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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 232 for “"phosphatidylinositol"”.
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Designing Compounds that Probe the Phosphatidylinositol 3-Kinase Signalosome
Phosphoinositide 3-kinases (PI3K) are major regulators of many cellular functions, and its hyperactivation is a major target for anticancer drug discovery. PI3Kα is the isoform most implicated in cancer, and this thesis is dedicated to investigating how specific protein-ligand interactions in the …
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Modulation of host phosphatidylinositol phosphates by salmonella effector protein SOPB
… SopE2 activates Cdc42 only. SopB is a known phosphatidylinositol phosphate phosphatase possessing both 4- and 5-phosphatase activities promoting membrane ruffling and invasion. The mechanisms through which SopB utilizes its phosphatase activities to mediate membrane ruffling and invasion are …
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Phosphatidylinositol 3-phosphate binding properties and autoinhibition mechanism of Phafin2
… Both the Phafin2 PH and FYVE domains bind phosphatidylinositol 3-phosphate [PtdIns(3)P], a phosphoinositide mainly found in endosomal and lysosomal membranes. Phafin2 acts as a PtdIns(3)P effector for endosomal cargo trafficking, macropinocytosis, apoptosis, and autophagy. The PtdIns(3)P …
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The Function of Phosphatidylinositol 4-Kinase III-Beta in Trypanosoma Brucei
Phosphatidylinositol 4-kinase phosphorylates phosphatidylinositol at the D4 position resulting in phosphatidylinositol 4-monophosphate. Subsequent phosphorylation events result in a group of molecules known as phosphoinositides. These molecules are important in signal transduction, endocytosis, …
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Effects of phosphatidylinositol on ApoA-I metabolism: Implications in HDL metabolism
… CHD. Naturally occurring phospholipids such as phosphatidylinositol (PI), have been shown to increase plasma apoA-I levels and HDL levels in animal models and human subjects; but the mechanism remains to be elucidated. Since in humans, HDL is primarily synthesized in the liver, the objective of …
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Regulatory role of phosphatidylinositol 4-phosphate 5-kinases in brain inflammation
Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], mainly produced by the type I phosphatidylinositol 4-phosphate 5-kinase (PIP5KI) family members, PIP5KIα, PIP5KIβ and PIP5KIγ, is an important regulator of diverse cellular processes at the cell surface, such as cell survival, cell proliferation, …
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Multiscale Simulations of Phosphatidylinositol Bisphosphate: Understanding Its Biological Role Through Physical Chemistry
… -1 at physiological pH, but some lipids such as phosphatidylinositol bisphosphate (PtdInsP2) bear a net charge of -4. The ability of these highly charged lipids to interact with monovalent and divalent cations affects their spatial organization and temporal distribution on the cytoplasmic side of …
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A screen for phosphatidylinositol 3,4-bisphosphate and other 3-phosphoinositide effector proteins
… and metabolism via their primary lipid product phosphatidylinositol 3,4,5- trisphosphate (PtdIns(3,4,5)P3) and a metabolite of this, phosphatidylinositol 3,4- bisphosphate (PtdIns(3,4)P2). Many effector proteins for PtdIns(3,4,5)P3 are well recognised but by contrast, few molecular targets for …
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Phosphatidylinositol 4-phosphate 5-kinase Involved in Neuroglial Toll-like Receptor Signaling
… studied. It was previously demonstrated that phosphatidylinositol 4,5-bisphosphate (PIP2), a membrane lipid produced mainly by the type I phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family members, was necessary for TLR4 signaling. However, details of the PIP5K-mediated PIP2 production …
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Functions of Phosphatidylinositol 4-Phosphate 5 Kinases in Actin Cytoskeletal Regulation During Phagocytosis
Phosphatidylinositol (4,5)-bisphosphate (PIP2) is a crucial signaling phosphoinositide at the plasma membrane (PM) which mediates a variety of biochemical activities and cellular functions. It is primarily synthesized by type I phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) through the …
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Differential Regulation of Phosphatidylinositol 4-Phosphate 5 Kinase Beta during Hypertonic and Oxidative Stress
… role in regulating cellular homeostasis. The phosphatidylinositol derivative, PI(4,5)P2 (PIP2)is an essential mediator of cellular processes such as signal transduction, membrane traffic, actin cytoskeleton, ion homeostasis, growth and apoptosis. Despite the importance of this signaling …
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Role Of Type Ii Phosphatidylinositol 4-Kinases In Endosomal Tubule Dynamics During Melanosome Biogenesis
… entirely known, but several studies suggest that phosphatidylinositol-4-phosphate (PtdIns4P) and the type II PtdIns-4-kinases, PI4KIIα and PI4KIIβ, may play a role. Moreover, PI4KIIα and PI4KIIβ interact respectively with AP-3 and AP-1, both of which control BLOC-1-dependent cargo sorting. We …
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EPIGENETIC REGULATION OF MICROGLIAL PHOSPHATIDYLINOSITOL 3-KINASE PATHWAY INVOLVED IN SYNAPTIC PLASTICITY IN RODENTS
… central nervous system (CNS). Microglia express phosphatidylinositol 3-kinase (PI3K), shown to play a significant role in synaptic plasticity in neurons. This study shows that the microglial PI3K/AKT pathway is epigenetically regulated through miRNA targeting by miR-21-5p and histone …
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The Ligand and Membrane-binding Behaviour of the Phosphatidylinositol Transfer Proteins (PITPa & PITPb)
Human Class I phosphatidylinositol transfer proteins (PITPs) exists in two forms: PITPα and PITPβ. PITPs are believed to be lipid transfer proteins based on their capacity to transfer either phosphatidylinositol (PI) or phosphatidylcholine (PC) between membrane compartments in vitro. In Drosophila, …
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Investigating the structure-function relationships of Plasmodium Haem Detoxification Protein and Phosphatidylinositol 4-kinase
… haemozoin formation in Plasmodium and (ii) Phosphatidylinositol-4- Kinase β (PI4Kβ) which plays an essential role in multiple stages of the parasite lifecycle and is a clinically validated drug target for malaria chemotherapy. Previous efforts to characterise HDP have been limited to …
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