Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"phenotypic analysis"”.
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Phenotypic Analysis of Platelets in Patients with Platelet Function Disorders
… The findings from this thesis help clarify the phenotypic abnormalities associated with PFD, with implications for diagnostic testing. The studies also illustrated that the functional defects in some PFD extend to the ability of platelets to support thrombin generation.
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Genetic and phenotypic analysis of novel South African Avian poxviruses
… penguin (Spheniscus demersus) were chosen for analysis from a larger pool of donated isolates by comparison of macroscopic growth characteristics on chorioallantoic membranes, membrane histology and phylogenetic analyses based on nucleotide alignment of partial P4b sequences. Flamingopox virus …
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Genome sequencing and phenotypic analysis of single cells in cancer
… I present our advances in characterizing the phenotypic behavior of single cells in cancer. We examine the polyfunctional heterogeneity in secretions of ELR+ CXC chemokines from single tumor and stromal cells and demonstrate how the true behavior of single cells can be hidden in bulk assays. …
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Phenotypic analysis of human stem cells and their differentiation potential towards pancreatic cells
Type 1 diabetes is an autoimmune disorder in which the immune system specifically destroys the insulin-producing β-cells of the pancreas, resulting in a loss of glycemic control. There is no cure for the disease, and patients have the difficult task of managing their blood glucose levels by daily …
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Phenotypic Analysis of the Regulatory Role of the Leucine-Responsive Regulatory Protein (LrpPA) in Pseudomonas aeruginosa
<p>Nutrient acquisition is critical to survival and infection by the opportunistic bacterium <em>Pseudomonas aeruginosa</em>. This pathogen expresses a number of virulence factors that are a part of the starvation response and are important in host-pathogen interactions. Additionally, <em>P. …
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Phenotypic Analysis and Localization of Leukocytes at the Site of Intradermal Injection of Phytohemagglutinin in Chickens
… pulp cell suspensions and leukocyte population analysis by flow cytometry, and another GF for histological analysis (Study I). Both studies revealed predominant infiltration of CD4+ T cells and αβ T cells in PHA-injected GFs, with elevated levels observed within 6 h and throughout the 7 d …
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Phenotypic characterization of a clinical HBV/G isolate relative to a co-infecting HBV/A strain and HBV/A/G recombinant strains
… into the HepG2 human hepatoma cell line for phenotypic analysis of each strain. HBV/G, HBV/A and HBV/A/G recombinant strains were isolated from Patient 1, while a different HBV/A/G recombinant strain was isolated from Patient 2. HBV replication capacity was measured using a quantitative real …
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Electrical-phenotyping of the bacterial envelope using microfluidics
… cell viability and physiological capabilities. Phenotypic analysis of bacterial envelopes is challenging due to the small size and low cultivability of microbes. The emerging microfluidic techniques enable quantitative and nondestructive probing of cell envelopes by measuring their physical …
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Identification and characterization of thiamine biosynthesis, transport, and regulation elements among bacteroides species
… in B. thetaiotaomicron. Along with the phenotypic analysis of thiamine acquisition operons in B. thetaiotaomicron we investigated how these deletions impacted its fitness in thiamine deplete and replete conditions. Building on the phenotypic analysis in B. thetaiotaomicron we turned our …
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Mosaic Analysis of Neurogenesis and Neuronal Morphogenesis in Drosophila Learning and Memory Center Mushroom Bodies
… a scaffold protein for E3 ubiquitin ligase. Phenotypic analysis demonstrates that Cul3 is required for proper axon arborization and dendritic elaboration of MB neurons. Chinmo is a novel BTB-zinc finger protein. Functional analysis shows that Chinmo is an important intrinsic factor involved …
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Investigating Hfq-dependent Small Regulatory RNA, Bsr34, and Its Roles in Brucella abortus Physiology and Pathogenicity
… that Bsr34 expression is entirely Hfq-dependent. Phenotypic analysis of a Δbsr34 mutant revealed no defects in in vitro growth or general stress survival but showed significant attenuation in a murine infection model, indicating a specific role in virulence. While an initial chloramphenicol …
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Using Deep Learning to Extract Multicellular Aggregation Features of Myxococcus xanthus
… aggregate segmentation and enabling accurate analysis of multicellular patterns such as rippling waves. We also introduce a deep learning framework for quantitative phenotypic analysis, integrating ResNet and StyleGAN2 into a Variational AutoEncoders (VAEs), and using Siamese architectures as …
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Genetic and phenotypic analyses of auxotrophs requiring aromatic amino acids and vitamins in Streptomyces coelicolor
… relative to argA has not been determined. Phenotypic analysis of the Aro mutants was undertaken. One mutant has a requirement for tyrosine and phenylalanine; one mutant has a requirement for all three aromatic amino acids, tryptophan, tyrosine, and phenylalanine; one mutant has a …
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Immune parameters as predictors of response to maintenance therapy in low grade non-Hodgkin's lymphoma patients
… kill against both KS62 and Daudi targets, phenotypic analysis of circulating lymphocytes, assessment of IL-2 levels after mitogen stimulation of lymphocytes, as well as the determination of plasma IL-2 levels. All these above-mentioned parameters were serially monitored over time in an …
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Investigation of conserved Flagellum proteins in Trypanosoma brucei
… for T. brucei which makes the functional analysis of proteins possible. More than 300 proteins have been identified as components of the T. brucei flagellum but functional analysis of the majority of these proteins has not been carried out to date. This project used a bioinformatics …
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Bioengineered surfaces and hydrogels for specific cell capture and release from whole blood
… rapid enumeration and detailed genetic and phenotypic analysis of rare cell populations.
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Characterisation of the putative Type VII protein secretion system of <em>Streptomyces</em> spp
… agent of common scab of potato. Bioinformatic analysis of the genomes of both S. coelicolor and S. scabies revealed the presence of genes encoding components of putative Type VII protein secretion systems (T7SSs). To investigate the role of these putative T7SSs in S. coelicolor and S. scabies, …
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