Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 66 for “"pharmacological intervention"”.
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Neuroplasticity: induction and modulation by external stimulation and pharmacological intervention
… kortikaler Plastizität durch pharmakologische Intervention. Es wurde der Einfluss von Dopamin (DA) und Acetylcholin (ACh) auf distinkte Formen der Neuroplastizität untersucht, im speziellen der globalen und der spezifischen synaptischen Plastizität, welche jeweils durch tDCS bzw. paired …
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Pharmacological Intervention Reduces Hippocampal Hyperactivity in a Mouse Model of Psychosis
… well as in other psychiatric disorders. Current pharmacological treatment options abound in side effects, leading to poor patient adherence. Therefore, we are in need of novel mechanistic treatment targets. Prior research has identified the molecular and behavioral characteristics of a model in …
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The development of a non-pharmacological intervention for delirium management in critically ill patients
… mortality and morbidity. Multicomponent non-pharmacological interventions are beneficial in the prevention and treatment of delirium in older hospitalised patients however, there is a lack of evidence for their efficacy in critically ill patients. The studies in this thesis investigate which …
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Osteoarthritis in women living in Cape Town: prevalence, characteristics, and the effects of a non-pharmacological intervention
… to be able to plan and implement effective nonpharmacological management strategies to address the multidimensional health problem. To inform the development and implementation of a contextually relevant non-pharmacological intervention for women with osteoarthritis at primary health care …
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Serine Metabolism Leverages the Integrated Stress Response to Direct Stem Cell Fate During Tissue Regeneration
… regulator in this process. Utilizing dietary intervention and HFSC-specific loss-of-function studies, I demonstrate that under serine-depleted conditions HFSCs delay hair growth. Upon injury, serine-restricted HFSCs skew their fate towards epidermal re-epithelialization while concomitantly …
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The relationship between art and wellbeing in individuals living with dementia
… outlines the history of the rise of the non-pharmacological intervention movement over the last twenty years and profiles the work of influential figures who have promoted a person-centred approach to dementia care.
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Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours
… receptor tyrosine kinase MERTK as a potential pharmacological intervention in schwannomas and meningiomas. Immunofluorescence and flow cytometry demonstrated that MERTK is expressed by tumour cells and macrophages in both tumour types. Western blot indicated that protein levels of MERTK, as …
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Intermittent fasting as a therapeutic strategy for alzheimer’s disease: behavioral and molecular evidence
… fasting (IF) has emerged as a promising non-pharmacological intervention to improve brain health and mitigate neurodegenerative disease progression. Alzheimer’s disease (AD) is characterized by impaired metabolic functions that disrupt neuronal function and contribute to cognitive decline in …
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Notch Signaling Determines Lymphatic Cell Fate and Regulates Sprouting Lymphangiogenesis
… and decreased levels of VEGFR-2. Using genetic intervention of Notch signaling, we demonstrated that Notch regulates developmental sprouting lymphangiogenesis by restricting growth and sprouting of lymphatics in the murine embryonic dermis. Using pharmacological intervention of Notch signaling, …
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The Influence of Sustained CB1 Blockade During Adolescence on Breakpoints in a Progressive-ratio Paradigm
… throughout adolescence, whether because of pharmacological intervention or food-restriction, motivation was not significantly related to the level of food deprivation. Additionally, the SR-treated group ate more of a novel, palatable food than the vehicle-treated group. Finally, the …
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Characterization of neural ion regulation dysfunction during insult and evaluation of micro-opioid receptor activation during simulated ischemia in the pre-botzinger complex
… of the tissue. Finally, it investigates if pharmacological intervention can attenuate some of the deleterious ion flux seen in different pathologies. The accumulation of ions in the extracellular fluid affects the use of dielectric spectroscopy to analyze the system. To attenuate this …
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A computational and experimental study of HER2-signaling effects on cellular migration and proliferation
… in receptor expression, ligand treatment, and pharmacological intervention.
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Prosthetic Treatment of Patients with a Strong Nausea and Vomiting Reflex // Протетично лечение на пациенти със силен рефлекс на гадене и повръщане
… many management techniques from psychological intervention, prosthetic intervention, surgical intervention, pharmacological intervention to the scope of non-traditional medicine acupuncture and acupressure. But it turns out that neither of them is superior to another, and often a combination of …
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An investigation into the nature and prevalence of musculoskeletal conditions among women attending a community clinic, and the effectiveness of an intervention programme for these patients
… the process of developing and testing a non-pharmacological biopsychosocial intervention programme which included exercise and health education for women with musculoskeletal conditions attending a clinic in a poorly resourced area of the Free State Province in South Africa. To inform the …
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Neurobiologically-motivated treatments for post-traumatic stress disorder in an animal model
… chapter of this thesis describes a non-pharmacological intervention to enhance extinction of learned fear. In this work, optimization of extinction training yields resistance to spontaneous recovery of fear and demonstrates a weakening of potentiated synapses in the amygdala after …
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A Sensory-Based Program to Enhance Occupational Performance for Dementia
… independence and quality of life. Sensory based interventions, such as drumming groups, have been hypothesized to be a non-pharmacological intervention for individuals with dementia. The purpose of this study was to analyze the effects of a sensory based intervention program, in this case …
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Unbiased global proteomic profiling of patient-derived meningiomas of all grades to identify molecular signatures of differentially expressed proteins and phosphoproteins.
… resection remains the main therapeutic option as pharmacological intervention is still hampered by the poor knowledge of the molecular signature of these tumours. In order to elucidate the proteomic profiling of meningiomas and identify proteins involved in their pathogenesis, we completed a …
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Combinatorial Modulation of Multiple Signaling Pathways to Gain Therapeutic Response in Breast and Prostate Cell Carcinomas
Our laboratory is primarily interested in novel pharmacological intervention of cell proliferation and survival pathways expressed in various types of cancer. These cyto-protective pathways can be activated in response to growth factor stimulation, toxic insult and radiation. In our studies, we …
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Constitutive activity in orphan G protein coupled receptors
… these orphan receptors and targeting them for pharmacological intervention."--Abstract, page iii.</p>
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