Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"phenotypic response"”.
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Phenotypic response to selection for protein in maize kernels
… selection in maize, the genetic basis for that response is largely unknown. The proteins that responded most to selection were the alpha-zeins, a class of the abundant seed storage proteins that are lacking in several essential amino acids. Thus, efforts to increase the nutritional quality of …
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Study of phenotypic and gene expression response to bacterial challenge
… (BCG)-induced inflammation, focus is placed upon phenotypic and gene-expression responses to the original challenge. Studies of the phenotypic response to BCG involves several behavior indicators, categorized as representing an initial period of sickness response, and a set of depression-like …
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Morphological study of Schizaea Pectinata (L.) Sw. (Schizaeaceae)
… in Schizaea pectinata could be linked to a phenotypic response to environmental differences between the two regions.
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Artemisinin-Based Combination Therapy (ACTs) Drug Resistance Trends in <em>Plasmodium falciparum</em> Isolates in Southeast Asia
… we conducted a blinded study to elucidate the phenotypic response of artemisinin derivatives of parasites derived from patient blood samples from Cambodia and Thailand. Blood samples containing Plasmodium falciparum were cultured and then assayed using SYBR green as an indicator to obtain drug …
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Dissecting the molecular mechanisms of therapeutic resistance in cancer
… or may be acquired after an initial clinical response to the therapy. Several mechanisms of drug resistance have been described in cancer, including alterations in the drug transport and metabolism process, mutations in drug-target, activation of bypass signaling pathways, inhibition of …
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New Methods of DNA Assembly, Gene Regulation with a Synthetic sRNA, and Cyanobacterium Phenotype Monitoring with Raman Spectroscopy
… sodium chloride and magnesium sulfate) on the phenotypic response of the cyanobacterium Synechocystis sp. PCC6803. The RametrixTM LITE Toolbox for MATLAB® enabled processing of Raman spectra and application of principal component analysis (PCA) and discriminant analysis of principal components …
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Coordinated regulation of the flagellar, Salmonella pathogenicity island 1, and the type I fimbriae gene networks in Salmonella typhimurium
… that process the information leading to a phenotypic response from the cell. Using the food-borne pathogen, Salmonella, as a model organism, we try to investigate how cells encode strategies in networks to optimally control cellular behavior. Salmonella, on ingestion with contaminated food, …
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Predictors Of Interindividual Differences In Vulnerability To Neurobehavioral Consequences Of Chronic Partial Sleep Restriction
Interindividual differences in neurobehavioral response to sleep loss are ubiquitous and unexplained. Numerous factors have been examined as potential predictors of phenotypic response to sleep loss but none have yielded a comprehensive view of the phenomenon. This dissertation examines the impact …
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Environmental Variability and Phenotypic Flexibility in Plants (Illinois)
… will possess a greater ability to respond phenotypically to this variability than genotypes within species or populations that have evolved in habitats with less environmental variability. The phenotypic response quantified in this thesis is phenotypic flexibility, the growth advantage …
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Single-cell differential splicing of Alzheimer’s Disease in 1.9 million cells across 416 individuals
… (AD) is a polygenic disease with variable phenotypic response among patients. While single-cell differential expression data can provide important information regarding the disease’s pathology, it only captures steady-state cell behavior. By contrast, RNA velocity analysis allows inference …
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A Context-Forward In Vivo Functional Genomics Platform For Target Discovery and Establishing Vulnerability Context In Pancreatic Cancer
… a more classical profile, coinciding with phenotypic response. These findings highlight this integrative network-anchored approach as a novel methodology for informing on gene dependency context in PDAC.</p>
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Investigation of cellular microenvironments and heterogeneity with biodynamic imaging
… count) and do not capture the dynamics of tissue response.</p> <p>Biodynamic imaging (BDI) is a 3D tomographic imaging and assay technique that uses the dynamics of scattered coherent light, or speckle, to measure dynamic response of tissue to perturbations. Dynamic measurements allow BDI to not …
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Environmental change impacts on shell formation in the muricid Nucella lapillus
… So far, existing knowledge about organism responses mainly stems from short to medium term laboratory experiments of single species or over- simplified communities. Although these studies have provided important insights, results may not translate to organism responses in a complex natural …
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Molecular and Physiological Aspects of Arbuscular Mycorrhizal Symbiosis with near-Isogenic White Clover: A Gene Expression Study
… functioning. In order to relate plant phenotype responses specifically to changes in phosphorus availability, and ultimately to gene expression, a nutrient flowing culture system was developed in which nutrient application was constant and could be controlled. The only consistent phenotypic …
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Characterizing bacterial antibiotic resistance, prevalence, and persistence in the Marine Environment
… cultures from Cape Cod, MA beaches to assess the phenotypic response to antibiotic resistance. I show that 73% of Vibrio-like bacteria and 95% of heterotrophic bacteria (both groups operationally defined) are resistant to at least one antibiotic. These results indicate that antibiotic resistance …
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Evolution of energy storage traits in symbiotic rhizobia
… first chapter assesses the extent of heritable phenotypic variation within natural rhizobia populations interacting with soybean (Glycine max) and partridge pea (Chamaecrista fasciculata) and evaluates implications for fitness in the free-living stage after rhizobia are released from nodules. …
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Improved In Silico Methods for Target Deconvolution in Phenotypic Screens
… leading to attrition in clinical trials. Phenotypic screening has hence undergone a renaissance in both academia and in the pharmaceutical industry, partly due to this reason. One key shortcoming of this paradigm shift is that the protein targets modulated need to be elucidated …
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Infectious disease as a cause and consequence of phenotypic responses to challenge in a songbird species
… and biotic conditions of their environment. Phenotypic shifts in response to one challenge can have cascading effects on other organismal systems, with downstream implications for individual fitness. Infectious disease presents a significant ecological challenge for most organisms on earth. …
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Effect of Population Sources and Species Pools on Community Phylogenetic and Functional Diversity During Restoration
… study showed the importance of considering the phenotypic response of subordinate species to intraspecific trait variability of dominant species and species coexistence in community ecology. In addition, using local ecotype could increase form functional and phylogenetic diversity of restored …
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Modelling the interactions of Salmonellae with the human host using stem cell-derived intestinal organoids and macrophages
… Typhi and the host mucosa and resultant immune response. However, in recent years, a new approach to studying pathogen-gut epithelial interactions has been developed; known as “organoids” or human intestinal organoid systems (iHO). These can be produced from human induced pluripotent stem cells …
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