Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"pfcrt"”.
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The occurence, distribution and frequency of membrane transporter resistance alleles in <i>Plasmodium falciparum</i> and their association with response and resistance to Arteminisin based combination therapy (ART) in Northern Nigeria
… chloroquine resistance transporter (<i>Pfcrt</i>), which belongs to the drug metabolite transporters; that acts by directly facilitating the efflux of chloroquine, from the digestive vacuole. The second protein associated with the multi-drug resistance, in <i>P. falciparum</i>, is the …
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Development of novel strategies to combat multidrug resistance mediated by efflux transporters and intracellular bacteria
… chloroquine resistance transporter (PfCRT) have given rise to strains unsusceptible to the aminoquionoline family of antimalarials. Using the very drug substrates, we have developed bivalent inhibitors of P-gp. Here, click chemistry has been utilized to rapidly synthesize a library of …
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The influence of genetic background on drug resistance in the malaria parasite Plasmodium falciparum
… in the Chloroquine Resistance Transporter (PfCRT). Variations in the ABC transporter *pfmdr1* modulate sensitivity to multiple antimalarials, including mefloquine and lumefantrine, popular partner drugs in first-line artemisinin combination therapies. During my PhD, I assessed a panel of …
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Glutathione metabolism of Plasmodium falciparum
… with mutations in the CQ resistance transporter (PfCRT), a membrane protein of the digestive vacuole that allows the efflux of the drug form its site of action. However, PfCRT mutations alone cannot explain the full array of phenotypes found in resistant parasites. GSH is able to degrade heme, the …
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An investigation of the mechanisms of piperaquine resistance in Plasmodium falciparum malaria
… in the chloroquine resistance transporter gene (pfcrt) and the multidrug resistant protein 1 (pfmdr1) transporter. SNPs in pfcrt have been reported to confer piperaquine resistance in the field and in vitro and our recent drug-pressure experiments provide additional evidence to support these …
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Exploring the Plasmodium falciparum Transcriptome Using Hypergeometric Analysis of Time Series (HATS)
… falciparum chloroquine resistance transporter (PfCRT), another important resistance determinant; and finally a set of parasites that had varying sensitivity to artemisinins. This analysis resulted in a rich library of high scoring genes that may merit further exploration as potential modes of …
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Korrelation von in vivo-Resistenz gegen Chloroquin mit allelischen Polymorphismen bei Plasmodium falciparum-Isolaten aus Uganda
… Vielmehr könnte dem in der Nähe gelegenen Pfcrt [Fidock et al. 2000] eine Schlüsselrolle zukommen. Ob dieses oder noch andere Kofaktoren eine Rolle spielen, müssen allerdings weitere Untersuchungen ergeben.
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Comparative and Epidemiological Genomics of Human Malaria Parasites
… I identify a specific haplotype of the pfcrt gene that displays super-resistance to chloroquine and that acts as a genetic backbone to artemisinin resistance and to multidrug resistance in general. The approach taken in this thesis is one of extracting new information from layering on …
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A pharmacokinetic and antimalarial efficacy evaluation of pyridodibemequines and their metabolites
… falciparum chloroquine resistance transporter (PfCRT) to hinder the efflux of chloroquine (CQ) from its site of action, thereby reversing CQ resistance. The parent compounds of the PDBQ series, which differ in the ortho-, meta-, and para-orientation of the dibenzylmethylamine side chain, …