Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2313 for “"phenotypes"”.
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Characterizing low-dimensional phenotypes by clustering
… of an organism that can be seen are called phenotypes. Phenotypes that are influenced by multiple genes or the environment; that have many different features; and that vary smoothly over many different values; are called complex phenotypes. These features are called dimensions. Many …
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Intrahost evolution of HIV-1 phenotypes
… immunodeficiency. These studies reveal that the phenotypes of R5 and CXCR4-using HIV-1 may evolve in an adaptive manner during disease progression and transmission.
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Molecular phenotypes associated with heifer fertility
Before the early 2000s, many producers were heavily selecting for production traits without accounting for the negative relationship between many production traits and fertility. The large decrease in fertility that occurred as a result of these selection practices put a heavy burden on producers. …
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Phenotypes and Survival of Hatchling Lizards
The phenotypes of hatchling reptiles are influenced by the environmental conditions that embryos experience during incubation, by yolk invested into the egg, and by the genetic contributions of the parents. Phenotypic traits are influenced by these factors in ways that potentially affect the …
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Multipronged Approach to Study Glaucoma-Associated Phenotypes
<p> Glaucoma refers to a group of conditions characterized by death of RGCs, increase in intraocular pressure is usually a precursor to glaucoma and irreversible optic neuropathy leads to visual impairment and blindness. Recent advances have seen a surge of new ideas and technologies to aid in the …
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The origin of alternative phenotypes in fishes
… that leads to the expression of alternative phenotypes within a species. Such phenotypic expressions are particularly interesting, because the process by which new species are formed typically involves a temporary stage within the splitting species, that is, different heritable and distinct …
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Proxy genotypes and phenotypes for human genetics
… and (2) There are substantial limits to the phenotypes that can be safely elicited or measured. Geneticists thus rely on practically measurable sets of genotypes to proxy for the sequence and human in-vitro models that proxy for in-vivo genetics and physiology while allowing for perturbation …
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The Marfan syndrome and related phenotypes : delineation of various phenotypes and analysis of the fibrillin gene (FBN1) for putative mutations
A clinical and molecular study of patients with unequivocal Marfan sydnrome, or with an undiagnosed connective tissue disorder with some features in common with Marfan syndrome. Presents the phenotype of six Marfan patients with an FBN1 mutation, patients with Shprintzen-Goldberg syndrome or …
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Genetic Control of Experimentally Induced Reproductive Autoimmune Phenotypes
… phenotype including loci linked to other phenotypes and suggested that some genes may be important only to a single phenotype while others may affect multiple autoimmune diseases. Sequencing of candidate genes for Aod2 and Aod5 showed polymorphisms between resistant and susceptible …
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Development of compartment phenotypes in the mammalian striatum
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1997.
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Characterization of Tau Oligomeric Strains: Implications for Disease Phenotypes
Neurodegenerative diseases are prevalent, costly and debilitating conditions that are commonly characterized by the aggregation of tau protein. While original studies of Alzheimer’s disease noted the presence of tau aggregated into large, insoluble fibrillar structures known as neurofibrillary …
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RELATING METABOLIC PHENOTYPES TO MOVEMENT BEHAVIOR IN BROOK TROUT
… failing to explain the phenomenon. Metabolic phenotypes have been suggested as a possible driver for expression of different movement life histories. I investigated if metabolic phenotypes are related to movement strategies within a population of brook trout (<em>Salvelinus fontinalis</em>) in …
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Distributional Fingerprinting of Cell Population Phenotypes and Drug Activities
<p>From gene expression to protein abundance, biological measurements have traditionally been taken as population averages. Studies over the past decade, however, have established the biological relevance of population heterogeneity, even for cells with identical genetic background. The …
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Early life phenotypes of type 1 diabetes genetic risk
… candidate genes that influence the archetypal phenotypes of the disease prodrome, which starts early in life, as a means of shedding light on the heterogeneity of data and sign-posting mechanisms. Based on prior ‘biological’ knowledge I selected T1D SNPs conjectured to affect growth mediated by …
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Image-based pooled genetic screens for complex cellular phenotypes
… such as pooled CRISPR screening, the cellular phenotypes that can be linked to gene function in a pooled screen have been restricted to measurement by sequencing, and are often a step removed from the biological process of interest. In contrast, microscopy provides a high-throughput and …
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The role of dosage sensitive genes in aneuploid phenotypes
… A central question is whether aneuploid phenotypes are the consequence of copy number changes of a few especially harmful genes that may be present on the extra chromosome, or are caused by copy number alterations of many genes that confer no observable phenotype when varied individually. …
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Screening and Engineering Phenotypes using Big Data Systems Biology
… applied to predicting and modifying the emergent phenotypes produced by complex biological systems. In this research, several novel tools were developed to assist in the acquisition and analysis of biological big data for a variety of applications. In total, two entirely new tools were created and …
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