Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"pheochromocytoma"”.
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Pheochromocytoma-induced cardiomyopathy : a model of synergistic effects of multifactorial tumor secretions
… disease observed by catecholamine-secreting pheochromocytoma cells. Pheochromocytomas are widely believed to induce cardiomyopathy via hypersecretion of catecholamines including norepinephrine (NE). NE can have direct cardiomyocyte toxicity and can stimulate myocardial remodeling secondary to …
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Regulation of n-3 PUFA biosynthesis in proliferating and differentiated PC12 pheochromocytoma cells
… in proliferating and NGF-differentiated PC12 pheochromocytoma cells deficient in n-3 docosahexaenoic acid (DHA, 22:6n- 3) was studied. A dose- and time dependent increase in eicosapentaenoic acid (EPA, 20:5n-3), docosapentaenoic acid (DPA, 22:5n-3) and DHA in phosphatidylethanolamine (EPG) and …
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Minimally invasive adrenalectomy for pheochromocytoma: a systematic review of clinical outcomes compared with open surgery
Το φαιοχρωμοκύττωμα είναι σπάνιος νευροενδοκρινικός όγκος του μυελού των επινεφριδίων, με ιδιαίτερη κλινική σημασία λόγω της παραγωγής κατεχολαμινών και του κινδύνου σοβαρής περιεγχειρητικής αιμοδυναμικής αστάθειας. Η χειρουργική επέμβαση αποτελεί τη μόνη οριστική θεραπεία. Ανέκαθεν, η ανοικτή …
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Temporal evolution of intracellular signaling and gene expression following patterns of membrane depolarization in the pheochromocytoma cell line, PC 12
… of membrane depolarization on undifferentiated pheochromocytoma (PC 12) cells. In response to chronic depolarization, cytoplasmic free Ca2+ ([Ca2+]i) levels increased transiently, then decreased to intermediate levels that were maintained for more than 90 minutes. Short pulses of depolarization, …
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60 Hz magnetic field exposure inhibits protein Kinase C dependent induction of Neuropeptide Y mRNA in PC-12 cells
… induced production of NPY mRNA in the rat pheochromocytoma, PC-12 cell line.
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60 Hz magnetic field exposure inhibits protein Kinase C dependent induction of Neuropeptide Y mRNA in PC-12 cells
… induced production of NPY mRNA in the rat pheochromocytoma, PC-12 cell line.
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… sequence 21 (TIS21) is the mouse homolog of rat pheochromocytoma cell 3 (PC3) and human B-cell translocation gene 2 (BTG2). TIS21 regulates cell cycle progression and proneural genes expression by acting as a transcription coregulator that enhances or inhibits the activity of transcription …
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Mechanism of Action of Antipsychotics, Haloperidol and Olanzapine in vitro
… mechanisms of drug-induced cell death in PC-12 pheochromocytoma cells exposed to HP or Olz. At low dose (50 µM), HP was more cytotoxic than Olz. At high concentrations (150 mM) each of these antipsychotic drugs caused a significant increase in cell death that was readily detectable by all the …
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Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells
… of nitric oxide synthase (NOS), in rat pheochromocytoma PC12 cells. NGF/TNFa-promoted iNOS can be toxic in PC12 cells. Using PC12 cell mutants lacking the low affinity p75NTR receptor, we also demonstrate that this receptor is required to mediate iNOS expression, likely acting through …
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Evaluation of Prototype Cell Delivery Catheters Using Agarose Gel and Cell Culture Experiments
… cell culture experiments. We initially delivered pheochromocytoma (PC 12) cells through a 25-gauge syringe needle to optimize cell growth. We observed in the agarose gel experiments that when the inner catheter was filled and then inserted with the outer catheter into gel, no air bubble or …
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Physical mapping of a 2-Mb region centered at D10S94, a locus very tightly linked to the multiple endocrine neoplasia type 2 gene(s)
… by medullary thyroid carcinoma (MTC), pheochromocytoma and parathyroid hyperplasia. The related syndrome MEN 2B comprises MTC, pheochromocytoma and mucosalneuromas. Genes responsible for these cancers map to the pericentromericregion of chromosome 10, as do loci responsible for …
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Von Hippel-Lindau Syndrome: Characterization of a Potentially Novel VEGF-A Isoform and Elucidation of Molecular and Vascular Mechanisms of Observed Phenotypic Changes
… including neurological hemangioblastoma (HB), pheochromocytoma (PCC), pancreatic neuroendocrine tumors (PNET), pancreatic and renal cysts, and clear cell renal cell carcinoma (ccRCC). The disease process follows Knudson's two-hit model, requiring spontaneous loss or mutation of a normal VHL …
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COMBINATORIAL DEVELOPMENT OF NANOSTRUCTURED MATERIAL LIBRARIES FOR THE STUDY OF CELL SUBSTRATE INTERACTION
… angle measurements. PC12 cells derived from a Pheochromocytoma of the rat adrenal medulla were cultured on five different morphologies in presence of nerve growth factor (NGF) and the results suggest that the increasing roughness not only diminishes cellular attachment but also reduces the …
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A Cancer-Specific Study On The Differentially Expressed Protein-Protein Interactions of Fumarate Hydratase
… cell carcinoma, skin and uterine leiomyomas, pheochromocytoma, and paraganglioma. However, we aim to construct an interaction network of significant genes related to the FH gene under conditions of FH deficiency in the Kreb Cycle. Creating an interactive network that illustrates the …
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Identification Of Neuroblastoma And Its Prognostic Markers Using Raman Spectroscopy
… peripheral nerve sheath tumor, and pheochromocytoma. It is commonly situated on the adrenal gland. It displays similar histology to other small round blue cell tumors, including non-Hodgkin lymphoma, rhabdomyosarcoma, and Ewing sarcoma. One method of judging neuroblastoma …
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Zinc ion homeostasis in cellular physiology and experimental models of traumatic brain injury
… in undifferentiated and differentiated rat pheochromocytoma (PC12) cells and in rat glioma (C6) cells. When PC12 cells proliferate, [Zn2+]i undergoes precisely controlled fluctuations with two peaks within one cell cycle. These results demonstrate that the already established requirement for …
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Effects of nerve growth factor on TGF-Beta,Smad signal transduction in PC12 cells
… signaling pathways is characterized in rat pheochromocytoma cells (PC12) which are frequently used as a model system for neuronal differentiation. PC12 cells were found to be unresponsive to TGF-ß due to limiting levels of TßRII. However, stimulation with NGF results in initiation of …
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Evaluation of inhibitors of histone deacetylases as potential neurotrophic agents
… (NS-1) cells, a subclone of PC-12 (rat pheochromocytoma) cells. </p> <p>The HDAC inhibitors were tested alone and in combination with nerve growth factor (NGF). An in vitro method has been standardized that measures neurite outgrowth along with cytotoxicity of test compounds in a single …
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Microglial Phagocytosis of Bacteria and Synapses
… as did non-activated microglia, astrocytes and pheochromocytoma under specific experimental conditions. Exogenous UDP induced microglial phagocytosis of the bacteria in a time-sensitive manner, and this effect was inhibitable by blocking P2Y6R, suggesting that P2Y6R signalling regulates …
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Characterization of the Beta-2 Adrenergic Receptor Mechanism in Bovine Neutrophils, and Some Effects of Inflammatory Stimuli on its Function
… asthma, cystic fibrosis, atopic dermatitis, pheochromocytoma, myasthenia gravis, hypertension, and sepsis have all been linked to decreased beta1- / beta2-adrenergic receptor density (depending on the cell type) and / or uncoupling of the respective receptor from its effector enzyme, adenylyl …
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