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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 128 for “"phosphatidylcholine"”.
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Solubilisation properties of phosphatidylcholine
… and related sugars by thoroughly-purified phosphatidylcholine (lecithin) in benzene solution has been studied. The extent of solubilisation of the sugar has been found to depend on the concentration of lecithin, the structure of the sugar and the presence of cholesterol as a co-solute. The …
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Regulation of phosphatidylcholine biosynthesis in apium graveolens
… have been correlated with reduced synthesis of phosphatidylcholine (PC) via the CDP-base pathway (Roiph & Goad, 1991). It was subsequently proposed that changes in the membrane sterol composition of plant cells may regulate the activity of CTP: cholinephosphate cytidylyltransferase (CT), the …
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Hormonal regulation of phosphatidylcholine metabolism in Apium graveolens
… acid led to the hypothesis that two pools of phosphatidylcholine exist within the plant cell; one capable of producing signals involved in cell proliferation and the other capable of releasing signaling molecules which facilitate cell differentiation. It was the aim of this study to extend the …
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Interaction of Human Apolipoprotein a-I With Dipalmitoyl Phosphatidylcholine
Dipalmitoylphosphatidylcholine (DPPC) bilayer lipid will react with human apolipoprotein A-I (apo A-I) to form lipid-protein micellar complexes. The reactivity of the lipid bilayer is dependent upon the physical state of the vesicle. Large vesicles with essentially planar bilayers do not form …
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Spontaneous Phosphatidylcholine Exchange Between Vesicles and Micellar Lipid-Apolipoprotein Complexes
The spontaneous exchange of phosphatidylcholine (PC) between model lipoproteins and small unilamellar vesicles was investigated. The model lipoproteins were recombinants of bovine apolipoprotein A-I, egg PC, and cholesterol produced by cholate dialysis. Vesicles contained egg PC and cholesterol in …
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Apolipoprotein E Activation and Phosphatidylcholine Substrate Requirements of Lecithin Cholesterol Acyl Transferase
… apo E into discoidal complexes of egg phosphatidylcholine (egg-PC) and cholesterol by the cholate dialysis method. These complexes were systematically compared to apo A-I complexes synthesized under the same reaction conditions. Apo E was found to be 18% as effective as apo A-I in …
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The Impact of Dietary Fat and Phosphatidylcholine on Increased Trimethylamine-N-oxide Levels
… to dietary TMA containing substrates such as phosphatidylcholine (PC), choline, and L-carnitine. A high-fat diet is an environmental risk factor that may increase TMAO production. However, it isn’t clear if the high dietary intake of TMA is sufficient to promote increased plasma TMAO or if a …
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Association of dietary and phosphatidylcholine supplement intake with cardio-metabolic biomarkers among normo- and hyperlipidaemic individuals
… with the development of cardiovascular disease. Phosphatidylcholine is a component of cellular membranes and plays a vital role in lipoprotein metabolism. Many studies have investigated the effects of phosphatidylcholine on lipid profiles; however, results have been inconsistent, therefore the …
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The Effect of Seven Carcinogens on Phosphatidylcholine and Phosphatidylethanolamine Metabolism in Larvae of the Indian-Meal Moth
<p>Alterations of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) metabolism were investigated in the larvae of Plodia interouncte11a (Indian-meal moth) receiving diets containing seven different carcinogense The fatty acid composition of PC and PE as well as the radioactive …
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The Saccharomyces cerevisiae phosphatidylinositol/phosphatidylcholine transfer protein functions as a negative feedback regulator of the CDP-choline pathway
… cerevisiae phosphatidylinositol (PI)/phosphatidylcholine (PC) transfer protein (SEC14p) is required for Golgi function in vivo. Mutations that specifically result in the inactivation of the CDP-choline pathway for PC biosynthesis bypass the requirement for SEC14p. The in vivo …
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Effect of Structure and Composition of Reconstituted High Density Lipoproteins on Phosphatidylcholine Transfer by Human Plasma Phospholipid Transfer Protein
… used to study the effect of HDL substrates on phosphatidylcholine (PC) transfer by human plasma phospholipid transfer protein (PLTP) by changing the composition and size of rHDL. Sonicated egg-PC:cholesterol vesicles containing radiolabelled dipalmitoyl-PC ($\sp $C-DPPC) were used as donors and …
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Pct1 regulates phosphatidylcholine synthesis in response to changes in surface curvature elastic stress sensed on the inner nuclear membrane
… found in membranes of living organisms, phosphatidylcholine (PC) is the most abundant. The rate-limiting step of the predominant pathway for PC synthesis in eukaryotic cells is catalysed by the enzyme, CTP: phosphocholine cytidylyltransferase α (CCTα or PCYT1A). CCTα has a critical role …
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Synthetic Micellar Complexes of Apolipoprotein a-I With Lipids as Substrates for Human Lecithin Cholesterol Acyltransferase
… cholate. The lipid mixtures included dimyristoyl phosphatidylcholine (DMPC), dipalmitoyl phosphatidylcholine (DPPC), and egg phosphatidylcholine (egg-PC). The formation of complexes was examined at increasing cholesterol contents with DPPC, and at 20 mole % cholesterol contents for DMPC, DPPC, and …
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Lateral organization and dynamics of phospholipids in membrane
… observed between gramicidin and dansyl-labeled phosphatidylcholine, phosphatidylethanolamine, or phosphatidic acid. However, another integral membrane protein, D-$\beta$-hydroxybutyrate dehydrogenase (BDH), reorganized the phospholipids in the bilayer into a nonrandom distribution. Although the …
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Studies on the induction of the hepatic microsomal mixed function oxidase system
… microsomal protein, cytochrome P-450, and phosphatidylcholine in all dietary groups; however, in all groups the increase in P-450 was greater than for phosphatidylcholine. Protein deficiency (Groups 1 vs. 2) decreased P-450 and microsomal protein but had no effect on phosphatidylcholine …
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Synthesis and Evaluation of Trans-bilayer Cross Linking Phospholipids Based on Click (Azide-Alkyne) Chemistry
This thesis describes the synthesis of two phosphatidylcholine (PC) derivatives that are capable of coupling with each other from the alkyl chain through click reaction to form bola-PC. Successful coupling of monomeric phosphatidylcholine derivatives would lead to synthesis of corresponding …
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Identification and quantification of lipid metabolites in cotton fibers: Reconciliation with metabolic pathway predictions from DNA databases.
… abundant fatty acids present in fiber cells. Phosphatidylcholine was the predominant lipid class in fiber cells, while phosphatidylethanolamine, phosphatidylinositol and digalactosyldiacylglycerol were also prevalent. An unusually high amount of phosphatidic acid was observed in frozen cotton …
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Secondary ion mass spectrometry as a tool to evaluate chemical composition within model and cellular membranes
… supported lipid membranes containing saturated phosphatidylcholine lipid species was studied. While the NanoSIMS 50 afforded unprecedented lateral resolution on the chemical distribution of these model membranes, it was achieved at the cost of employing stable-isotope labels for component …
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Aspects Of Pulmonary Surfactant Metabolism
… at the air liquid interface of the alveolus. Phosphatidylcholine represents the principal component of surfactant (70% by weight), other lipids account for 20% of surfactant and the remaining 10% is protein. Four surfactant-associated proteins have been identified, surfactant associated …
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