Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"pharmacological modulation"”.
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Pharmacological modulation and manipulation of cancer drug resistance
The aim of this project was to investigate pharmacological methods of overcoming resistance in cancer. Novel compounds, targeted therapies and non-steroidal anti-inflammatory drugs (NSAIDs) were examined for their potential to modulate and manipulate specific forms of drug resistance. Sixty one …
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Physiological and pharmacological modulation of renal water reabsorption.
Contains fulltext : 91331.pdf (Publisher’s version ) (Open Access)
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Pharmacological modulation of insulin resistance - benefits and harms
Aims: Thiazolidinediones have been advocated as second or third line insulin sensitizing agents in the management of type 2 diabetes (T2DM). Their widespread use has been hampered by concerns about their cardiovascular safety, including fluid retention. Metformin is established as first-line …
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Pharmacological Modulation of Macrophage Cytotoxicity: Role of Protein Kinases
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1987.
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EFFECTS OF OPTOGENETIC ACTIVATION AND PHARMACOLOGICAL MODULATION OF DOPAMINE NEURONS
<p>This study explored the use of optogenetic tools to better understand treatments used for schizophrenia. The “positive” symptoms (e.g., hallucinations, paranoia, etc.) of schizophrenia may come from overexpression of dopamine in mesolimbic dopamine neurons. Positive symptoms can be produced in …
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PHARMACOLOGICAL MODULATION OF THE ADAPTIVE IMMUNE SYSTEM IN ISCHAEMIC HEART DISEASE
Inflammation plays a key role in the disease processes of both atherosclerosis and myocardial infarction (MI). Regulatory T (Treg) cells are a subset of the adaptive immune system involved in immune tolerance. Animal models show that increasing Treg cell numbers in atherosclerosis can limit disease …
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Pharmacological Modulation of Cancer Migration and Invasion Through Targeting AQP1 Ion and Water Channel Activity
… The aims of this thesis were to test whether pharmacological block of the aquaporin-1 water and ion channel would impede cell migration and invasion in aquaporin-1-expressing cancer cell lines, and to see if the efficacy of aquaporin-1 inhibitors depended on membrane localisation of the …
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Pharmacological modulation of learning and memory in mice and zebrafish: Implications for Alzheimer’s disease animal models
… are some reasons for its popularity in genetics, pharmacological and behavioural research. As vertebrates, zebrafish share considerable sequence similarity with humans and are being used as an animal model for various human disease conditions. Here a video and written protocol is presented for the …
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PHARMACOLOGICAL MODULATION OF SARCOPLASMIC RETICULUM CALCIUM ATPASE AND CALCIUM RELEASE CHANNELS FOR MUSCLE CELL PROTECTIVE ACTION
… namely ischemia-reperfusion injury. Pharmacological agents used therapeutically for cell protection, especially for cardiac protection in ischemic heart diseases, have only directly targeted one of the elements regulating Ca2+ homeostasis, the L-type Ca2+ channels (calcium channel …
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Vasomotor and anti-oxidant effects of anti-ischaemic therapies.
… factors reponsible for poor responsiveness and pharmacological modulation of these responses.
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Roles of the P2X7 receptor in C6 astroglioma: in vitro and in vivo studies
… Blue G (BBG). The in vivo study examined whether pharmacological modulation of P2X7R with BBG altered tumor growth. C6 glioma cells were implanted into the striatum of rat brain and in situ P2X7R expression was shown to be associated with glioma cells and resident microglia. Preliminary results …
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I: Catalytic Direct C-H Arylation of Pyrazoles. II: Toward Modulation of Neuroplasticity with Small Molecules
… 2, the TrkB receptor as a potential target for pharmacological modulation is examined. Its signaling, role in brain disease, and reported agonists and antagonists are reviewed. In addition, our attempts at establishing an assay to assess TrkB activation, as well as our results using the reported …
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The Impact of Melanocortin Receptor Ligands on Astrocyte Signalling and Metabolism
… the expression of all MCRs and the impact of pharmacological modulation on astrocytic signalling pathways, ion dynamics and metabolism. It explores how melanocortin peptides influence metabolic functions in astrocytes, particularly focusing on mitochondrial and glycolytic activity, ERK1/2, PKA …
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Investigation of chemotherapy-induced peripheral neuropathy-related behaviour in male and female ratsa role for the endocannabinoid system
… a clinically significant component of CIPN, yet pharmacological treatments to manage it effectively remain limited, underscoring the need to elucidate the underlying neurobiological mechanisms. Accumulating evidence suggests that the endocannabinoid system represents a promising therapeutic …
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PERICYTE SUBTYPES AT THE INTERSECTION BETWEEN TISSUE REGENERATION AND PATHOLOGY
… susceptible to signaling manipulation and pharmacological modulation in many diseases. Based on this work, we expect to limit deleterious pericytes' functions while preserving their healthy functions.
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Inhibition of the Calcium Plateau Following In Vitro Status Epilepticus Prevents the Development of Spontaneous Recurrent Epileptiform Discharges
… after SE and demonstrates the novel finding that pharmacological modulation of [Ca2+]i following SE may inhibit epileptogenesis in vitro.
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Understanding host factors controlling intracellular killing of Mycobacterium tuberculosis
… macrophages and highlight opportunities for pharmacological modulation in host-directed TB therapy.
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Regulation of Metabolic Processes by Micrornas and Class I Histone Deacetylases
… metabolism, will provide new approaches for pharmacological intervention in obesity. Thus, the modulation of epigenetic histone modifications and microRNA functions represents a potentially powerful approach for the treatment of metabolic disorders. We show that the Ppargc1b gene, which …
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