Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"pharmacometric modelling"”.
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Pharmacometric modelling to inform and improve TB and HIV treatment: Focus on drug-drug interactions and neglected populations
… population pharmacokinetics and pharmacodynamic modelling to improve TB and HIV treatment in neglected populations using data from patients with TB or/and HIV. We analyse the pharmacogenomics, pharmacokinetics, and drug-drug interaction of efavirenz, isoniazid, and bedaquiline in pregnant women …
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Advancing tuberculosis treatment through pharmacometric modeling of drug exposure and biomarkers
… treatment approaches. In this thesis, I utilized pharmacometric modelling and data from drug-susceptible pulmonary tuberculosis patients as well as in vitro data to characterise the pharmacokinetics (PK) and pharmacodynamics (PD) of first-line anti-tuberculosis drugs and tuberculosis biomarkers. A …
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Addressing challenges in the treatment of tuberculosis and tuberculosis meningitis: a pharmacometric approach
… complicate management. In this thesis, we use pharmacometric modelling and simulation approaches to tackle some of the obstacles encountered in TB and TBM treatment. Firstly, we demonstrate how pharmacometric approaches can x be useful in monitoring adherence to TB drugs. Secondly, we …