling axis is therefore commonly targeted in the form of mutations and amplifications in a myriad of …
-
Klonierung der cDNA des Protein A Kinase-Adaptor-Proteins-2 und Untersuchungen zur Regulation seiner mRNA in humanen fötalen Osteoblasten
… die vollständige cDNA-Sequenz des Proteinkinase A-Ankerproteins-2 (AKAP-2, 7,5kB) ermittelt. Zu diesem neuen humanen Gen sind bis dato außer einem unvollständigem Datenbankeintrag noch keine experimentellen Daten zur cDNA, mRNA oder zum Protein veröffentlicht. Mittels Northernblot wurde …
-
Identifying Novel Functions of the WNK Pathway
… with no lysine [K] (WNK) pathway consists of WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and OSR1/SPAK substrates, cation chloride cotransporters. The pathway regulates ion transport across cell …
Page 1 of 4