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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"phage infection"”.
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Using population dynamics to decipher phage infection
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms
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Investigations into the Phage-Host Dynamics of Streptomyces
Bacteriophage (phage) infection poses a major risk to bacteria, and as such most bacteria have evolved myriad defences to protect against it. Streptomyces bacteria are a genus of the order Actinomycetales and are characterized by their complex lifecycle and prodigious production of secondary or …
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Mechanisms of phage detection by bacterial innate immune proteins
… from their viral predators, known as bacteriophages (or phages). As a result, bacteria have evolved diverse immune mechanisms to protect themselves from phage infection, such as restriction modification, CRISPR-Cas, and abortive infection (Abi) systems. Because Abi systems function through …
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Anti-CRISPRs and CRISPR-Cas: Characterization and Biotechnology
Abstract Bacteria and phages (bacterial specific viruses) have been undergoing an evolutionary arms race for billions of years, whereby bacteria evolve mechanisms to inhibit phage infection and phages evolve mechanisms to evade bacterial defenses. Consequently, there are several mechanisms used by …
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The effect of phosphorus and nitrogen limitation on viral infection in microcystis aeruginosa NIES298 using the cyanophage Ma-LMM01
… to regulation by biotic factors, including phage infection. To address the potential role of cyanophages on the dominant species in most cHABs during nutrient-limited periods, we studied a specific host-phage system: Ma- LMM01 (phage) and <em>Microcystis aeruginosa</em> strain NIES298 …
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Rarely Acquired Type II-A CRISPR-Cas Spacers Mediate Anti-Viral Immunity Through the Targeting of a Non-Canonical PAM Sequence
… that infect prokaryotes, called bacteriophages or phages, are thought to outnumber bacteria by a ratio of 10:1 and provide a constant threat to their hosts. In response, bacteria have evolved numerous defense mechanisms, attacking all major steps of the phage infection and replication …
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Two strategies to deepen knowledge the antibiotic resistance related traits in Italian MDR Staphylococci: comparative transcriptomic of two DAP-R/DAP-S MRSA isogenic couples and CRISPR system characterization of pathogenic S. epidermidis
… been frequently implicated in endocarditis and infections of surgical implants and it seems to be the source for antibiotic resistance related gene acquisition by S. aureus. A comparative transcriptomic analysis by RNA-seq and bioinformatic of two Methicillin-Resistant S. aureus isogenic pairs, …
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Conflict between bacteriophages and a mobile genetic element in bacterial immunity
Bacteriophages (phages) are the most abundant biological entities on the planet. They are ubiquitous and numerous across the many environments bacteria are found. To combat phage predation, bacteria have evolved numerous immune strategies, so-called anti-phage defense systems. Likewise, phages …
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The role of a toxin-antitoxin system in the arms race between bacteria and phage
… face the fundamental challenge of responding to infection by pathogens. In bacteria, the need to survive predation by phages, or bacterial viruses, has driven the evolution of numerous highly sophisticated anti-phage elements, including restriction modification and CRISPR-Cas systems. These …
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Investigation of flagellotropic phage interactions with their motile host bacteria
Bacteriophages cohabit with their bacterial hosts and shape microbial communities. To initiate infection, phages use bacterial components as receptors to recognize and attach to hosts. Flagellotropic phages utilize bacterial flagella as receptors. Studies focused on uncovering mechanistic details …
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Statistically inferring the mechanisms of phage-host interactions
Bacteriophage and their hosts are locked in an age-old arms race. Successful bacteria are subject to predation, forcing the population to diversify, and phage are also quick to adapt tactics for infecting these potential hosts. Sampling of closely related bacterial strains that differ in phage …
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Generation of Memory of Infection During the CRISPR-Cas9 Immune Response
… against viral attack in prokaryotes. Upon infection, short phage sequences known as spacers integrate between CRISPR repeats and are transcribed into small RNA molecules that guide the Cas9 nuclease to the viral targets (protospacers). Streptococcus pyogenes Cas9 cleavage of the viral …
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ToxIN-mediated resistance to and cell-free production of Salmonella bacteriophages
… these limitations is the application of bacteriophage cocktails, consisting of numerous bacterial viruses which kill the target pathogen. However, the use of phages also comes with two significant drawbacks: phage resistance and manufacturing hurdles. Resistance to phages may reduce the efficacy …
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Ancient Immune Systems: Sensing and Signaling in Bacterial-Phage Conflict
… life on Earth. In the microbial world, bacteriophages (phage) are bacterial viruses and drive a continuous evolutionary arms race that has led to an extraordinary diversity of bacterial defense mechanisms [1]. These systems are thought to have provided the evolutionary foundation for numerous …
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Adaptive Mechanisms of an Estuarine Synechococcus based on Genomics, Transcriptomics, and Proteomics
… occurred after CB0101 was infected by a lytic phage. On the other hand, phage-encoded host-like proteins (hli, psbA, ThyX) were highly expressed upon phage infection. This research provides new evidence that estuarine Synechococcus like CB0101 have inherited unique genetic machinery, which …
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A Stochastic Framework to Model Extrinsic Noise in Gene Regulatory Networks
… discrete models: the cell fate of lambda phage infection of bacteria, the lactose utilization system in E. coli, and a signaling network in melanoma cells. The framework captures factors that signicantly contribute to the random decision between lysis and lysogeny as well as explains the …
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Prevention of Duchenne Muscular Dystrophy by CRISPR/Cas Therapeutic Genome Editing
… in bacteria and archaea for defending against phage infection. Recently, the CRISPR/Cas system has been applied for mammalian genome editing because it provides site-specific DNA double-stranded breaks with simplicity and precision. In this study, I demonstrate the feasibility of using …
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Biochemical and Biological Studies on the Growth of an RNA Containing Bacteriophage
<p>The growth of the RNA-containing bacteriophage f2 has been studied. DNA synthesis appears normal after phage infection. It is possible to dissociate the synthesis of viral RNA from the synthesis of DNA using thymine-less bacteria with fluorinated pyrimidines and Mitomycin C as inhibitors of DNA …
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Phage host range and definition of genes implicated in Type III toxin-antitoxin-mediated abortive infection
… threat by their viral parasites, the bacteriophages (phages) and have evolved a range of anti-phage systems to defend themselves. One of these systems is termed abortive infection (Abi) where, upon phage infection, an Abi system may be activated which initiate a bacteriostatic or bactericidal …
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Physiological roles and regulation of the cryptic prophage-encoded small protein DicB and small RNA DicF in Escherichia coli
… have been characterized, very few that are phage or prophage-encoded have been studied. This dissertation describes the roles and regulation of the sRNA DicF and small protein DicB encoded on the Qin cryptic prophage of Escherichia coli K12. Bacterial genomes harbor cryptic prophages that …
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