Global ETD Search
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Showing 1 to 2 of 2 for “"pfkelch13"”.
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New approaches for measuring fitness of Plasmodium falciparum mutations implicated in drug resistance
… chapter studies the contribution of mutations in Pfkelch13, a molecular marker of artemisinin resistance, to parasite fitness. Combining CRISPR/Cas9-based genome editing and high throughput sequencing, the impact of Pfkelch13 alleles on fitness in the context of particular strain backgrounds is …
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The influence of genetic background on drug resistance in the malaria parasite Plasmodium falciparum
… mutations, including the R539T mutation in *pfkelch13*, a gene associated with artemisinin resistance. R539T has been demonstrated to have a high fitness cost, and similar PfKelch13 mutations display fitness costs that are exacerbated when engineered into non-Southeast Asian parasites. …