Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"pharmacological target"”.
-
IGF1R as a pharmacological target in allergic asthma and cancer-promoting factor in the lung tumor microenvironment
IGF1R (receptor del factor de crecimiento similar a la insulina tipo 1) es una tirosina quinasa ubicua que modula múltiples funciones celulares, como la proliferación, el crecimiento, la diferenciación y la supervivencia. El asma es una enfermedad pulmonar crónica caracterizada por obstrucción …
-
Mitochondrial permeability transition following calcium overload. - Its role in neuronal cell death and potential as a pharmacological target.
There is currently no clinically available drug with neuroprotective properties to limit the evolving cell death following e.g. stroke or traumatic brain injury. The mitochondrial permeability transition (mPT) is a potential pathological mechanism causing cell death in the CNS. As the name implies, …
-
Functional Characterization of CRIP1a Knockout Mice
… amygdala. Thus, CRIP1a might serve as a future pharmacological target for studying and treating anxiety disorders.
-
Regulation of IGFBP-5 and Osteoblast Functions by Nuclear Factor I
… Growth Factor (IGF) system is a major target of GC inhibition in bone. We found that GCs inhibit expression of IGF binding protein-5 (IGFBP5) which binds IGFs and stimulates osteoblast activity by IGF dependent and independent mechanisms. GC-induced inhibition of IGFPB5 promoter …
-
Novel approaches towards pharmacological enhancement of motivation
This work explores novel approaches towards pharmacological enhancement of motivated behaviour. A loss of motivation remains a severe unmet clinical need in a number of neuropsychiatric and neurodegenerative disorders. The work described in this thesis, can be divided into two sections. Initially, …
-
Aldehyde dehydrogenases (ALDH) expression in cancer tissues as potential pharmacological targets for therapeutic intervention. Probing ALDH expression and function in 2D- and 3D-cultured cancer cell lines
… was found not to be involved in inhibiting the pharmacological effect or causing resistance to different cytotoxic and molecularly targeted anticancer drugs. To unravel the functional role of ALDH7A1, 9 compounds obtained from a virtual screening of 24,000 compounds from the Maybridge collection …
-
Aldehyde dehydrogenases (ALDH) expression in cancer tissues as potential pharmacological targets for therapeutic intervention. Probing ALDH expression and function in 2D- and 3D-cultured cancer cell lines
… was found not to be involved in inhibiting the pharmacological effect or causing resistance to different cytotoxic and molecularly targeted anticancer drugs. To unravel the functional role of ALDH7A1, 9 compounds obtained from a virtual screening of 24,000 compounds from the Maybridge collection …
-
Aldehyde dehydrogenases (ALDH) expression in cancer tissues as potential pharmacological targets for therapeutic intervention. Probing ALDH expression and function in 2D- and 3D-cultured cancer cell lines
… was found not to be involved in inhibiting the pharmacological effect or causing resistance to different cytotoxic and molecularly targeted anticancer drugs. To unravel the functional role of ALDH7A1, 9 compounds obtained from a virtual screening of 24,000 compounds from the Maybridge collection …
-
Induction of Interleukin-1(beta) Converting Enzyme in the Brain and Its Role in Anorexia Induced by Centrally Administered Lipopolysaccharide
… anorexia and indicate ICE may be a viable pharmacological target for inhibiting this response.
-
Internally Translated Cx43 Isoform GJA1-20k Affects Epithelial to Mesenchymal Transition and Metastatic Cancer Cell Behavior
… remodeling could be promising as a potential pharmacological target process independent of transcriptional or post-translational pathways. Ultimately, by adding novel information in the expanding and compelling field of translational control, this work could aid in developing the future of …
-
Alpha Synuclein Oligomers in Human Pathology: Significance of Nitrative Alpha Synuclein Modifications
… αSyn in humans and may thus constitute a viable pharmacological target. These data also suggest that nitrative modifications of small amounts of αSyn, although not particularly toxic per se, may seed unmodified local αSyn to form stable oligomers that possess increased neurotoxicity. This …
-
Pharmacological regulation and function of store-operated calcium channels
… to allow Ca²⁺ influx. In this thesis, the pharmacological aspects andregulatory mechanisms of SOCE were investigated using HEK293 cells overexpressing STIM1, ORAI or TRPC genes. The expression and function of TRPC channels and their spliced variants in native cells were also examined.Using …
-
In vitro and in vivo studies on the activating platelet collagen receptor glycoprotein VI in mice
… to evaluate its potential as an antithrombotic target. The first mAb against (mouse) GPVI, JAQ1, was generated and used to demonstrate that GPVI requires the FcRgamma-chain for its expression and function and that this receptor is the central molecule in collagen-induced platelet activation. …
-
Neuropharmacological Mechanisms Underlying Incentive Salience and Stress
… behavior. Using a combination of genetic and pharmacological tools, the role of individual opioid receptors in restoring approach behavior suppressed by stress in the NIH test was next dissected. These studies identified the mu opioid receptor as a critical mediator of approach behavior and a …
-
PORPHYRIN DERIVATIVES AS VERSATILE PROTEASOME MODULATORS
… For this reason the proteasome has become a pharmacological target for cancer and neurodegenerative diseases where opposite effects are desirable, inhibition and activation respectively. Interestingly, accumulation of the ubiquitin-conjugated proteins, which have been tagged for degradation, …
-
Modulation of heme oxygenase-1 activity by novel synthetic compounds for pharmacological applications
… oxygenase (HO) has been regarded as a potential pharmacological target, especially the inducible isoform, heme oxygenase-1 (HO-1). HO catalyzes the rate-limiting step of endogenous heme degradation, releasing carbon monoxide (CO), free iron (Fe2+), and biliverdin (BV), then reduced to bilirubin …
-
ROLE OF ASGR1 IN METABOLIC SYNDROME, OBESITY, AND ATHEROSCLEROSIS
… Furthermore, total plasma N-glycome and untargeted liver proteomics were carried out for functional analysis. Second, to evaluate the lipid metabolism and atherosclerosis, we backcrossed ASGR1-/- with LDL-R-/- and ApoE-/- mice, generating DKO mice lacking ASGR1-/-/LDL-R-/- or …
-
Resistance to Apoptosis in Smooth Muscle Cells and Stent-Induced Stenosis in Coronary and Peripheral Arteries
… restenosis in one artery may serve as a pharmacological target in another artery that does not express the same characteristic.
-
Investigations into the cellular and molecular changes in the amygdala in models of temporal lobe epilepsy and maternal immune activation
… in epilepsy with GAT-1 being an attractive pharmacological target. Electron microscopy was used to examine the distribution, expression and morphology of GAT-1 expressing structures in the amygdala of the TLE model. Results suggest that GAT-1 was preferentially expressed on putative axon …
-
Identification and Characterization of the Mechanisms of Action of Novel Antiviral Compounds Targeting the Minimal Replication-Transcription Complex of SARS-CoV-2
… the RNA polymerase RNA dependent (RdRp) is the pharmacological target of two of the three drugs currently in clinical use for the treatment of COVID-19, namely remdesivir and molnupiravir. However, the absence of strong evidence of in vivo efficacy and safety still calls for the development of …
Page 1 of 2