Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"phenyl saligenin phosphate"”.
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Spinal cord gene expression changes in the chicken (Gallus gallus) model of phenyl saligenin phosphate induced delayed neurotoxicity
… for OPIDN induction. It was hypothesized that phenyl saligenin phosphate (PSP), a neuropathic OP ester that essentially irreversibly inhibits NTE as it undergoes the chemical aging process, results in changes in spinal cord gene expression that do not occur with phenylmethylsulfonyl fluoride …
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Photochemical harpoons: covalent labels for multi-protein complexes
… the biomolecular targets of the known organophosphate toxin, phenyl saligenin phosphate (PSP), and the cardioprotective agent diazoxide. PSP is an organophosphate toxin that irreversibly inhibits hydrolase enzymes such as trypsin and chymotrypsin along with the common organophosphate target …
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Cardiovascular components of organophosphorus-induced delayed neuropathy
… of a single 2.5 mg/kg intramuscular injection of phenyl saligenin phosphate (PSP) into the breast muscle. Parameters were measured at 1, 3, 7, and 20 days post treatment. All hens developed clinical signs of delayed neuropathy by day 10 and these signs were maximal by day 20. Alterations of …
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Neuropathologic Effects of Phenylmethylsulfonyl Fluoride (PMSF)-Induced Promotion and Protection inn Organophosphorus Ester-Induced Delayed Neuropathy(Opidn) in Hens
The serine/cysteine protease inhibitor phenylmethylsulfonyl fluoride (PMSF) has been used both to promote and to protect against neuropathic events of organophosphorus-induced delayed neuropathy (OPIDN) in hens (Lotti et al., 1991; Veronesi et al., 1985; Pope and Padilla, 1990; Pope et al., 1993). …
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Involvement of calcium in organophosphorus-induced delayed neuropathy: a functional morphological, and biochemical study
… nifedipine, and verapamil, in the presence of phenyl saligenin phosphate, an active neurotoxicant. Attenuation of OPIDN by these compounds was revealed by clinical assessment, by changes in nerve excitability denoted by strength-duration relationships in response to electrical stimulation, by …
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Effects of organophosphate esters on blood vessels: a physiological, pharmacological, and histological assessment of involvement in organophosphorus-induced delayed neuropathy (OPIDN)
… of the cardiovascular system. to organophosphate-induced delayed neuropathy (OPIDN) was examined using in situ and in vitro models for demonstration of response to vasoactive agents (e.g., the cholinergic agonist, acetylcholine; the α1 agonist, phenylephrine; and the β2 agonist, …
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Effects of organophosphates on neural and purified liver tissue transglutaminase
… and it has been reported that certain organophosphates are able to inhibit this process, and the organophosphate phenyl saligenin compound also disrupts TGase 2 activity. It has also been shown that the organophosphates chlorpyrifos (CPF) and chlorpyrifos oxon (CPFO), which cause …
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The Molecular Mechanisms of Organophosphorus Compound-induced Cytotoxicity
… (DFP), paraoxon, parathion, phenyl saligenin phosphate (PSP), tri-ortho-tolyl phosphate (TOTP), and triphenyl phosphite (TPPi); 1uM - 1mM). These studies revealed that OP compounds altered the cell cycle phase, decreased the amount of intracellular f-actin, altered the …
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Biochemical effects of organophosphorous compounds on cultured rat and human cardiomyocyte-like cells
… study aimed to investigate the effects of phenyl saligenin phosphate (PSP), two organophosphorothioate insecticides (diazinon and chlorpyrifos), and their acutely toxic metabolites (diazoxon and chlorpyrifos oxon) on rat H9c2 and human cardiomyocyte-like cells. The rat embryonic H9c2 …