Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"pharmacovigilance"”.
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Patients centred pharmacovigilance
In recent years, periodically high peaks of attention and publications have documented severe adverse reactions to new molecules, which have raised many questions about the efficacy- efficiency of traditional methodological tools of phannacovigilance, as well as about the role of regulatory …
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Pharmacovigilance study using Electronic Medical Records
… propose a new approach for applying quantitative pharmacovigilance method based on disproportionality analysis (DA) into EMR data. This proposed approach has been proven to sufficiently detect adverse reaction signals. Also, a system that can automatically perform DA analysis using EMR data was …
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Reducing medication errors in Kuwaiti government hospitals through pharmacovigilance
… errors in Kuwaiti government hospitals through pharmacovigilance involves the improvement of medication management practices to achieve the desired outcome. Medication management practices were assessed and based upon the findings, training to enhance healthcare professional’s awareness was …
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Pharmacovigilance in Post-Marketing: Risk Assessment and Reporting Standards
<p>While there has been new targeted drug therapies released into the market over the recent years, pulmonary arterial hypertension (PAH) remains to be a rapidly progressive disease with poor prognosis. Over time the arteries stiffen and tighten subsequently leaving the heart to pump harder to try …
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Incidence of adverse drug events in COVID-19 patients on anticoagulants: a pharmacovigilance study
Pharmacovigilance is a crucial component of today’s health science studies that allows researchers to detect, assess, understand, to ultimately prevent any adverse event associated with drugs. Today, with the world struggling to get the COVID-19 pandemic under control, it is important to look at …
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Probabilistic modeling of the drug development domain: A Bayesian domain-knowledge application for pharmacovigilance
A recent analysis by the Tufts Center for the Study of Drug Development estimates that the cost of developing a single new chemical entity (NCE) into a successful therapeutic agent is $802 million. This figure is largely dependent on the expense of investigating NCEs that ultimately fail to be …
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Role of pharmacists in adverse drug reaction reporting in Holy City of Makkah, Saudi Arabia. Characterisation of models for evaluating Pharmacovigilance in the Holy City of Makkah and attitude and awareness of pharmacists towards Adverse Drug Reaction Reporting.
… have in place a system, conventionally known as Pharmacovigilance. The aims of Pharmacovigilance are to identify, quantify and continuously monitor all drug use through a system which would enable all health care professionals such as physicians, pharmacists, dentists and nurses to contribute. …
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Δεδομένα φαρμακοεπαγρύπνησης των PARP inhibitors στον καρκίνο ωοθηκών και μαστού / Pharmacovigilance data of PARP inhibitors in ovarian and breast cancer
Η φαρμακοεπαγρύπνηση έχει σημαντικό ρόλο στην διασφάλιση της δημόσιας υγείας μέσω της ανίχνευσης, της αξιολόγησης και της πρόληψης των ανεπιθύμητων ενεργειών και ειδικά στον τομέα της ογκολογίας όπου η τοξικότητα των φαρμάκων είναι αρκετά υψηλή. Οι PARP αναστολείς (Poly ADP-Ribose Polymerase …
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Pharmacovigilance: A comparative study about the knowledge of adverse drug reaction (ADR) reporting that private practitioners and government doctors gained in a random locality in India
<p>The present pilot study aims to compare the knowledge pertaining to ADR reporting systems that government doctors and private practitioners gained in a random, tier-II city in India, by conducting a questionnaire based survey. Their knowledge of ADR reporting, related guidelines and/or …
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Assessing the effectiveness and challenges of adverse drug reaction reporting systems: a systematic review
… to be a vital yet multifaceted element of pharmacovigilance (PV). A significant contrast in the nature of challenges and proposed solutions between High‑Income Countries (HICs) and Low‑ and Middle‑Income Countries (LMICs) was identified, with behavioural and systemic barriers predominant in …
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Extracting Information on Dietary Supplements from Clinical Notes in Electronic Health Record Systems Through Natural Language Processing Techniques
… need to use alternative data sources for active pharmacovigilance on DS safety, which can be addressed through leveraging clinical notes in the electronic health records (EHR), a valuable data source documenting comprehensive real-world information with respects to patient safety in the course of …
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An Expandable Stage-Based Machine Learning and Statistical Pipeline for Detecting Adverse Drug Reaction Risks on Complex Multidimensional Datasets
… validation, and exploration in national pharmacovigilance datasets.
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Exploring machine learning techniques using patient interactions in online health forums to classify drug safety
… of patient derived data of this type for pharmacovigilance – the study of drugs once released to market for safety. It is believed that this is the first application of machine learning and natural language processing techniques to be used for pharmicovigilance on patient derived data. We …
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Informing Public Health Policy Design and Operations with Analytics: Methods and Applications
… chapter of the thesis focuses on post-marketing pharmacovigilance, which is key to drug safety regulatory work. It presents PR1SM (Patients Really are 1st in Signal Management), an AI-based framework for identifying potential drug safety signals using post-marketing surveillance data. By …
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The Social Organization of Opioid Use for Chronic Pain
… practices through new forms of opioid pharmacovigilance, surveillance, and punishment. In response to these modes of surveillance and punishment, physicians have responded by adopting work practices that demonstrate their compliance with and accountability to these regimes of ruling. …
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The role of a pharmacist in screening, communicating and reporting the risks of cardiovascular disease associated with non-steroidal anti-inflammatory drugs and the perception of the population
… highlighted systemic barriers to effective pharmacovigilance. To further contextualise these findings, qualitative interviews with members of the public explored perceptions of community pharmacy services. Thematic analysis identified four primary barriers: limited public awareness of …
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Application of Hyper-geometric Hypothesis-based Quantication and Markov Blanket Feature Selection Methods to Generate Signals for Adverse Drug Reaction Detection
Pharmacovigilance is the science relating to all concerns about drug safety, especially ofmanaging the risk associated with medications. It serves as a complementary approach toclinical trial. Spontaneous Reporting Systems (SRS) had been constructed world-widely tofacilitate tracking the risk of …
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THE ROLE OF HYPOGLYCEMIC AGENTS IN AMELIORATING COGNITIVE FUNCTIONS AND PSYCHIATRIC SYMPTOMS: FROM THE PSYCHIATRIC PATIENT TO EVIDENCE-BASED AND PHARMACOEPIDEMIOLOGIC APPROACHES FOR SUPPORTING THE CLINICAL PRACTICE
… analysis of concomitant therapies in pharmacovigilance databases were used to explore all antidiabetic drugs (ATC code: A10) in combination with antidepressants. Survival analysis was performed using Danish healthcare registers to evaluate the potential benefits of GLP-1 analogues …
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Optimization of Signal-Detection Methods in Novel Databases: a Focus on Direct-Acting Antivirals
… regression. Lastly, there is interest in pharmacovigilance and pharmacoepidemiology in using real-world data as a complementary data stream to spontaneous report databases. The current study used medical and pharmacy claims from the Merative MarketScan Commercial Databases to evaluate and …
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