Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"persister"”.
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Electrochemical Control of Bacterial Persister Cells
… percentage of phenotypic variants, known as persister cells, which are metabolically inactive and extremely tolerant to antibiotics. When the antibiotic treatment is stopped, surviving persister cells can regenerate the bacterial population with a similar percentage of persister cells. Thus, …
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CONTROLLING BIOFILM AND PERSISTER CELLS BY TARGETING CELL MEMBRANES
… of intrinsic mechanisms of drug resistance is persister formation, by which bacterial cells enter a metabolically inactive stage and become highly tolerant to essentially all antibiotics, even at the concentrations that are hundreds of times higher than the lethal dose required to kill normal …
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Controlling Bacterial Persister Cells and Biofilms by Synthetic Brominated Furanones
… biofilms, and by entering dormancy and forming persister cells. Both mechanisms allow bacteria to tolerate antibiotics at concentrations hundreds to thousands of times higher than the lethal dose for regular planktonic cells of the same genotype. Persister formation increases in biofilms; thus, …
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Controlling Pseudomonas aeruginosa Persister Cells by Human Granulocyte Macrophage Colony-Stimulating Factor
… for the first time that GM-CSF can sensitize the persister cells of P. aeruginosa PAO1 to multiple antibiotics including ciprofloxacin, tobramycin, tetracycline, and gentamicin. The mucoid variant, P. aeruginosa PDO300 was also sensitized by GM-CSF to tobramycin in the presence of alginate lyase. …
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The Emergence of Diverse Drug-Resistance Mechanisms from Drug Tolerant Cancer Persister Cells
… drug pressure by entering a slow-growing "persister" state. This drug-tolerant state has been hypothesized to be part of an initial strategy towards eventual acquisition of bona fide drug-resistance mechanisms. However, the diversity and clinical relevance of drug-resistance mechanisms that …
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Mitochondrial Stress Signals Induce a Drug Tolerant Persister Phenotype in Triple Negative Breast Cancer Cell Models
… pathway involving formation of drug tolerant persister (DTP) cancer cells has been identified. DTP cells utilize novel non-genetic survival mechanisms driven by transcriptional and epigenetic changes without alteration of the cellular genetic makeup. DTP cells have also been shown to modulate …
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Transient Metabolic Alterations Induced by Chemotherapeutics in Cancer Persisters
… has revealed the existence of slow-cycling persister cells that survive drug treatments and give rise to multi-drug tolerant mutants in cancer. The mechanisms associated with persister phenotypes are highly diverse and complex, and many aspects of persister cell physiology remain to be …
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Chimera Ligand for Pili and Lectin A Protein Controls Antibiotic-Promoted Biofilm Formation, Swarming Motility, Tolerance and Persister Formation by Pseudomonas aeruginosa
… eliminate drug-tolerant bacteria and to reduce persisters, in combination with antibiotics was demonstrated. </p> <p>The binding property of chimera ligands was demonstrated by competitive fluorescence polarization assay (LecA) and by adding a functional group to a ligand that can covalently …
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Academic Persistence and Attrition Among Freshman Traditional and Non-Traditional Students at a Public Midwestern Commuter University
… of the five scales did not differentiate between persisters and non-persisters; however, interaction effects were found between type of student and level of persistence on two of the five scales, and only one scale differentiated between persister/nonpersister students by …
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Targeting infectious species by Structure-guided Fragment-based Drug Discovery and in silico approach
… non-essential activities or creating dormant ‘persister’ states. The mechanisms of triggering persister phenotypes seem rather unclear but Toxin-antitoxin (TA) complexes have been reported to play a significant role in triggering persister phenotype. In this thesis, novel and validated targets …
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Cell-Mediated Cytotoxicity of Jensen Tumor in Sprague-Dawley Rats
… (PHA, a T cell mitogen) was decreased in persister rats; while Poke Weed mitogen (PWM; a B cell mitogen) stimulation was increased in persister rats. Treatment of "immune" lymphocytes with a) supernatants from tumor cell cultures, b) irradiated tumor cells or c) sonicated tumor cells did …
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Réponse du complexe de coléoptères à différents régimes d'éclaircie commerciale au sein de plantations d'épinettes blanches
… sur la communauté de coléoptères vont persister." -- Sommaire.
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Population dynamics of bacterial persistence
… of population in a drug tolerant state, the persister state. Specifically, persister cells grow more slowly than normal cells under growth conditions, but survive longer under stress conditions such as the antibiotic administrations. Bacterial persistence is identified experimentally by …
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Stopping Out and Persisting: Experiences of Latino Undergraduate Students
… stopout group when compared to students in the persister group.
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Computational Systems Biology Analysis of Cell Reprogramming and Activation Dynamics
… E.coli between normally-growing cells and persister cells (growth-arrested phenotype), and how this process can contribute to drug resistance. We built up a complex computational model capturing the molecular mechanism on both single cell level and population level. The paper also proposed …
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The microbiology of diabetic foot infections: a Ghanaian perspective
… resistance genes and/or the presence of persister cells that are unresponsive to antimicrobial agents. The work presented here studied the role of 2 multidrug resistant DFU isolates, Klebsiella pneumoniae and Proteus mirabilis in maintaining the chronicity of diabetic foot ulcers. Using 3 …
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Comorbidité entre les problèmes de comportement et les problèmes d’anxiété chez les enfants d’âge primaire : évolution sur une année
… peuvent vivre de grandes difficultés qui peuvent persister jusqu’à l’âge adulte (Woodward et Fergusson, 2001). D’autre part, les enfants vivant avec des problèmes de comportement rencontrent eux aussi de grandes difficultés et bénéficieraient de suivis pour minimiser l’évolution vers des troubles …
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A Study of First-Time Full-Time Freshmen's Attributes and Their Associations with Fall-to-Fall Retention Rates at a Two-Year Public Community College.
… was used to categorize individuals into persister and non-persister classifications for the subsequent fall. The data for this longitudinal study were housed in Northeast State's student records database, Student Information System.</p><p>A preliminary analysis of the data was conducted …
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Stepping Stones to Self-Change: A Narrative, Psychosocial Mapping of the Desistance Journey
… has been limited by a tendency to focus on persister/desister dichotomies. In overlooking the nuanced change that occurs between each endpoint, research has yet to address critical questions, such as how agentic and structural factors interact to produce change. This has particularly limited …
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Smart microscopy methods for quantitative microbiology
… enabling the observation of extremely rare persister events under various conditions. This scale revealed that under ampicillin treatment, persisters are predominantly slow-growing rather than dormant. We also find that a significant number of viable but non-culturable cells show signs of …
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