Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"pharmaceutical compounds"”.
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Detection and imaging of pharmaceutical compounds in skin by MALDI-MS.
… has been employed for the detection of pharmaceutical compounds and also mass spectrometric 'images' have been produced which show the spatial distribution of peptides, proteins and drugs in tissue.In this thesis, a programme of method development for the detection and imaging of …
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Thin layer chromatography-matrix assisted laser desorption ionisation-mass spectrometry of pharmaceutical compounds.
… (TLC) is of great importance for the pharmaceutical industry as a simple, quick, and low cost analytical method. Considerable effort has been made over the past decades to combine the simplicity of TLC with the selectivity and sensitivity of mass spectrometry (MS) detection. In the …
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Supercritical fluid spray processes for microencapsulation and formation of submicron aqueous dispersions of pharmaceutical compounds
… examined to produce stable particles of various pharmaceutical compounds. PCA is an antisolvent precipitation technique where an organic solution of drug + polymer in solvent is atomized (sprayed) into supercritical (SC) CO₂. Upon liquid mixing, the solute materials precipitate to form …
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Investigating human pharmaceutical compounds present in municipal and hospital wastewaters and options for their removal
Pharmaceutical compounds comprise a wide range of substances that are consumed in large quantities by modern societies and are generally released into local sewer networks through excretion. This research aimed to identify the factors affecting the removal efficiencies of these compounds in …
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Supercritical fluid extraction as a sample preparation technique for the isolation of polar pharmaceutical compounds
… problems when applying this technique to polar compounds. The objective of this research was to expand the applicability of SFE to include polar compounds. The first phase of this research investigated "inverse SFE", which is the selective extraction of the matrix while leaving behind the target …
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Transport of proteins, biopharmaceuticals and small pharmaceutical compounds into normal and injured cartilage by Sangwon Byun.
… the uptake and binding of proteins and biopharmaceuticals in normal articular cartilage and have compared the results to those in cartilage subjected to mechanical injury and pro-inflammatory cytokines. We studied equilibrium partitioning and non-equilibrium transport into cartilage of …
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Contributions to method development in capillary electrophoresis and supercritical fluid chromatography for the analysis of pharmaceutical compounds
Univerzita Karlova, Farmaceutická fakulta v Hradci Králové Školicí pracoviště Katedra analytické chemie Doktorský studijní program Farmaceutická analýza Kandidátka / kandidát Mgr. Petra Riasová Školitelka / školitel doc. RNDr. Miroslav Polášek, CSc. Prof. dr. Debby Mangelings Prof. dr. Yvan Vander …
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Analysis of pharmaceutical compounds in WWTP of the Region of Murcia and its ecotoxicological effects in the Guadalentín River
El agua se puede considerar como el bien más preciado para la vida ya que es completamente imprescindible para su desarrollo. El material es muy abundante pero es muy escaso con las cualidades necesarias para el equilibrio del medio ambiente y para el consumo humano. Esta escasez se debe …
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Fingerprinting analysis of non-crystalline pharmaceutical compounds using high energy X-rays and the total scattering pair distribution function
… due to the low solubilities of many active pharmaceutical ingredients (APIs), is increasingly a barrier for treatments to be administered using tablet or capsule formulations and one of the main challenges facing the pharmaceutical industry. Non-crystalline phases such as the amorphous and …
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The Investigation of Primary and Secondary Modifiers in the Extraction and Separation of Neutral and Ionic Pharmaceutical Compounds with Pure and Modified Carbon Dioxide
… method was developed. The extraction of ionic compounds with carbon dioxide may be difficult due to the high polarity of the compounds. In the third phase of this research, the addition of ion-pairing additives to the matrix in hopes of forming an ion-pair complex of reduced analyte polarity …
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Understanding the fate of active pharmaceutical compounds in waters receiving poorly or untreated wastewater for the development of a dedicated environmental risk assessment approach
… increasing consumption and production of active pharmaceutical ingredients (APIs) is of a growing environmental concern. The inherently biological activity of APIs creates a concern of potential ecotoxicological effects even at very low concentrations. Such risk is particularly exacerbated in low …
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Investigation of occurrence, elimination and degradation of pharmaceutical and personal care products in drinking water using liquid chromatography-tandem mass spectrometry
<p>"Pharmaceutical and personal care products have benefited humans and animals around the world. However, their presence in natural and treated water system as emerging contaminates may have potentially adverse effects on the aquatic environment and cause development of bacterial resistance. In …
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Synthesis of Deoxysugars through Manganese-promoted Redox Isomerization
… in many bioactive natural products and pharmaceutical compounds. Many synthetic routes towards deoxysugars rely on protecting groups to achieve selective outcomes. Here we report a concise synthetic strategy to access a diverse set of 2- and 4-deoxysugars using a Mn-promoted redox …
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Soil and Wastewater Properties that Influence the Uptake of Anti(retro)viral Pharmaceuticals in Plants
… evaluated the fate of anti(retro)viral (ARVDs) pharmaceutical compounds in the wastewater-soil-plant-human continuum. Wastewater frequently contains pharmaceutical micropollutants. A cause to worry is the potential uptake and bioaccumulation of these biologically active contaminants via the …
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Development of a Novel 3-Dimensional Testicular Organoid Model for the Study of Human Spermatogenesis and Gonadotoxicity In Vitro
… gonadotoxicity of environmental agents and pharmaceutical compounds rely heavily on the use of animal data. However, current gold standard in vivo functional assays in animals are limited in their human predictive capacity, and existing human in vitro models of testicular toxicity do not …
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The use of MALDI-MS for imaging drug disposition in respiratory disease models.
… applied to monitoring the distribution of pharmaceutical compounds in tissues. The main aim of the work reported in this thesis is to monitor the distribution of respiratory compounds in the lungs following inhaled delivery.Glucocorticoids that contain multiple carbonyl functionalities are …
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Supramolecular modification of selected antiretroviral drugs
… This, along with the fact that many of these pharmaceutical compounds possess potential hydrogen bond donor and acceptor functionalities, makes them ideal candidates for attempted supramolecular derivatisation. The primary objective of this study was to carry out cocrystal screening and …
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Design of a rapid, continuous, small-scale device for creating dry powders from concentrated suspensions containing active pharmaceutical ingredients
Current methods of producing pharmaceutical compounds are large batch processes. The minimum time-to-patient for drug manufacturing is approximately 100 days. Using a continuous manufacturing process, the time-to-patient could be reduced to less than ten days. The scope of this paper encompasses …
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Biochemical studies of targeted and bimodal analogues of the natural anticancer compounds combretastatin A-4 and illudin M
… scaffolds. The cytotoxicity of promising pharmaceutical compounds was tested on various cells of neural and/or cancerous origin, monitoring their specificity, re-growth retardation and mechanism of apoptosis induction. The proposed drug uptake was analysed using specific inhibitors to …
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