Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"phosphatidylethanolamine (PE)"”.
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Structural effects of neutral lipids on the divalent cation-induced interactions of phosphatidylserine - containing bilayers
… structures might be modified by neutral lipid species. X-ray diffraction data from multilamellar systems suggest that phosphatidylcholine (PC) and diacylglycerol (DG) might be in the collapsed phase up to a concentration of -30 mole % and that above this concentration these neutral lipids may …
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Characterization of the lipid composition of washed and percoll gradient centrifuged epididymal mouse sperm.
… process during which the fluidity of the sperm membrane increases to prepare sperm for the acrosome reaction (AR) and subsequent sperm-egg binding. While cholesterol efflux may be partially responsible for this increase, modification of lipid components, such as remodeling of specific …
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Interactions of Inorganic Mercury and Inorganic Cadmium with Biomimetic and Complex Biological Membranes and their Influence on Membrane Packing and Size
… containing cationic and anionic lipids respectively. Hg2+ also imparts rigidity by acting as a catalyst in the vinyl ether hydrolysis of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) plasmalogens. Cd2+-induced rigidity of anionic membranes results in a stabilization of the gel …
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The Effect of Seven Carcinogens on Phosphatidylcholine and Phosphatidylethanolamine Metabolism in Larvae of the Indian-Meal Moth
<p>Alterations of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) metabolism were investigated in the larvae of Plodia interouncte11a (Indian-meal moth) receiving diets containing seven different carcinogense The fatty acid composition of PC and PE as well as the radioactive …
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Biochemical and Structural Characterization of the Atg8/LC3 Lipidation Pathway
… their covalent ligation to lipids, typically phosphatidylethanolamine (PE), in a process known as lipidation. Lipidation of Atg8 family proteins regulates numerous facets of the autophagy process, including regulating expansion of the phagophore membrane, recruiting selected cargoes for …
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The importance of long chain polyunsaturated fatty acids for fetal immune system maturation and function
… the first study to examine the lipid profile of phosphatidylethanolamine (PE) and phosphatidylcholine (PC) fractions of CBMC membranes from preterm and DNI neonates. The LCPUFA composition of CBMCs was dominated by arachidonic acid (AA, 20:4co6) in the PE (34%) and PC fractions (15%) in term …
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ATG8 Regulation and Function in Non-Canonical Autophagy
… autophagy, it is widely accepted that the lipid species conjugated to ATG8 proteins is phosphatidylethanolamine (PE). However, using mass spectrometry, this study shows for the first time in vivo that ATG8 proteins can become conjugated to both PE and phosphatidylserine (PS) upon stimulation of …
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Determination of the roles of the Trypanosoma brucei lipin homologue TbLpn
… triacylglycerol (TAG). TAG is then used to form phosphatidylethanolamine (PE) and phosphatidylcholine (PC), which are major lipids that constitute the membrane of T.b. In order to better understand how TbLpn functions, we checked if it was phosphorylated in vivo by protein methyl transferases …
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Metabolism of omega-3 fatty acids in carriers of apolipoprotein E epsilon 4
… such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) can decrease the risk of developing Alzheimer’s disease. However, the benefit of consuming omega-3 fatty acids is not seen in APOE4 carriers. Additionally, studies have demonstrated that brain can take-in fatty acids in the …
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Exploration of the biosynthesis of lanthipeptides
… pharmaceutical investigations. A major class of peptide-based natural products are ribosomally synthesized and post-translationally modified (RiPPs). Lanthipeptides, which possess (methyl)lanthionine structures, are a class of intensively studied RiPPs. Based on the biosynthesis enzymes that …
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Biochemical studies of the tear film in humans and rabbits
… longer inter-blink time compared to humans, perhaps due to their very stable tear film. The reason for this, however, has never been studied at a detailed biochemical level. This research project therefore sets out to examine the tear film biochemistry and molecular interactions in humans and …
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Regulation of phosphatidylcholine biosynthesis in apium graveolens
… sterol biosynthesis inhibitor, paclobutrazol, suspension cultures of Apium graveolens (celery) accumulate substantial amounts of I 4a-methylsterols, at the expense of 4-demethylsterols. These changes have been correlated with reduced synthesis of phosphatidylcholine (PC) via the CDP-base pathway …
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Analysis of gamma secretase regulation by phosphatidylethanolamine using mammalian and Drosophila melanogaster in vitro and in vivo model systems
A?-amyloid peptide (A?), that plays a central role in the pathogenesis of Alzheimer’s disease is derived by sequential proteolytic processing from the amyloid precursor protein (APP) by ?- and ?-secretase. APP is additionally processed through a non-amyloidogenic pathway by ?-secretase. Recent work …
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Molecular analysis of vesicle biogenesis during autophagy
… has been proposed to cycle between the PAS and a peripheral pool that may serve as a membrane source. In S. cerevisiae this pool has been described to colocalize in part with mitochondria. This was questioned in mammalian cells where this peripheral pool colocalizes with the trans Golgi network …
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Targeting Nanoparticles to Tumor Vasculature
… tumor vessels represents an indirect therapeutic approach in oncology by shifting the treatment away from the tumor cells themselves. Endothelial cells are generally considered genetically stable and do not use escape mechanisms against chemotherapeutic agents as frequently as tumor cells …
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Innovations in detecting food fraud using mass spectrometric platforms and chemometric modelling
… and intentional substitution, addition, tampering or misrepresentation of food, food ingredients and food packaging for an economic gain. It is in many cases close to impossible for consumers and players in the food industry to identify. The aim of this thesis was to study whether mass …
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Regulators of autophagy in Leishmania major
… under starvation conditions, suggestive of a specific role for ATG8A in starvation induced autophagy. Although ATG8 and ATG8A both participate in a response to starvation, they differed in their sensitivity to the PI(3) kinase inhibitor wortmannin, responded differently to the presence of …
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Structural studies of membrane-associated complexes by solid-state NMR
… utilizes solid-state nuclear magnetic resonance spectroscopy to investigate the structure of calcium-phosphatidylserine (PS) complexes that regulate blood coagulation, and to understand how interactions of the antifungal drug amphotericin B with ergosterol are related to its toxicity. The …
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Investigations into the Lipid Transport Mechanisms and Energetics of Bacterial ATP-Binding Cassette (ABC) Transporters MsbA and LmrA
… is based on a 2Na<sup>+</sup>/(1H<sup>+</sup>-1HEPES<sup>+</sup>-1Cl−)<sup>+</sup> exchange reaction. It also shows a Na<sup>+</sup>/ethidium<sup>+</sup> antiport reaction that can be driven by the sodium-motive force, which when directed inwardly in cells gives rise to enhanced ethidium efflux, …
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Host cell death in Legionella pneumophila pathogenesis and immunity
… is a phospholipase A2 that hydrolyzes the phosphatidylethanolamine (PE) and phosphatidylcholine (PC) on the mitochondrial membrane in a manner that appears to require host cofactor(s). The lipase activity is essential to its ability to activate caspase-3 via the production of free fatty …
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