Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 117 for “"pharmacodynamic"”.
-
Design and Analysis of Pharmacokinetic and Pharmacodynamic Trials
Pharmacokinetic (PK) and Pharmacodynamic (PD) experiments play an important role in drug development. Statistical design determines the treatment allocation and time points for taking PK/PD measurements. A good design will reduce the cost and suffering of humans/animals used in the experiment and …
-
Cell physiology based pharmacodynamic modeling of antimicrobial drug combinations
… robust against variation in the growth phase and pharmacodynamic endpoint definition, but sensitive to a change in the experimental duration. Furthermore, the developed approach included a detailed representation of the bacterial cell-cycle. We used this representation to describe septation …
-
Population pharmacokinetic and pharmacodynamic modelling to improve tuberculosis treatment
… pregnancy. We assessed the pharmacokinetics and pharmacodynamics of pretomanid, clofazimine, and linezolid in African tuberculosis patients. Reassuringly, we found no significant pregnancy effect on the exposure of these antituberculosis agents, thus confirming the suitability of current doses in …
-
Pharmacokinetic and Pharmacodynamic Modelling to Advance Perioperative Anaesthesia and Analgesia
… and alongside others. Pharmacokinetic (PK) and pharmacodynamic (PD) models summarise complex drug relationships so they may be better understood and capitalised on. I report my investigations into using PKPD models to describe combined drug responses for applications in anaesthesia. I …
-
UNIQUE PHARMACODYNAMIC PROFILE OF METHYLPHENIDATE: SELF-ADMINISTRATION-INDUCED DOPAMINE SYSTEM ALTERATIONS
Methylphenidate (MPH), the active compound in the medication Ritalin, is commonly diverted for off-label use. It is abused at high rates in both the adolescent and adult population; however, until recently, the neurochemical effects of MPH abuse had not been explored in depth. Pharmacologically MPH …
-
Clinical pharmacology of camptothecins: Model based population pharmacokinetic and pharmacodynamic analysis.
… Model based population pharmacokinetic and pharmacodynamic analysis.
-
Pharmacokinetic and pharmacodynamic studies of mycophenolic acid in renal transplant recipients
… purpose was to identify the pharmacokinetic and pharmacodynamic profiles, to establish the PK-PD relationship of MPA and to quantify average population pharmacokinetic and pharmacodynamic parameters and evaluate the influence covariates on the PK-PD variability.Stable renal transplant patients …
-
Pharmacokinectic and pharmacodynamic aspects of cocaine and its interaction with ethanol
… aspects of cocaine in pharmacokinetics and pharmacodynamics including: physiologically based-pharmacokinetics modeling; the influence of ethanol on cocaine disposition. Further, cocaine and cocaethylene (CE) were compared using pharmacokinetic-pharmacodynamic (PK-PD) models. Lastly, PK-PD …
-
A Comparative Pharmacodynamic Study of Six Insecticides in Eight Insect Species
Made available in DSpace on 2014-12-14T07:03:55Z (GMT). No. of bitstreams: 1 7616107.pdf: 4436825 bytes, checksum: 55d398d9138d1e3b6557ecc59c883cec (MD5) Previous issue date: 1976
-
Pharmacodynamic evaluation of beta-blockade associated with atenolol in healthy dogs
Objective: Dosing intervals of 12 and 24 hours for atenolol have been recommended, but an evidentiary basis is lacking. To test the hypothesis that repeated, once-daily oral administration of atenolol attenuates the heart rate response to isoproterenol for 24 hours, we performed a double-blind, …
-
Pharmacokinetic and Pharmacodynamic Studies of a Novel Spectinamide Series of Antituberculosis Agents
… application of an iterative pharmacokinetics and pharmacodynamics (PK/PD) guided approach would facilitate the optimization of these lead compounds suitable for further development.</p> <p>A series of <em>in vitro </em>experiments including parallel artificial membrane permeability assay (PAMPA), …
-
PRECLINICAL PHARMACOKINETIC AND PHARMACODYNAMIC EVALUATION OF NEW ANTICANCER AGENTS FOR BRAIN TUMOR CHEMOTHERAPY
… investigation of the pharmacokinetics (PKs) and pharmacodynamics (PDs) of novel agents in the preclinical stage plays a pivotal role in drug development that could be applied to guide clinical trials. The main goal of the project was to undertake comprehensive PK and PD evaluation of new agents …
-
Comparative safety, pharmacokinetic and pharmacodynamic evaluation of three oral selenium compounds in cancer patients
… tolerability and pharmacokinetic (PK) and pharmacodynamic (PD) profiles of sodium selenite (SS), Se-methylselenocysteine (MSC) and seleno-l-methionine (SLM) were compared in patients with chronic lymphocytic leukaemia (CLL) and a cohort of patients with metastatic solid cancers. Patients …
-
Methods to Improve Virtual Screening of Potential Drug Leads for Specific Pharmacodynamic and Toxicological Properties
… of these strategies was evaluated using pharmacodynamic data sets such as lymphocyte-specific protein tyrosine kinase inhibitors (Lck) and phosphoinositide 3-kinase inhibitors (PI3K). Further investigated were toxicological data sets such as eye and skin irritation, compounds that produce …
-
In Vitro and in Vivo Pharmacodynamic Characterization of the Novel Plasma Kallikrein Inhibitor Pf-04886847
Plasma kallikrein plays an important role in the pathogenesis of inflammation and thrombosis. Kallikrein cleaves high molecular weight kininogen (HK) to liberate the potent pro-inflammatory peptide bradykinin (BK). BK upon activation of its constitutive B2 receptors on endothelial cells leads to an …
-
Regulation of cAMP-Dependent Gene Expression in Airway Epithelial Cells: A Transcriptional and Pharmacodynamic Analysis
… GSK 256066, by a pent-1-yn-1ylbenzene spacer. Pharmacodynamic studies established that the PDE4 inhibitor pharmacophore produced a 35.5-fold increase in affinity for the b2-adrenoceptor relative to the monofunctional parent compound in the absence of any change in efficacy. However, this was …
-
Characterizing population pharmacokinetic/pharmacodynamic relationships in pulmonary tuberculosis infected adults using nonlinear mixed effects modelling
This pharmacokinetic sub-study was nested within the phase-III OFLOTUB study investigating the shortening of tuberculosis treatment. A total of 343 adults enrolled in Benin, Guinea, Senegal, and South Africa were randomized to receive rifampicin, isoniazid, pyrazinamide, and ethambutol in the …
Page 1 of 6