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Showing 1 to 20 of 33 for “"phosphate groups"”.
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Investigation of the action of phosphatase of regenerating liver on PTEN using murine models
The addition and removal of phosphate groups is a key regulatory mechanism for many cellular processes. The balance between phosphorylation and dephosphorylation is delicate and must be maintained in order for proper cell functions to be carried out. Protein kinases and phosphatases are the keepers …
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Phosphoproteins of the Cell Nucleus: Metabolism and Characterization
… calf thymus nuclei employing P<sup>32</sup>-orthophosphate as a tracer. These isolated nuclei incorporate this isotope into nuclear proteins, which yield phosphoserine and phosphothreonine on hydrolysis. Protein phosphorylation is energy dependent, and occurs after the polypeptide chain has been …
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Toward the Synthesis of Nuclease Models.
… models that combine the ability to recognize phosphate groups and/or nitrogen bases of DNA together with the ability to catalyze phosphodiester hydrolysis. These models were designed to achieve optimum interaction between the recognition and the catalytic functionalities. Towards this goal, we …
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Dispersionen für den Korrosionsschutz von Aluminium
… means of a two-step emulsion polymerisation with phosphate substituted monomer we obtain polymeric nano-particles with phosphate groups on the surface. In a first step cross-linked butyl acrylate/styrene particles were formed. In a second step a mixture of functionalised acrylate and butyl …
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ENZYME-LIKE DNA CATALYST DESIGN
… turnover. The work further demonstrates that DNA phosphate groups can actively control stereoselective ion-pairing catalysis by organizing cationic intermediates near catalytic sites. Phosphorothioate substitution experiments reveal that specific local phosphates govern stereocontrol, while distal …
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Effects of phytic acid sorption on iron polymerization and at the ferrihydrite-water interface
… were proposed, it is not clear how multi phosphate groups of phytic acid contribute to the surface complexation and/or precipitation processes. In this study, sorption behavior of phytic acid in ferrihydrite was examined using experimental geochemistry, solution 31P nuclear magnetic …
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Synthesis and Characterization of Nucleobase-Containing Polyelectrolytes for Gene Delivery
… Polyelectrolytes containing hydrogen bonding groups are expected to exhibit properties of both classes of supramolecular interactions. A series of adenine- and thyminecontaining PDMAEMA and tert-butyl acrylate copolymers were synthesized to investigate the effect of incorporating hydrogen …
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Direct conversion of chemical energy to mechanical work using a phosphate charged protein
… one another by breaking the "energy-rich" pyrophosphate bond of ATP. The energy from ATP hydrolysis is used for mechanical motion and the energy lost during this process is used to heat our body. In biology, the sliding filament system is taken as a fairly effective model. For engineering …
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Site-Specific Incorporation of Biochemical and Biophysical Probes into Proteins Using Expressed Protein Ligation
… to site-specifically insert fluorophores and phosphate groups into proteins. The chemical manipulation of proteins by EPL will be an important tool as researchers strive to characterize the proteomes of organisms.</p>
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Synthesis, crystallography and biological activity of myo-inositol phosphates
The antioxidant property of myo-inositol hexakisphosphate is important in the prevention of hydroxyl radical formation which may allow it to act as a 'safe' carrier of iron within the cell. Here, the hypothesis that the recently discovered natural product, myo-inositol 1,2,3-trisphosphate …
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Supramolecular templating of mesoporous zirconia-based nanocomposite catalysts
… catalysis. The three systems of interest, (i) phosphated zirconia, (ii) zirconia-silica, and (iii) tungstated zirconia, represent mesoporous materials of different acidic strengths and thermal stabilities. The synthesis of mesoporous phosphated zirconia was achieved through the use of …
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The role of molybdenum in the formate dehydrogenase of methanobacterium formicicum
… Neurospora crassa mutant nit-1 and possessed two phosphate groups. Incubation of oxidized formate dehydrogenase with cyanide resulted in an irreversible loss of enzyme activity which could not be restored by treatment with sulfide. Equimolar amounts of thiocyanate were released from …
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Putting the Needle to the Haystack: Submolecular Structure Elucidation with Atomic Force Microscopy in Ultra High Vacuum
… in such a way to bind to two neighboring phosphate groups of the DNA backbone. This effect aims at blocking polymerase processes in order to stop tumor growth in chemotherapy. While this effect has been shown with several methods, their direct visual confirmation of this binding mode was …
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Isolation and Characterization of Soybean Genes Involved in Phytic Acid Metabolism: Phytase and 1-L-myo-Inositol-1-Phosphate Synthase
… = 60 mM) and was capable of removing of all six phosphate groups from phytate. The pH and temperature optima for soybean phytase activity were 4.5 and 58*C, respectively. The N-terminus and four internal peptides from the purified soybean phytase were sequenced by Edman degradation. The amino …
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O-H activation in phosphates: oxidative addition to an iridium(I) center and reactivity of the resulting iridium(III) species
… importance to [Ir(1,5-COD)(PMe₃)₃]Cl. Since phosphates are an important functional group in biochemistry, the purpose of this research was to study the possible binding modes of the phosphate group to the iridium center and then to react biologically occurring phosphates with …
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Force Field Parameters and Atomistic Surface Models forHydroxyapatite and Analysis of Biomolecular Adsorption at Aqueous Interfaces
… binding is mediated by interactions of ammonium groups on the K side chain and at the N terminus with superficial monohydrogen phosphate groups in agreement with NMR studies, as well as by coordination of superficial calcium ions by the C terminus. Furthermore, three bisphosphonate molecules used …
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The Role of CDC25A in Ultraviolet-induced Nonmelanoma Skin Tumorigenesis
… phosphatase that removes inhibitory phosphate groups from cyclin-dependent kinases, allowing cell cycle progression. Activation of cell cycle checkpoints following DNA damage can result in degradation of CDC25A, leading to cell cycle arrest. Consistent with its role in cell cycle …
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Absorption of Chromium Across the Rat Small Intestine
… chromium to the intestinal tissue, possibly to phosphate groups, suggests that the intestinal barrier acts as a controlling factor for the amount of chromium entering the body pool, and also predicts other conditions that might affect the absorption of chromium.
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Structure and regulatory mechanism of human uncoupling protein 1
… of nucleotide binding. The negatively charged phosphate groups of the nucleotide are positioned close to the negatively charged residues of the matrix gate, requiring proton-mediated bonds to prevent the electrostatic repulsion that occurs at higher pH levels. UCP1 has retained all of the key …
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Action of Tyrosyl DNA Phosphodiesterase on 3'-Phosphoglycolate Terminated DNA Strand Breaks
… are terminated by 3'-PG (PO4CH2COOˉ) or 3'-phosphate groups formed as a result of fragmentation of deoxyribose. To study the nature of repair of these 3'-blocked breaks, we constructed substrates mimicking free-radical induced DSBs. Human and yeast tyrosyl DNA-phosphodiesterase (Tdpl) …
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