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Showing 1 to 20 of 21 for “"phenothiazine"”.
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The electrochemistry of phenothiazine derivatives
Methylene blue derivatives (MBDs) such as methylene blue (MB -), 1-methyl methylene blue (1MMB) and 1,9-dimethyl-methylene blue (DMMB) have potential use as drugs within photodynamic therapy (PDT). Knowing the redox properties of MBDs will help in understanding the way in which MBDs interact with a …
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The molecular structures of chlorpromazine and thiethylperazine and a discussion of the action mechanism of the phenothiazine derivatives
A very important group of the derivatives of phenothiazine are termed the major tranquillizers. The introduction into clinical psychiatry by Delay and Deniker in 1952 of chlorpromazine and its analogues has revolutionized the treatment of psychotic conditions and of mental diseases in general. …
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Towards Self-assembling Multichromophoric Materials for Organic Semiconductors
… are commonly used in electronic devices. First, phenothiazine derivatives were synthesized and optical and electrochemical properties were studied as potential electron donor chromophores. These phenothiazine derivatives were found to have large Stokes shifts associated with a large geometry …
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Design, Synthesis, And Evaluation Of Molecular Inhibitors For Biologically Relevant Enzymes
… novo design and in silico screening of a set of phenothiazine molecules for the inhibition of II-HMGR. These molecules were synthesized and assayed against II-HMGR, resulting in the identification of a substituted phenothiazine compound found to inhibit II-HMGR with an IC50 of 130 µM. This work …
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Non-Neuroleptic Antitubercular and Anticancer Therapeutics through Rational Drug Remodelling of Phenothiazines and Related Antipsychotics
… clinically approved non-antibiotics including phenothiazines hold promise as novel classes of therapeutics in other indications. However, in addition to inherent neuroleptic properties, phenothiazines and related antipsychotics elicit adverse side effects at clinically relevant doses thus …
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The effect of tranquilizing agents on diadochokinetic movement in a senile psychotic population
… is the effect of tranquilizers, specifically phenothiazines , on diadochokinetic movement in a geriatric population? It was hypothesized that patients exhibiting overt effects of long term phenothiazine therapy (dyskinesia ) would show a reduced rate of diadochokinetic movement when compared …
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Characterising Triflupromazine as a potential agent to treat glioblastoma multiforme
… identified Triflupromazine, a brain-penetrant phenothiazine as a potent inducer of significant cell death in multiple glioma stem cells lines. Further experiments on its underlying molecular action suggested an unexploited off-target mechanism that is separate from its known dopamine …
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Di- und Triphenothiazine - neue Modellsysteme für redoxschaltbare molekulare Drähte
… Phenothiazinboronsäureester und ethinylierte Phenothiazine als Ausgangsmaterialien für die Suzuki- und Sonogashira-Kupplung dargestellt. Arylierte und alkinylierte Phenothiazine waren in guten Ausbeuten zugänglich. Die grünlich fluoreszierenden arylierten und alkinylierten Phenothiazinderivate …
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Application of natural dyes in textile industry and the treatment of dye solutions using electrolytic techniques
… indicated that between 84 to 100% of each dye of phenothiazine was removed during 60 minutes of electrolysis. The percentage removals for the phenothiazine dyes followed the following decreasing order: (MG ≈ MV) > (DMMB ≈ AA) > (AB ≈ AC ≈ NMB) > TBO > TH. However, the azine, acridine and oxazine …
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A Clinical Investigation of the Use of Promazine Hydrochloride for Pre-Delivery Sedation
… new drugs, among which are those derived from phenothiazine. Chlorpromazine (Thorazine) has been used and reported extensively. Promethazine has received prominent attention, and for the last several years has been used routinely on the University Service at the Creighton Medical Center. These …
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Novel Catholyte and Electrolyte Optimisation for Aqueous Organic Redox Flow Batteries
… Chapter 4 explores commercially available phenothiazine dyes. Nicotinamide (NA) was used to increase solubility, specifically, the solubility of the most promising candidate explored, azure-a (AA), was doubled from 1 M to ca. 2 M. When cycled with NA in the supporting electrolyte, AA, had …
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Studies on the oxidative degradation of fluphenazine decanoate in oily solution
… decanoate, a member of the neuroleptic phenothiazine drugs, is believed to occur in oily solution via the hydroperoxides formed as a result of autoxidation of the oil. Synthesis and characterisation of the expected oxidation products of the drug was undertaken so that the formation of …
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Synthetic Materials with Redox-Triggers for Imaging and Drug Delivery
… probe, p-nitrobenzyl 3,7-bis(dimethylamino)-10h-phenothiazine-10-carboxylate for the selective imaging and therapy. Conjugating methylene blue with a p-nitrobenzyl moiety enables it to quench electron transfer within the molecules. Moreover the redox trigger caged probe released active methylene …
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Spectroscopic Studies of Some Semiquinone Radical Ions
… products were only detected in the case of phenothiazine.
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Molecular dynamics studies of the structure–dynamics relationship in concentrated nonaqueous electrolytic solutions
… hetero-charge network, and the other containing phenothiazine organic catholyte preferring softer homo-radical stacking. For the latter, conductivity data show that a faster charge transport is present at high electrolyte concentrations. This difference in behavior becomes less pronounced as the …
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Greener Photoredox-Catalyzed Phosphonations of Aryl Halides
… following order: First, the discovery that 10H-phenothiazine (PTZ) enables the transition metal-free phosphonation of aryl halides using trialkyl phosphites will be presented. PTZ serves as a photocatalyst capable of reducing the aryl halide to access aryl radicals, which readily couple with …
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Photoelectrochemical tandem cells with enzymes wired to hierarchically-structured electrodes for solar fuel synthesis
… IO-ITO electrode with an Os complex-based and a phenothiazine-based polymer. Subsequently, a bias-free tandem semi-artificial cell was assembled, that wired PSII to hydrogenase for overall solar-driven water splitting. This PEC cell integrated the red and blue light-absorber PSII with a green …
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Repurposing chlorpromazine and its metabolites for antituberculosis drug discovery
… generate metabolites of chlorpromazine (CPZ), a phenothiazine with demonstrated in vitro activity against Mtb, and to investigate their potential utility in combination with anti-TB drugs. 7-HydroxyCPZ (M2), CPZ-N-oxide (M3), CPZ sulfoxide (M1), nor-CPZ (M5), nor-CPZ sulfoxide (M6b) and …
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