Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"phenotype association"”.
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Functional interpretation of cancer-associated genetic variants
Genome-wide association studies have hitherto identified several common genetic variants that may significantly modulate cancer susceptibility. However, the precise molecular mechanisms behind these associations remain largely uncharacterized, creating barriers to understanding the biological …
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Facilitating Pharmacogenetic Association Studies Using an Extensible Genotype Information Management System
… data with the intent to facilitate genotype-phenotype association studies and catalyze pharmacogenomic research. COBRA-DB is an internal, proprietary application in use by the Division of Clinical Pharmacology at Indiana University School of Medicine.
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Genomics of Climatic Adaptation in Populus Trichocarapa
… to uncover relationships between genotype, phenotype, and environment. We detected strong correlations between adaptive phenotypes, climate, and geography, which suggested climatic selection driving adaptation of these populations to local environments. We subsequently combined …
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Statistical Inference For High Dimensional Models In Genomics And Microbiome
… for high dimensional models to address the association between microbiome compositions and certain outcomes. The high-dimensionality and compositional nature of the microbiome data make the naive application of the classical regression models invalid. To study the association between …
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Fine mapping of the protein QTL cqSeed protein-001 from PI 407788A and genome-wide association mapping in the soyNAM populations using DNA cytosine methylation
Soybean [Glycine max (L.) Merr.] is a leading source of vegetable protein and oil with dynamic uses in food, industry, and animal feed. Given the reduced genetic diversity resulting from rapid domestication and years of selective breeding, it is imperative to find new sources of genetic variation …
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Evaluating and Improving Performance of Bisulfite Short Reads Alignment and the Identification of Differentially Methylated Sites
… is essential for understanding genotype phenotype association, gene and environment interaction, diseases, and cancer. The thesis work first evaluates the performance of several commonly used bisulfite short read mappers and investigates how pre-processing data might affect the …