Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"persistent sodium"”.
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Modulation of Axonal Transmission by Metabolic Stress
… as it did not mimic exposure to divalent cation. Persistent and resurgent sodium channels could also be responsible for the ADP and are known to be blocked by divalent cations. Computer modeling confirmed that a persistent sodium channel could shorten AHP and improve CV. Therefore, we believe …
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Development and Mechanism of Oxygen Sensitivity in Caudal Hypothalamic Neurons
… that this inward current response was due to sodium and not calcium current. This sodium current was then studied in greater detail in acutely dissociated caudal hypothalamic neurons from mature rats. Whole-cell patch clamp recordings determined that both the fast-inactivating and persistent …
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VOLTAGE GATED SODIUM CHANNEL AND NEURONAL DIFFERENTIATION. IMPLICATIONS IN AMYOTROPHIC LATERAL SCLEROSIS PATHOGENESIS
Voltage gated sodium channels (VGSCs) are multimeric protein complexes formed by one alpha subunit, responsible of pore formation and of the regulation of the state of the channel, and by one or two accessory beta subunits that have an important role in the regulation of alpha subunit localization …
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Spontaneous activity in the mouse visual cortical slice: biophysical characterization and pathophysiology
… active by altering the activity of the persistent sodium current. In Chapter 3, I detail my journey investigating the pathophysiology underlying the hyperactivity phenotype in Fmr1-KO mice. While my early investigations indicated that depolarized intratelencephalic layer 5 pyramidal …