Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"pharmacogenomic"”.
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Towards implementation of pharmacogenomic-guided medicines optimisation for older patients in secondary care
This research explores the potential of pharmacogenomic (PGx)-guided care for older patients in secondary care. Using a mixed methods approach, the study demonstrates the efficacy of PGx-guided care for patients aged 65 and above, identifies behaviour change techniques for healthcare professionals …
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Towards implementation of pharmacogenomic-guided medicines optimisation for older patients in secondary care
This research explores the potential of pharmacogenomic (PGx)-guided care for older patients in secondary care. Using a mixed methods approach, the study demonstrates the efficacy of PGx-guided care for patients aged 65 and above, identifies behaviour change techniques for healthcare professionals …
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Exploring Barriers to the Adoption of Pharmacogenomic Technology in the Clinical Setting by Clinical Healthcare Providers
… Personalized medicine and more specifically, pharmacogenomic technology have offered new tools for healthcare providers to use to increase the efficacy, safety, and cost-effectiveness of care. However, these tools are not being utilized to their predicted extent in the clinical setting. This …
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Conception and Implementation of a Pharmacogenomic Plausibility Check: Integrating Molecular Data to Optimize Established Drug Therapy Safety Workflows
… expansion in the accessibility of high-quality pharmacogenomic knowledge and research exploring its advantages. The increasing availability of freely accessible information on drug-gene interactions enables the use of such data for a plausibility check during the prescribing process, thereby …
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Facilitating Pharmacogenetic Association Studies Using an Extensible Genotype Information Management System
… management system that provides storage for pharmacogenomic information including genotypic, phenotypic and resequencing data. The system provides an integrated solution for the acquisition, organization, storage, retrieval and analysis of pharmacogenomic data and offers a platform for genome …
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Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort
To date, surgery is the mainstay treatment for HNPCC. Adjuvant chemotherapy and radiotherapy are often used to reduce systemic and locoregional recurrence, respectively, after curative surgical resection. The main chemotherapeutic agent is 5-Fluoroucacil (5-FU). Studies have attempted to elucidate …
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A molecular approach to precision medicine in South African children with Epilepsy: towards a genetics-based diagnostic service for Epilepsy
… criteria. All 40 probands were tested with two pharmacogenomic arrays, one generalised array, the Veridose® Core Panel produced by Agena Bioscience (San Diego, USA), and one custom-designed anti-seizure medication-specific SNV array targeting eight SNVs across six different genes. Results: Three …
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Pharmacogenetics : ethics and public policy
… be so direct. Moreover, challenges for future pharmacogenomics and its translation into personalized drug development need to be addressed. Pharmacogenetics’ applications include refining and improving the safety and efficacy of medicines by genotype-based prediction of responses. It also …
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Genetic Predictors of Hyperglycemia Due to Hydrochlorothiazide Therapy
… of Responses to Antihypertensives (GERA) and Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) clinical trials. No SNP reached the <em>a priori</em> defined threshold of statistical significance (p<5x10<sup>-8</sup>). We detected 50 SNPs in 9 genomic regions with suggestive …
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Application of Informatics Tools to Facilitate the Practice of Precision Medicine with Genomic Testing and Clinical Data
… pertaining to the gene selection practices of pharmacogenomic (PGx) tests effectively communicated large amounts of information into concise heatmaps. After a thorough search identifying potential PGx tests, their detection rates were assessed based on their gene targets and the genomic …
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Making augmented human intelligence in medicine practical: A case study of treating major depressive disorder
… depression severity assessments augmented with pharmacogenomic measures can accurately predict remission of depressive symptoms using supervised learning. Finally, probabilistic graphs provide early and easily interpretable prognoses at the “right time” to a psychiatrist by accounting for …
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Genetic Predictors of Metabolic Side Effects of Diuretic Therapy
… to HCTZ from two different clinical trials: the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) and the Genetic Epidemiology of Responses to Antihypertensive (GERA) studies. Two SNPs (rs12279250 and rs4319515 (r2=0.73)), located at 11p15.1 in the NELL1 gene, achieved genome-wide …
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Clinical Drug-Gene and Drug-Drug-Gene Interactions for the Most Commonly Used Chronic Drugs in the UK
… the value of using large population datasets for pharmacogenomic discovery and has identified novel findings that may impact on clinical care.
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Associations of genetic variants in ABCB1, ABCG2, CYP3A4, CYP3A5, and SLCO1B1 with statin-associated muscle symptom (SAMS) in South African populations
… knowledge of SAMS in a population with limited pharmacogenomic data, potentially informing personalized statin therapy. Key Words: dyslipidaemia, SAMS, pharmacogenetics, ABCB1, ABCG2, SLCO1B1, South African
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Συγκριτική μελέτη και αξιολόγηση της υιοθέτησης της γενετικής και της φαρμακογονιδιωματικής στην ελληνική κοινωνία
Η υπηρεσία γενετικής και φαρμακογονιδιωματικής ανάλυσης έχει τη δυνατότητα να εξασφαλίσει τη βέλτιστη θεραπεία και την καλύτερη χρήση φαρμακευτικής αγωγής σε έναν αυξανόμενο αριθμό ασθενειών, ενώ η εξατομικευμένη και η γονιδιωματική ιατρική θα γίνουν όλο και πιο χρήσιμες με αποτέλεσμα τη σταδιακή …
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Advancing precision medicine: harnessing data from diverse sources and individuals to predict medication efficacy and safety.
… East Asian subgroup, revealed unique pharmacogenomic (PGx) traits impacting their warfarin dosing. Analyzing data from two Hmong cohorts (n=236 and n=198), we found significantly higher CYP2C9*3 allele frequencies (18.9% vs. 3.0%) and lower predicted warfarin maintenance doses (19.8 …
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Sensibilidad a la Heparina, reversión y sangrado en revascularización miocárdica: estudio de cohorte, Fundación Cardioinfantil, 2019
Introducción: La revascularización miocárdica es la cirugía cardíaca más frecuente, la sensibilidad a heparina y los efectos anticoagulantes de la protamina están relacionados con el sangrado peri-operatorio. Objetivo: Establecer la relación protamina-heparina y el sangrado postoperatorio según la …