Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"phenotypic heterogeneity"”.
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Phenotypic heterogeneity and evolutionary games in microbial populations
… of the last decade is the surprising degree of phenotypic variability between individual cells in clonal microbial populations, even in identical environments. While some variation is an inevitable consequence of low numbers of regulatory molecules in cells, the magnitude of the variability is …
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Phenotypic heterogeneity in high-grade serous ovarian cancer: evidence for a stochastic model of proliferation
… between cell clusters corresponding to observed phenotypic subpopulations. This provides a basis for future work into targeting the resistant subpopulation. In conclusion, this work refutes the proposed cancer stem cell model in HGSOC and presents evidence of stochastic division and …
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The role of physical interactions in shaping the genetic diversity of spatially expanding phage and bacterial populations
… microbial populations can display immense phenotypic heterogeneity leading to division of labour and seemingly cooperative behaviour. The effect of such interactions on the evolution of microbial populations, particularly those that are expanding in space, remains an open question. I …
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Modelli murini transgenici di malattie da prioni per lo studio del ruolo fisiopatologico della proteina prionica.
… in the PrP gene. The most clear example of the phenotypic heterogeneity determined by the Met/Val polymorphism is represented by fatal familial insomnia (FFI) and Creutzfeldt-Jakob disease (CJD178), two clinically and neuropathologically distinct diseases linked to the D178N mutation in the gene …
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Retinal function in deaf-blind syndromes
… to some extent, even in the early teens. Phenotypic heterogeneity in Usher syndrome was established both in children and adults, including three families with siblings. Among the adults the phenotypic heterogeneity could be demonstrated both in siblings with the same genotype and between …
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Population dynamics of bacterial persistence
… adapt to the regularly fluctuating environments. Phenotypic heterogeneity is one such strategy, where an isogenic population splits into subpopulations that respond differently under identical environments. Bacterial persistence is a prime example of such phenotypic heterogeneity, whereby a …
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Application of the single cell genomics in deciphering tumor heterogeneity and its role in tumor progression and drug resistance
… cell genomic method is crucial for deciphering phenotypic heterogeneity. Here, we profiled single cell transcriptomes from genetically engineered mouse lung tumors at seven stages spanning tumor progression from atypical adenomatous hyperplasia to lung adenocarcinoma. The diversity of …
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Evolutionary Trade-offs Between Antimicrobial Resistance and Virulence in Pseudomonas aeruginosa
… costs. PIT-resistant clones showed pronounced phenotypic heterogeneity, ranging from near–wild-type to strongly impaired phenotypes, reflecting diverse evolutionary trajectories. In contrast, STR-resistant clones largely maintained high growth and virulence despite strong resistance, suggesting …
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Accelerating data-driven discovery in type 1 diabetes: an informatics-based approach
… approach for discovery of clinically significant phenotypic heterogeneity in T1D, and (3) development of a highly scalable pipeline to facilitate diabetes health outcomes research using multi-site EHR data. We also substantiate our commitment to openly disseminating our findings and tools to the …
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Feedback regulation in gene networks
… memory. Noise in gene expression, through the phenotypic heterogeneity it promotes, has the potential to be a mechanism implemented by cells to cope with the uncertainties in environmental conditions. By randomly expressing multiple phenotypes, each fit to a certain environment, cells can …
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Breast cancer cells cooperate during invasion and metastasis
… of novel potent therapies.A vast genetic and phenotypic heterogeneity exists among invasive cancer cells. This heterogeneity is important to investigate as, in breast cancer patients, most metastatic nodules are polyclonal and consist of cancer cells that invaded and disseminated collectively. …
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An evaluation of genomic factors and their importance in etiopathogenesis of congenital heart diseases /
… was carried out on 132 subjects with CHDs. Phenotypic heterogeneity and complexity is typical to CHDs. Single nucleotide polymorphism – comparative genomic hybridization genotyping was used and 44 (17.39 percent) pathogenic copy number variations (CNVs) were determined in the group of …
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Genominių veiksnių įvertinimas ir reikšmė įgimtų širdies ydų etiopatogenezėje /
… was carried out on 132 subjects with CHDs. Phenotypic heterogeneity and complexity is typical to CHDs. Single nucleotide polymorphism – comparative genomic hybridization genotyping was used and 44 (17.39 percent) pathogenic copy number variations (CNVs) were determined in the group of …
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Investigation of Rare Genetic Variation in Autism Spectrum Disorder by Genomic Screens
… contributing to <1% of cases. The genetic and phenotypic heterogeneity of ASD reduces the power to identify causative genes. Furthermore, even with the growing number of known ASD genes, our knowledge into the biological pathways underpinning ASD is limited. During my dissertation work I …
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Integrative Multivariate Analysis of Mouse Liver Acini
… zonation. The factors that govern this spatial phenotypic heterogeneity remain inadequately understood and hepatic pathologies persist as major contributors to global mortality rates. This research aimed to address this gap by defining the relationship between the spatial positioning of …
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MULTI-OMIC LINEAGE TRACING PREDICTS THE MOLECULAR DRIVERS OF CANCER STEM CELLS IN TRIPLENEGATIVE BREAST CANCER EVOLUTION.
… poor prognosis is largely driven by extensive phenotypic heterogeneity, sustained by complex genetic and epigenetic interactions that are difficult to dissect without perturbing the native cellular context in which multiple phenotypically distinct subpopulations coexist. Recent advances …
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Suppression of telomerase component dyskerin in human haematopoietic progenitor cells
… length reserve. However, the unexplained phenotypic heterogeneity of these disorders suggest there may be additional mechanisms involved. Dyskerin is a nucleolar protein that stabilises the RNA template component of telomerase, TERC and other small non-coding RNAs of biological importance. …
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Identifying Novel Causes of X-Linked Heterotaxy
… live births. These patients exhibit considerable phenotypic heterogeneity, with structural heart defects significantly contributing to poor outcomes. Variants in several genes can disrupt laterality, but ZIC3 variants, primarily identified through targeted sequencing of its coding region, are the …
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Microglia and Complement in Alzheimer's Disease with Cerebral Amyloid Angiopathy
… factors associated with its genotypic and phenotypic heterogeneity. Cerebral amyloid angiopathy (CAA) is a common, yet frequently overlooked, pathology associated with AD. A pathological hallmark of AD consists of extracellular amyloid-beta (Aβ) deposits, while CAA</p> <p>manifests with …
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