Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"phenotype switching"”.
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RNA EXPORT FACTOR ELF1 MAINTAINS GENOME STABILITY IN FISSION YEAST
… prions or other epigenetic phenomena, cause the phenotype switching. This suggests Elf1 is required to maintain genome stability. Since RNAs accumulate in the nucleus of elf1Δ cells due to an RNA export defect, I hypothesized that excess RNAs in the nucleus may increase formation of DNA-RNA …
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Population dynamics of bacterial persistence
… explained with a two state model for reversible phenotype switching in a cell within the population. We study this existing model with a new theoretical approach and present analytical expressions for the time scale observed in population growth and resuscitation, that can be easily used to …
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Assessing the immune phenotype of cardiac syndrome x: a prospective study of biomarkers
… in CSX patients. This could allow phenotype switching in vascular smooth muscle cells with the resultant vascular remodelling causing reduced vessel responsiveness to local rheological stimuli and reduced luminal diameter with consequent increased microvascular resistance during …
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Co-regulation of the Smooth Muscle Cell Alternative Splicing Programme by the RNA-Binding Proteins RBPMS, RBFOX2, MBNL1, and QKI
The phenotypic switching of vascular smooth muscle cells (VSMCs) from a contractile /differentiated state to a synthetic/ proliferative state is a hallmark of many cardiovascular diseases, driven in part by extensive alternative splicing (AS) regulation. RBPMS, a master splicing regulator in …
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Determining The Genotype-Phenotype Connection In Synthetic Inducible Gene Expression Systems
… the genotype controls an individual cell’s phenotype. However, even genetically identical cells display a variety of phenotypes, which may be attributed to differences in their environment. Yet, even after controlling for these two factors, individual phenotypes still diverge due to noisy …