Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 32 for “"pharmacokinetic model"”.
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Development of Fractional Trigonometry and an Application of Fractional Calculus to Pharmacokinetic Model
… an application of fractional calculus to pharmacokinetic model, which is used to study the drug concentration in the body.</p>
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Development and Evaluation of a Physiologically Based Pharmacokinetic Model of Fentanyl in Dogs
… of the bioequivalence analysis indicated the model was not equivalent. The model was examined using time averaged inputs of tissue blood flows and using stepped changes in tissue blood flow representing measured changes in individual experimental subjects. Analysis of partial areas under the …
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Green's Functions of Discrete Fractional Calculus Boundary Value Problems and an Application of Discrete Fractional Calculus to a Pharmacokinetic Model
… of fractional difference equations, and to model problems in pharmacokinetics. We claim that the discrete fractional calculus yields the best prediction performance compared to the continuous fractional calculus in the application of a one-compartmental model of drug concentration. In …
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Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia
… be cured by drugs. It is therefore an important model upon which concepts of chemotherapy in other malignancies have been developed. Methotrexate is a major component of most contemporary childhood ALL treatment protocols. The main objectives of this thesis were to investigate how methotrexate …
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Improved mehtods and reagents for pretargeted radioimmunotherapy of cancer
… radioimmunotherapy (RIT) by decoupling the pharmacokinetics of the targeting agent and the radioisotope. In order to improve upon PRIT, we have considered variables such as treatment setting and methodology, the transport and clearance characteristics of targeting agents, and the …
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Optimization of 1st-line antituberculosis dosing regimens using a population pharmacokinetic approach: food effects, drug combinations and pharmacological effects
… dosing regimens using a population pharmacokinetic approach, quantify food effects, drug combinations and pharmacological effects. The population pharmacokinetics of rifampicin, isoniazid and pyrazinamide in 76 children with tuberculosis were described using a population …
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Dynamic energy budgets and bioaccumulation : a model for marine mammals and marine mammal populations
… and lactation. Dynamic energy budget (DEB) models for energy assimilation and utilization, coupled with pharmacokinetic models that calculate distribution of toxicants in individuals, can help investigate the vulnerability. In this dissertation I develop the first individual DEB model …
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Dynamic energy budgets and bioaccumulation : a model for marine mammals and marine mammal populations
… and lactation. Dynamic energy budget (DEB) models for energy assimilation and utilization, coupled with pharmacokinetic models that calculate distribution of toxicants in individuals, can help investigate the vulnerability. In this dissertation I develop the first individual DEB model …
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Mathematical Models of Immune Responses to Infectious Diseases
… HPV co-infection, ii) A germinal center dynamics model, iii) A study of monoclonal antibody therapy. We predict that the condition leading to HPV persistence during HIV/HPV co-infection is the permissive immune environment created by HIV, rather than the direct HIV/HPV interaction. In the second …
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In Vivo Fluorometric Assessment of the Skin Microcirculation
A tissue uptake model was developed to describe the fluorescein dermofluorometer signal in terms of the local blood flow and capillary permeability. The fluorescein signal is characterized by a wash-in time constant dependent on both the blood flow and permeability. Under flow-limited conditions …
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Investigating the sources and magnitude of human exposure to halogenated organic pollutants using advanced methods for environmental analysis.
… colon-enhanced physiologically based extraction model was developed and applied for the first time to study the bioaccessibility of target BFRs from human GIT. Exposure via dust ingestion, but not diet, correlated significantly (p<0.01) with ΣHBCDs in serum of 16 adults. The levels of target BFRs …
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Sublingual drug delivery: In vitro-in vivo correlation
… vivo studies and establish a correlation. Five model drugs possessing diverse physicochemical properties and New Zealand White rabbits were used for these studies. Comparison of time course of absorption revealed a significant difference in time lag between in vivo (less than 5 min) and in vitro …
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Unravelling Variability in Antidepressant Outcomes using Pharmacogenetic and Pharmacokinetic Strategies
… depression. The second study focused on pharmacokinetic factors, leveraging data from the IRL-GRey study (N = 325), where older adults with depression were treated with venlafaxine (VEN) for 12 weeks. We adapted and improved a population pharmacokinetic model for VEN and its active …
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Pharmacometric modeling and simulation of ranitidine In human gastric acid secretion.
… new methodologies to develop an appropriate model to simulate the human gastric acid system. A pharmacometric approach places strong statistical and mathematical interpretation to characterize pharmacokinetic and pharmacodynamic behavior and to identify the patient's prognostic factors that …
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Pharmacokinetics of local growth factor delivery in myocardial tissue
… fibroblast growth factor (FGF-2) were chosen as model growth factor because of their potency of inducing endothelial mitosis and angiogenesis invitro. The "effective" diffusivity and partition coefficient of radiolabeled EGF and FGF-2 in rat myocardium were obtained with a diffusion cell in …
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Beta-lactam antimicrobial dosing optimization in obese patients compared to non-obese patients using population pharmacokinetic/pharmacodynamic approach
… problem and has been associated with altered pharmacokinetics and pharmacodynamics of many drugs. However, little is known regarding the effect of obesity on the pharmacokinetics and pharmacodynamics of many broad-spectrum, beta-lactam antibiotics such as piperacillin/tazobactam, meropenem, …
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Development of a PBPK-based health risk assessment framework for exposure to cerium, gold, silver and titanium engineered nanoparticles
… study managed to apply a physiologically based pharmacokinetic model for ceria nanoparticles to determine biokinetics of ceria nanoparticles, establish whether physiologically based pharmacokinetic models are a good risk assessment tool for ceria, gold, silver and titanium nanoparticles, …
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Population/ Nonlinear mixed-effects modelling of pharmacokinetics and pharmacodynamics of tuberculosis treatment
The pharmacokinetics of rifampicin, isoniazid, pyrazinamide and ethambutol in TB/HIV coinfected patients recruited in two phase III clinical trials (61 patients in TB-HAART and 222 patients in RAFA study) were described using nonlinear mixed-effects modelling. Concentration-time data for rifampicin …
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