Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"phase II enzymes"”.
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The Mechanism of Chemoprotection by 1-Cyano-2-Hydroxy-3-Butene, a Natural Component of Cruciferous Vegetables
… was through a monofunctional increase in phase II enzymes, particularly, the GST subunit Yc$\sb2.$ (Abstract shortened by UMI.).
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Identification and Characterization of A Zebrafish Glutathione S-Transferase Pi
… S-transferases (GSTs) are a major group of Phase II enzymes involved in the detoxification of certain endogenous compounds such as reactive oxygen species (ROS) generated during metabolism, as well as in the detoxification of xenobiotics including drugs. In recent years, the zebrafish has …
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Assessing Hepatic Gene Expression in Response to Xenobiotic Exposure in Mice
… are plant derived compounds metabolized by phase I and II liver enzymes. Phase I enzymes increase, and phase II enzymes decrease, xenobiotic toxicity. Xenobiotics considered were ergotamine, associated with fescue toxicosis, and sulforaphane, a phase II inducer. Hypothesized responses in …
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Neuroprotective Effects of Sulforaphane and the Involvement of Autophagy
… confirmed that SFN can induce Nrf2-driven phase II enzymes, as determined by qPCR as well as immunoblotting. The elevation of the main autophagy marker light chain 3-II (LC3-II) by SFN could be observed dose-dependently at protein level. In addition, SFN pre-treatment provided statistically …
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ANALYSIS OF ELECTROPHILE-INDUCED NRF2 GENE ACTIVATION
… factor Nrf2 regulates expression of phase II enzymes and other adaptive responses to electrophile and oxidant stress. Nrf2 concentrations are regulated by the thiol-rich sensor protein Keap1, which is an adaptor protein for Cul3-dependent ubiquitination and degradation of Nrf2. …
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Effect of benzylglucosinolate on signaling pathways associated with type 2 diabetes prevention
… potential by inducing detoxicating phase II enzymes and increasing glutathione (GSH) levels in tissues. In T2D diabetes an increase in gluconeogenesis and triglyceride synthesis, and a reduction in fatty acid oxidation accompanied by the presence of reactive oxygen species (ROS) are …
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Sulforaphan und Selen : Einfluss auf Phase II Enzyme und Selenoproteine sowie deren Effekt auf die entzündungsvermittelte Dickdarmkanzerogenese
… und Se auf die Aktivität sowie Expression von Phase II Enzymen und Selenoproteinen untersucht. Der Einfluss der Kombination von SFN und Se auf die unter physiologischen Bedingungen stattfindende Proliferation und Apoptose war ebenso Gegenstand der Arbeit wie die Modulation von …