Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"phase II clinical trial"”.
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Topics in Bayesian adaptive clinical trial design using dynamic linear models and missing data imputation in logistic regression.
Conventional Phase II clinical trial designs usually employ a logistic regression model to analyze the efficacy of a new drug and, therefore, assumes monotone dose-response relationship. Also, the logistic regression model requires the response to be categorical and, thus, it is not applicable for …
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Joint Network Modeling of Omics Data for Understanding Complex Diseases
… function in the omics networks of multiple clinical groups. Applying this strategy to proteomic data from a phase II clinical trial investigating the effect of neoadjuvant therapy in breast carcinomas, I identify potential mechanisms for disease progression and treatment response. In …
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Bringing Til Therapy Beyond Melanoma: Advancing The Treatment of Advanced Pancreatic and Ovarian Cancers
… not seem to be sufficient to generate a strong clinical response, approaches involving <em>ex vivo</em> manipulation of immune cells, such as adoptive cell therapy (ACT) using autologous TIL, might be able to provide therapeutic benefit. The effectiveness of TIL ACT has been demonstrated in …
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Bayesian Adaptive Designs For Proof-of-Concept Trials and Platform Trials
… the traditional drug development paradigm in phase II trials becomes increasingly inefficient due to its slow progress, high cost, and high failure rate. Fitting one standard strategy to all different trials also harms its reliability in decision-making because it doesn’t fully use all …
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An investigation of novel therapeutic strategies for the treatment of multiple sclerosis and autoimmunity
… receptor agonist is currently being tested in a phase II clinical trial for its ability to promote remyelination [“CCMR One” trial]. Here, we focused on the ability of bexarotene to modulate the human Th17/iTreg axis in vitro, owing to literature reporting that RXR ligands augment RAR agonists’ …
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Promoting and measuring remyelination and neuroprotection in clinical trials of people with multiple sclerosis
… strategy to delay or prevent the progressive phase of MS is to promote endogenous remyelination; doing so restores nerve conduction and prevents demyelinated axons from degenerating. The rate-limiting stage in this process is differentiation of oligodendrocyte progenitor cells (OPCs) into …
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Challenges facing clinical trial design in oncology
Background: Clinical trials are designed to help patients to live better and/or longer. Each component considered in the design of the trial has the potential to shape and impact the ultimate result. Interpretation of a trial as positive or negative hinges on the endpoint of interest and the trial …
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Advancing precision medicine: harnessing data from diverse sources and individuals to predict medication efficacy and safety.
… medication treatment. These sources include clinical studies and multi-omic data, as well as real-world data (RWD) such as electronic health records (EHRs). My passion for this research area stems from a deep-seated commitment to enhancing patient outcomes by optimizing medication selection …
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Development and evaluation of new leprosy skin test antigens as diagnostic tools
… infected individuals before the onset of clinical symptoms continues to be one of the greatest needs in the field. Preclinical diagnosis would expedite the delivery of chemotherapy to patients, prevent disabilities, decrease stigma, intercept transmission, and measure the true incidence of …
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Bayesian Designs For Early Phase Clinical Trials With Novel Target Agents
… mainly focus on Bayesian designs for early phase clinical trials with novel target agents. It includes three specific topics: (1) reviewing novel phase I clinical trial designs and comparing their operating characteristics; (2) Proposing a Bayesian optimal phase II clinical trial (BOP2) …
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The role of SRC family kinases in the development and progression of prostate cancer
… compounds have been developed and are now in Phase II clinical trial in patients with castration-resistant prostate cancer. However, there is considerable lack of data regarding the role of SFK expression and activation in prostate cancer in clinical settings. In this thesis, we studied the …