Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"pharmacological effect"”.
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Pharmacological effect of MEK inhibitors on plasmodium falciparum
Malaria continues to kill up to 3 million people each year, and parasite resistance to drugs is a pressing problem. Protein kinases are now prime targets for chemotherapy in a variety of diseases such as cancer and neurodegenerative diseases, and have been proposed as potential targets for …
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Studies investigating the impact of select genotypes on the pharmacological effect of fenofibrate
… outcomes from clinical trials that tested the effect of combining statins and fenofibrate, posed a challenge in using this antidyslipidemic medication. One significant challenge of using fenofibrate is the high inter-subject variability in lipid response, which can range from -82 to 132% for …
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Improved delivery of molecularly targeted agents upon modulation of multidrug resistance efflux proteins at mouse blood brain barrier
… modulators which could also impart a synergistic pharmacological effect in the treatment regimen. Erlotinib, canertinib, everolimus and temsirolimus were screened as potential modulators of P-gp and Bcrp1 activity. The fact that these drugs inhibit a different class of receptor population than …
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Assessment of sex differences and amphetamine on schedule-induced polydipsia
… drugs abused in the United States. Its major pharmacological effect is to increase synaptic dopamine levels in the mesolimbic reward pathway, which in turn causes behavioral effects in animals, and subjective effects in humans. These reinforcing properties of AMPH trigger very strong levels of …
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Aldehyde dehydrogenases (ALDH) expression in cancer tissues as potential pharmacological targets for therapeutic intervention. Probing ALDH expression and function in 2D- and 3D-cultured cancer cell lines
… was found not to be involved in inhibiting the pharmacological effect or causing resistance to different cytotoxic and molecularly targeted anticancer drugs. To unravel the functional role of ALDH7A1, 9 compounds obtained from a virtual screening of 24,000 compounds from the Maybridge collection …
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Aldehyde dehydrogenases (ALDH) expression in cancer tissues as potential pharmacological targets for therapeutic intervention. Probing ALDH expression and function in 2D- and 3D-cultured cancer cell lines
… was found not to be involved in inhibiting the pharmacological effect or causing resistance to different cytotoxic and molecularly targeted anticancer drugs. To unravel the functional role of ALDH7A1, 9 compounds obtained from a virtual screening of 24,000 compounds from the Maybridge collection …
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Development and application of bioorthogonal palladium- labile derivatives of cytotoxic pyrimidine analogues
… rapidly causing a plethora of undesirable side effects. One rising and promising therapeutic strategy is the development of prodrugs. Prodrugs are derivatives of the pharmaceutically active drugs but require an enzymatic or biochemical transformation within a certain biological space in order …
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Nucleic acid clamp-mediated transcriptional and translational modulation of oncogenes via the stabilization of G-quadruplexes
… NRAS expression has been demonstrated to be an effective approach to induce apoptosis of lymphoma and breast cancer, and melanoma, respectively. Targeting and stabilizing G4 structures formed in the promoter of MYC and 5’-UTR of NRAS has been shown effective at silencing their expression. In …
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Gene regulation and hypertroipc responses in age-matched control and STZ-treated rats
… (p c0.05). The study also investigated the pharmacological effect of either digoxin or captopril, at a dose of 10 3 M, on the force of contraction of isolated healthy age-matched control intact perfused hearts. The results show that the cardiac glycoside, digoxin evoked a small increase in …
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Study on the effects of bitter taste receptor on the rat pulmonary artery
… perception. TAS2R agonists exert vasorelaxant effects in vascular smooth muscle from guinea pig, mouse and humans. We hypothesis that bitter taste agonists could modulate the pulmonary artery vascular tone. The mechanisms of action of bitter taste agonists, which are used to investigate the …
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Reasons for use and disclosure of complementary medicine by people with haemoglobinopathy
… Phase 2 showed the participants wanted safe and effective treatment to manage and cure the primary illness and co-morbidities. Phase 2 also indicated that CAM was used, at times in lieu of biomedicine, to prevent illnesses and to enhance quality of life (QoL) and to increase life expectancy. …
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Nasal delivery of peptides using powder carriers based on starch/poly(acrylic acid)
… to mucosal damage. The possible toxicological effects after multiple administration of the powders SD 25/75 and (SD 25/75)/CaCO3 90/10 were evaluated using a non-invasive washing technique in rabbits and using a mucosal irritation assay on slugs. Both powder formulations induced mucosal damage …