Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 34 for “"phagocyte"”.
-
Mononuclear phagocyte activation and its role in HIV-1 pathogenesis
… focused on the relationships between mononuclear phagocyte activation and HIV-1 pathogenesis, both <i>in vitro</i> using model systems and <i>in vivo</i> in African patients with AIDS, Using a monocyte-derived macrophage (MDM) model of Ml and M2a polarization, I found that activation transiently …
-
A phagocyte-specific Irf8 gene enhancer establishes early conventional dendritic cell commitment
… is strictly hierarchically organized. Here, the phagocyte lineages are a very heterogeneous cell compartment with specialized functions in innate immunity and induction of adaptive immune responses. Their generation from a common precursor must be tightly controlled. Interference within lineage …
-
Dosage Window of Selenium on Human Natural Killer Cytotoxicity and Neutrophilmediated Chemiluminescence
… on natural killer (NK)-mediated cytotoxicity and phagocyte chemiluminescence (CL) were examined. NK-mediated cytotoxicity and phagocyte CL were observed to be affected by added selenite. These changes generally included augmentation and suppression of both neutrophil CL and NK-mediated …
-
Optimization and Validation of the Derivation and Use of HoxB8 Transgenic Murine Phagocytes in In Vitro Studies
… the validation that conditionally immortalized phagocyte progenitors are comparable to those obtained through current methods which will ensure that this system can be used to advance research in the understudied area of phagocyte biology. To do this I finished a comprehensive tool/resource …
-
Somatolactogenic hormones and interferon-gamma as regulators of neutrophil activation
… (GH) and prolactin (PRL), as well as the classic phagocyte activator, interferon-gamma (IFN-$\gamma$), in activating polymorphonulear neutrophils (PMN) from pigs, cows, rats and humans to kill Escherichia coli and secrete superoxide anion (O$\sb2\sp-$) after stimulation with phorbol myristate …
-
CHARACTERIZATION OF IMMUNE RESPONSE IN EXPERIMENTAL MOUSE MODELS
… fields were investigated: Study I – Mononuclear phagocyte system cells in murine healthy organs and selected pathological conditions. Study II – Sex-dependent modulation of inflammation in a murine caerulein-induced acute pancreatitis model. Study III – Comparison between two methods of digital …
-
The Effect of Glucose on Neutrophilic Phagocytosis
… the second counted the number of bacteria per phagocyte. Statistically no difference was noted between the two methods.</p>
-
Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammation
… while decreasing the burden of mononuclear phagocyte (MP) infiltration and secondary CNS damage. Mechanistically, the anti-inflammatory activity of NSCs arises in response to succinate released by inflammatory MPs, which activates succinate receptor 1 (SUCNR1)/GPR91 on NSCs, thus initiating …
-
Mechanisms Of Cytokine-Induced Metabolic Dysfunction Of The Pancreatic Beta-Cell
… damage are only partially understood. Phagocyte-like NADPH oxidase [NOX2] has been shown to play regulatory roles in the metabolic dysfunction of the islet â-cell under the duress of glucolipotoxic conditions and exposure to proinflammatory cytokines. However, the precise mechanisms …
-
Mechanisms underlying neural circuit remodeling in Toxoplasma gondii infection
… infection triggers microglia and monocytes (i.e. phagocytes) to target, ensheath, and remove perisomatic inhibitory synapses on neuronal somata indiscriminately, or whether specificity exists in this type of circuit remodeling, remained unclear. Through a comprehensive assessment of phagocyte …
-
Differential Screening in Immunodeficient Mice Reveals Bacterial Enzymes With Unexpected Roles in Host-Pathogen Interactions
… enzyme that participates in resistance to phagocyte oxidase. The Mtb enzymes suggest novel pathways for countering IFN-y-dependent immune mechanisms other than NOS2. Analysis of the sequence of the S. typhimurium enzyme suggests the existence in prokaryotes of an alternative signaling …
-
In Vitro Evidence For A Spleen-Derived Macrophage Suppressor Factor
… reduced the number of intracellular Listeria per phagocyte by 33 percent. This result correlates well with the results of in vivo assays comparing normal and splenectomized mouse PEC activity. When NMP was separated by pressure ultrafiltration, the low (less than 10,000) MW fraction suppressed …
-
Oral uptake and distribution of microspheres
… in greatest numbers within the Mononuclear phagocyte system tissues after gavage. Again translocation was rapid. The ability of test particles to leave the intestinal lumen and access systemic compartments was found to be highly dependent on their size and hydrophobicity, determined by …
-
Binding of Mycobacterium tuberculosis to complement receptor type 3 expressed in mammalian cells : dependence on serum opsonins
Nonopsonic invasion of mononuclear phagocytes by Mycobacterium tuberculosis (M. tb.) is likely important in the establishment of a primary infection in the lung. M. tb. binds to a variety of phagocyte receptors, of which the mannose receptor and the complement receptor type 3 (CR3) may support …
-
Novel Mechanisms of Antigen Processing That Enhance Bcg Vaccine Efficacy
… pH regulation including vacuolar proton ATPase, phagocyte oxidase and superoxide dismutase (SOD) secretion from BCG vaccine affect antigen processing within phagosomes. These studies led to the discovery that a mutant of BCG vaccine which lacked SOD was a better vaccine. Subsequently, the …
-
The production and gene polymorphisms of tumor necrosis factor-alpha in patients with tuberculosis in the Vhembe District, Limpopo Province
… the production of cytokines via the mononuclear phagocyte system. Although mutations in immune-related genes may directly impact a host’s ability to control the infection when exposed to M.tb, the pro-inflammatory cytokine Tumor Necrosis Factor- α is crucial in host defence against TB and …
-
Ehrlichia chaffeensis TRP32 is a Nucleomodulin that Regulates Host Gene Expression and Post-Translational Modifications Determine its Localization and Function
… bacterium that reprograms the mononuclear phagocyte through diverse effector-host interactions to modulate numerous host cell processes, including transcription. Previously, we reported that E. chaffeensis TRP32, a type 1 secreted effector, interacts with multiple host nucleus-associated …
-
The effect of manipulating apoptotic cell uptake on their immunogenicity
… cells are cleared rapidly by professional phagocytes thus preventing the release of potentially inflammatory or immunogenic material into the surrounding environment. In addition, macrophages release immuno-suppressive cytokines such as tumour growth factor ? (TGF-?) and interleukin-10 …
Page 1 of 2