Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"persulfide"”.
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Biophysical and Functional Characterization of the Persulfide Sensor CstR from Staphylococcus aureus
… sulfur of an inorganic polysulfide or organic persulfide donor to form di-, tri, and tetrasulfide bonds between two conserved cysteine residues, Cys31 and Cys60' on opposite protomers as determined by high-resolution tandem mass spectrometry. These modifications result in negative regulation of …
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Small Molecule and Macromolecular Donors of Reactive Sulfur Species: Insights into Reactivity and Therapeutic Potential
… investigate other related sulfur species (i.e. persulfides, R–SSH) for their physiological interactions with H2S and potential therapeutic efficacy. This recent interest in persulfides has stimulated a flurry of research in the field and created a new set of scientific problems to solve and …
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Synthesis of Small Molecule and Polymeric Systems for the Controlled Release of Sulfur Signaling Molecules
… reaction) to facilitate the release of a persulfide (R–SSH) from a small molecule prodrug platform as well as a separate system that releases COS/H₂S from a polymer. The self-immolative persulfide prodrug was designed to be responsive to reactive oxygen species (ROS) and demonstrates …
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Characterization of PspE, a Secreted Sulfurtransferase of Escherichia coli
… thiosulfate, which suggested that PspE1 is the persulfide form. One equivalent of cyanizable sulfur was associated with PspE1, with much less present in PspE2. Consistent with the conclusion that the single active site cysteine of PspE1 contains a persulfide sulfur was the observation that this …
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Genetic and biochemical characterization of YrkF, a novel two-domain sulfurtransferase in Bacillus subtilis
… spectrometry suggested YrkF contains a stable persulfide sulfur, whereas YrkF<sup>C15A</sup> showed no evidence of a stable persulfide sulfur and was prone to oxidation and other active site modifications. A homology model of YrkF was created using structures of a rhodanese homolog and a Ccd1 …
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Investigations of conserved structure-function relationships and enzymatic evolution
… the deprotonation of SufE C51 and facilitating persulfide transfer. Kinetic analysis of the Arg359 variants suggest a role in cysteine binding and positioning the substrate for bond cleavage. The work presented here contributes to the current understanding of the SufS mechanism and may be more …
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Degradable Polymers for the Controlled Delivery of Bioactive Small Molecules
… (H2S). H2S is featured in this work, as well as persulfides (RSSH), which also have similar functions to H2S (e.g., angiogenesis) and are the presumed signaling products of H2S but are less studied. Other compounds that are considered potential gasotransmitters include methane, sulfur dioxide, …